P45579 (YBDH_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized oxidoreductase YbdH
EC=1.1.-.-

Gene names

Name:	ybdH
Ordered Locus Names:	b0599, JW0592

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the iron-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on CH-OH group of donors Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Uncharacterized oxidoreductase YbdH		PRO_0000087831
Sites
	Metal binding	173	1	Zinc; catalytic By similarity
	Metal binding	257	1	Zinc; catalytic By similarity
	Metal binding	274	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45579 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: C28BBB4F8F247AE2	FASTA	362	39,092
	10 20 30 40 50 60 MPHNPIRVVV GPANYFSHPG SFNHLHDFFT DEQLSRAVWI YGKRAIAAAQ TKLPPAFGLP 70 80 90 100 110 120 GAKHILFRGH CSESDVQQLA AESGDDRSVV IGVGGGALLD TAKALARRLG LPFVAVPTIA 130 140 150 160 170 180 ATCAAWTPLS VWYNDAGQAL HYEIFDDANF MVLVEPEIIL NAPQQYLLAG IGDTLAKWYE 190 200 210 220 230 240 AVVLAPQPET LPLTVRLGIN NAQAIRDVLL NSSEQALSDQ QNQQLTQSFC DVVDAIIAGG 250 260 270 280 290 300 GMVGGLGDRF TRVAAAHAVH NGLTVLPQTE KFLHGTKVAY GILVQSALLG QDDVLAQLTG 310 320 330 340 350 360 AYQRFHLPTT LAELEVDINN QAEIDKVIAH TLRPVESIHY LPVTLTPDTL RAAFKKVESF KA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Molecular and functional characterization of a carbon starvation gene of Escherichia coli." Schultz J.E., Matin A. J. Mol. Biol. 218:129-140(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 282-362. Strain: K12.
[6]	"Detection of new genes in a bacterial genome using Markov models for three gene classes." Borodovsky M., McIninch J., Koonin E.V., Rudd K.E., Medigue C., Danchin A. Nucleic Acids Res. 23:3554-3562(1995) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U82598 Genomic DNA. Translation: AAB40800.1. U00096 Genomic DNA. Translation: AAC73700.1. AP009048 Genomic DNA. Translation: BAA35229.1. X52904 Genomic DNA. No translation available.
PIR	E64793.
RefSeq	NP_415132.1. NC_000913.2. YP_488889.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P45579.
SMR	P45579. Positions 7-360.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-11347N.
IntAct	P45579. 5 interactions.
MINT	MINT-1302765.
STRING	511145.b0599.
Proteomic databases
PRIDE	P45579.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC73700; AAC73700; b0599. BAA35229; BAA35229; BAA35229.
GeneID	12930898. 945212.
KEGG	ecj:Y75_p0589. eco:b0599.
PATRIC	32116376. VBIEscCol129921_0628.
Organism-specific databases
EchoBASE	EB2555.
EcoGene	EG12692. ybdH.
Phylogenomic databases
eggNOG	COG0371.
HOGENOM	HOG000031783.
KO	K08317.
OMA	GLGGAQC.
ProtClustDB	PRK10586.
Enzyme and pathway databases
BioCyc	EcoCyc:EG12692-MONOMER. ECOL316407:JW0592-MONOMER.
Gene expression databases
Genevestigator	P45579.
Family and domain databases
InterPro	IPR001670. ADH_Fe. IPR018211. ADH_Fe_CS. IPR016205. Glycerol_DH. [Graphical view]
Pfam	PF00465. Fe-ADH. 1 hit. [Graphical view]
PIRSF	PIRSF000112. Glycerol_dehydrogenase. 1 hit.
PROSITE	PS00913. ADH_IRON_1. 1 hit. PS00060. ADH_IRON_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YBDH_ECOLI

Accession

Primary (citable) accession number: P45579
Secondary accession number(s): P77632

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program