P45577 (PROQ_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ProP effector

Gene names

Name:	proQ
Synonyms:	yebJ, yobE, yoeC
Ordered Locus Names:	b1831, JW5300

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Not exactly known; may be a structural element that influences the osmotic activation of ProP at a post-translational level. HAMAP-Rule MF_00749
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00749.
Sequence similarities	Belongs to the ProQ family.
Sequence caution	The sequence BAA20566.1 differs from that shown. Reason: Erroneous initiation. The sequence described in Ref.5 differs from that shown. Reason: Frameshift at position 151.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of transport Inferred from genetic interaction Ref.1. Source: EcoCyc posttranscriptional regulation of gene expression Inferred from direct assay PubMed 21381725. Source: EcoCyc response to DNA damage stimulus Inferred from mutant phenotype PubMed 23308060. Source: EcoCyc
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA strand annealing activity Inferred from direct assay PubMed 21381725. Source: EcoCyc RNA strand-exchange activity Inferred from direct assay PubMed 21381725. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	ProP effector HAMAP-Rule MF_00749		PRO_0000214614

Sequences

	Sequence		Length	Mass (Da)
	P45577 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 042BEAA345A3C739	FASTA	232	25,893
	10 20 30 40 50 60 MENQPKLNSS KEVIAFLAER FPHCFSAEGE ARPLKIGIFQ DLVDRVAGEM NLSKTQLRSA 70 80 90 100 110 120 LRLYTSSWRY LYGVKPGATR VDLDGNPCGE LDEQHVEHAR KQLEEAKARV QAQRAEQQAK 130 140 150 160 170 180 KREAAATAGE KEDAPRRERK PRPTTPRRKE GAERKPRAQK PVEKAPKTVK APREEQHTPV 190 200 210 220 230 SDISALTVGQ ALKVKAGQNA MDATVLEITK DGVRVQLNSG MSLIVRAEHL VF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Protein ProQ influences osmotic activation of compatible solute transporter ProP in Escherichia coli K-12." Kunte H.J., Crane R.A., Culham D.E., Richmond D., Wood J.M. J. Bacteriol. 181:1537-1543(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL CHARACTERIZATION. Strain: K12.
[2]	"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. , Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T. DNA Res. 3:379-392(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Cloning, mapping, and characterization of the Escherichia coli prc gene, which is involved in C-terminal processing of penicillin-binding protein 3." Hara H., Yamamoto Y., Higashitani A., Suzuki H., Nishimura Y. J. Bacteriol. 173:4799-4813(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-232. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]	"Detection of new genes in a bacterial genome using Markov models for three gene classes." Borodovsky M., McIninch J., Koonin E.V., Rudd K.E., Medigue C., Danchin A. Nucleic Acids Res. 23:3554-3562(1995) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L48409 Genomic DNA. Translation: AAD41527.1. U00096 Genomic DNA. Translation: AAC74901.2. AP009048 Genomic DNA. Translation: BAA15639.2. D00674 Genomic DNA. Translation: BAA20566.1. Different initiation.
PIR	G64944.
RefSeq	YP_026161.1. NC_000913.2. YP_490093.1. NC_007779.1.
3D structure databases
DisProt	DP00377.
ProteinModelPortal	P45577.
SMR	P45577. Positions 7-117.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-10572N.
STRING	511145.b1831.
Proteomic databases
PaxDb	P45577.
PRIDE	P45577.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC74901; AAC74901; b1831. BAA15639; BAA15639; BAA15639.
GeneID	12931702. 948950.
KEGG	ecj:Y75_p1807. eco:b1831.
PATRIC	32118983. VBIEscCol129921_1909.
Organism-specific databases
EchoBASE	EB2707.
EcoGene	EG12866. proQ.
Phylogenomic databases
eggNOG	COG3109.
HOGENOM	HOG000290843.
KO	K03607.
OMA	GELEQQH.
ProtClustDB	PRK04950.
Enzyme and pathway databases
BioCyc	EcoCyc:EG12866-MONOMER. ECOL316407:JW5300-MONOMER.
Gene expression databases
Genevestigator	P45577.
Family and domain databases
Gene3D	1.10.1710.10. 1 hit.
HAMAP	MF_00749. ProQ.
InterPro	IPR016103. Fertility_inhib_FinO/ProQ. IPR023529. Transptr_ProQ. [Graphical view]
Pfam	PF04352. ProQ. 1 hit. [Graphical view]
SMART	SM00945. ProQ. 1 hit. [Graphical view]
SUPFAM	SSF48657. FINO. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PROQ_ECOLI

Accession

Primary (citable) accession number: P45577
Secondary accession number(s): P56606

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	July 15, 1999
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program