Reviewed, UniProtKB/Swiss-Prot P45575 (DSVB_DESVH)

Names and origin

Protein names

Recommended name:
    Sulfite reductase, dissimilatory-type subunit beta
    EC=1.8.99.3
Alternative name(s):
    Desulfoviridin subunit beta
    Hydrogensulfite reductase subunit beta

Gene names

Name:	dsvB
Ordered Locus Names:	DVU_0403

Organism

Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Complete proteome] [HAMAP]

Taxonomic identifier

882 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the reduction of sulfite to sulfide. This is the terminal oxidation reaction in sulfate respiration, a process catalyzed by the sulfate-reducing bacteria.
Catalytic activity	(O(3)S.S.SO(3))(2-) + acceptor + 2 H(2)O + OH(-) = 3 HSO(3)(-) + reduced acceptor.
Cofactor	Binds 1 4Fe-4S cluster per subunit. Binds 2 sirohemes per subunit.
Subunit structure	Heterohexamer of two alpha, two beta and two gamma subunits.
Sequence similarities	Contains 1 4Fe-4S ferredoxin-type domain.

Ontologies

Keywords
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro hydrogensulfite reductase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 381	380	Sulfite reductase, dissimilatory-type subunit beta		PRO_0000080032
Regions
	Domain	249 – 276	28	4Fe-4S ferredoxin-type
Sites
	Metal binding	231	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	258	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	261	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	264	1	Iron-sulfur (4Fe-4S) Potential

Sequences

	Sequence		Length	Mass (Da)
	P45575-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 678A04F716050D63	FASTA	381	42,519
	10 20 30 40 50 60 MAFISSGYNP EKPMANRITD IGPRKFDEFF PPVIAKNFGS WLYHEILEPG VLMHVAESGD 70 80 90 100 110 120 KVYTVRVGAA RLMSITHIRE MCDIADKYCG GHLRFTTRNN VEFMVADEAS LKALKEDLAS 130 140 150 160 170 180 RKFDGGSLKF PIGGTGAGVS NIVHTQGWVH CHTPATDASG PVKAIMDEVF EDFQSMRLPA 190 200 210 220 230 240 PVRISLACCI NMCGAVHCSD IGVVGIHRKP PMIDHEWTDQ LCEIPLAVAS CPTAAVRPTK 250 260 270 280 290 300 LEIGDKKVNT IAIKNERCMY CGNCYTMCPA LPISDGEGDG VVIMVGGKVS NRISMPKFSK 310 320 330 340 350 360 VVVAYIPNEP PRWPSLTKTI KHIIEVYSAN AYKYERLGEW AERIGWERFF SLTGLEFSHH 370 380 LIDDFRDPAY YTWRQSTQFK F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Conservation of the genes for dissimilatory sulfite reductase from Desulfovibrio vulgaris and Archaeoglobus fulgidus allows their detection by PCR." Karkhoff-Schweizer R.R., Huber D.P.W., Voordouw G. Appl. Environ. Microbiol. 61:290-296(1995) [PubMed: 7887608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough." Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T., Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M., Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Fouts D.E. , Haft D.H., Selengut J., Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D., Voordouw G., Fraser C.M. Nat. Biotechnol. 22:554-559(2004) [PubMed: 15077118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The third subunit of desulfoviridin-type dissimilatory sulfite reductases." Pierik A.J., Duyvis M.G., van Helvoort J.M.L.M., Wolbert R.B.G., Hagen W.R. Eur. J. Biochem. 205:111-115(1992) [PubMed: 1555572] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-16.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U16723 Genomic DNA. Translation: AAA70108.1. AE017285 Genomic DNA. Translation: AAS94886.1.
PIR	S21238.
RefSeq	YP_009627.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2796153.
GenomeReviews	Gene locus DVU_0403 in contig AE017285_GR.
KEGG	dvu:DVU0403.
TIGR	DVU_0403.
Phylogenomic databases
HOGENOM	P45575.
Enzyme and pathway databases
BioCyc	DVUL882:DVU_0403-MON. MetaCyc:MON-12512.
Family and domain databases
InterPro	IPR001450. 4Fe4S_Fe_S_bd. IPR011808. DsrB. IPR006067. Nir_Sir_4Fe4S. IPR005117. NiRdtase/SiRdtase_haem-b_fer. [Graphical view]
Pfam	PF00037. Fer4. 1 hit. PF01077. NIR_SIR. 1 hit. PF03460. NIR_SIR_ferr. 1 hit. [Graphical view]
TIGRFAMs	TIGR02066. dsrB. 1 hit.
PROSITE	PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSVB_DESVH

Accession

Primary (citable) accession number: P45575

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 59 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)