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Protein

Lipopolysaccharide core heptose(II)-phosphate phosphatase

Gene

ais

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core.By similarity

Pathwayi: lipopolysaccharide metabolism

This protein is involved in the pathway lipopolysaccharide metabolism, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide metabolism and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciEcoCyc:G7165-MONOMER
UniPathwayiUPA00451

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide core heptose(II)-phosphate phosphatase (EC:3.1.3.-)
Alternative name(s):
Polymyxin resistance protein PmrG
Gene namesi
Name:ais
Synonyms:pmrG
Ordered Locus Names:b2252, JW2246
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13155 ais

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000006451526 – 200Lipopolysaccharide core heptose(II)-phosphate phosphataseAdd BLAST175

Proteomic databases

EPDiP45565
PaxDbiP45565
PRIDEiP45565

Expressioni

Inductioni

Induced by BasR (By similarity). Expression is significantly induced in the presence of zinc.By similarity1 Publication

Interactioni

Protein-protein interaction databases

BioGridi426048711 interactors.
IntActiP45565 2 interactors.
STRINGi316385.ECDH10B_2412

Structurei

3D structure databases

ProteinModelPortaliP45565
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108WMR Bacteria
ENOG4111KYS LUCA
HOGENOMiHOG000122412
OMAiNFTVIVW

Family and domain databases

Gene3Di3.40.50.12401 hit
HAMAPiMF_01868 Ais, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR011310 LipoPS_heptP_Pase
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
PIRSFiPIRSF011416 Ais-TraG-AfrS, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAFCRSSLK SKKYIIILLA LAAIAGLGTH AAWSSNGLPR IDNKTLARLA
60 70 80 90 100
QQHPVVVLFR HAERCDRSTN QCLSDKTGIT VKGTQDAREL GNAFSADIPD
110 120 130 140 150
FDLYSSNTVR TIQSATWFSA GKKLTVDKRL LQCGNEIYSA IKDLQSKAPD
160 170 180 190 200
KNIVIFTHNH CLTYIAKDKR DATFKPDYLD GLVMHVEKGK VYLDGEFVNH
Length:200
Mass (Da):22,257
Last modified:November 1, 1997 - v2
Checksum:iA210382654AC6B35
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200H → Y in CAA58754 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83874 Genomic DNA Translation: CAA58754.1
U00096 Genomic DNA Translation: AAC75312.1
AP009048 Genomic DNA Translation: BAA16075.1
PIRiB64996
RefSeqiNP_416755.1, NC_000913.3
WP_000879112.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75312; AAC75312; b2252
BAA16075; BAA16075; BAA16075
GeneIDi944945
KEGGiecj:JW2246
eco:b2252
PATRICifig|511145.12.peg.2344

Similar proteinsi

Entry informationi

Entry nameiAIS_ECOLI
AccessioniPrimary (citable) accession number: P45565
Secondary accession number(s): P77314
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome