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Protein

Amelogenin

Gene

AMEL

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.

GO - Molecular functioni

  • calcium ion binding Source: CAFA
  • identical protein binding Source: CAFA
  • structural constituent of tooth enamel Source: GO_Central

GO - Biological processi

  • enamel mineralization Source: CAFA
  • protein homooligomerization Source: CAFA

Keywordsi

Biological processBiomineralization

Enzyme and pathway databases

ReactomeiR-SSC-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-SSC-8957275. Post-translational protein phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Amelogenin
Alternative name(s):
Amelogenin 173A/173B
Leucine-rich amelogenin peptide
Short name:
LRAP
Gene namesi
Name:AMEL
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome X

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000000120317 – 189AmelogeninAdd BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32Phosphoserine1 Publication1

Post-translational modificationi

A number of other isoforms are produced by carboxy-terminal processing.

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP45561.

Miscellaneous databases

PMAP-CutDBiP45561.

Expressioni

Gene expression databases

BgeeiENSSSCG00000012113.
ExpressionAtlasiP45561. differential.
GenevisibleiP45561. SS.

Interactioni

GO - Molecular functioni

  • identical protein binding Source: CAFA

Structurei

3D structure databases

DisProtiDP00693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amelogenin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00390000009151.
HOGENOMiHOG000231643.
HOVERGENiHBG016835.
InParanoidiP45561.

Family and domain databases

InterProiView protein in InterPro
IPR004116. Amelogenin.
PfamiView protein in Pfam
PF02948. Amelogenin. 1 hit.
PRINTSiPR01757. AMELOGENIN.
SMARTiView protein in SMART
SM00818. Amelogenin. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P45561-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTWILFACL LGAAFSMPLP PHPGHPGYIN FSYEVLTPLK WYQNMIRHPY
60 70 80 90 100
TSYGYEPMGG WLHHQIIPVV SQQTPQSHAL QPHHHIPMVP AQQPGIPQQP
110 120 130 140 150
MMPLPGQHSM TPTQHHQPNL PLPAQQPFQP QPVQPQPHQP LQPQSPMHPI
160 170 180
QPLLPQPPLP PMFSMQSLLP DLPLEAWPAT DKTKREEVD
Length:189
Mass (Da):21,387
Last modified:October 1, 1996 - v2
Checksum:i6392212E0A31D00C
GO
Isoform 2 (identifier: P45561-2) [UniParc]FASTAAdd to basket
Also known as: LRAP

The sequence of this isoform differs from the canonical sequence as follows:
     34-45: Missing.

Show »
Length:177
Mass (Da):19,883
Checksum:i9902EC3D6627E6EC
GO
Isoform 3 (identifier: P45561-3) [UniParc]FASTAAdd to basket
Also known as: 173B

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: L → F
     14-16: AFS → SLA

Show »
Length:189
Mass (Da):21,387
Checksum:iBE633A7C727D1B07
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0002336L → F in isoform 3. Curated1
Alternative sequenceiVSP_00023414 – 16AFS → SLA in isoform 3. Curated3
Alternative sequenceiVSP_00023234 – 45Missing in isoform 2. CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43405 mRNA. Translation: AAB41110.1.
U43406 mRNA. Translation: AAB41111.1.
RefSeqiNP_998965.1. NM_213800.1. [P45561-3]
NP_999071.1. NM_213906.1. [P45561-1]
UniGeneiSsc.179.

Genome annotation databases

EnsembliENSSSCT00000013248; ENSSSCP00000012892; ENSSSCG00000012113. [P45561-1]
GeneIDi396714.
396940.
KEGGissc:396714.
ssc:396940.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAMEL_PIG
AccessioniPrimary (citable) accession number: P45561
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families