Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable fructoselysine utilization operon transcriptional repressor

Gene

frlR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine.1 Publication

Pathwayi: fructoselysine degradation

This protein regulates the pathway fructoselysine degradation, which is part of Carbohydrate metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway fructoselysine degradation and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 57H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7727-MONOMER.
UniPathwayiUPA00784.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fructoselysine utilization operon transcriptional repressor1 Publication
Alternative name(s):
HTH-type transcriptional regulator FrlRCurated
Gene namesi
Name:frlR1 Publication
Synonyms:yhfR
Ordered Locus Names:b3375, JW5698
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12913. frlR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506421 – 243Probable fructoselysine utilization operon transcriptional repressorAdd BLAST243

Proteomic databases

PaxDbiP45544.
PRIDEiP45544.

Expressioni

Inductioni

Induced by fructoselysine. Makes part of the frl operon with FrlA, FrlB, FrlC and FrlD.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259581. 11 interactors.
DIPiDIP-12327N.
IntActiP45544. 5 interactors.
STRINGi316385.ECDH10B_3550.

Structurei

3D structure databases

ProteinModelPortaliP45544.
SMRiP45544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 78HTH gntR-typePROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiENOG4105FDP. Bacteria.
COG2188. LUCA.
HOGENOMiHOG000228717.
InParanoidiP45544.
KOiK10711.
PhylomeDBiP45544.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.1410.10. 1 hit.
InterProiView protein in InterPro
IPR028978. Chorismate_lyase_/UTRA_dom.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011663. UTRA.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00392. GntR. 1 hit.
PF07702. UTRA. 1 hit.
PRINTSiPR00035. HTHGNTR.
SMARTiView protein in SMART
SM00345. HTH_GNTR. 1 hit.
SM00866. UTRA. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF64288. SSF64288. 1 hit.
PROSITEiView protein in PROSITE
PS50949. HTH_GNTR. 1 hit.

Sequencei

Sequence statusi: Complete.

P45544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATDRYSHQ LLYATVRQRL LDDIAQGVYQ AGQQIPTENE LCTQYNVSRI
60 70 80 90 100
TIRKAISDLV ADGVLIRWQG KGTFVQSQKV ENALLTVSGF TDFGVSQGKA
110 120 130 140 150
TKEKVIEQER VSAAPFCEKL NIPGNSEVFH LCRVMYLDKE PLFIDSSWIP
160 170 180 190 200
LSRYPDFDEI YVEGSSTYQL FQERFDTRVV SDKKTIDIFA ATRPQAKWLK
210 220 230 240
CELGEPLFRI SKIAFDQNDK PVHVSELFCR ANRITLTIDN KRH
Length:243
Mass (Da):27,821
Last modified:December 15, 1998 - v2
Checksum:i973FEE8232B9B0F6
GO

Sequence cautioni

The sequence AAA58172 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58172.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76400.2.
AP009048 Genomic DNA. Translation: BAE77916.1.
PIRiB65132.
RefSeqiNP_417834.6. NC_000913.3.
WP_001276847.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76400; AAC76400; b3375.
BAE77916; BAE77916; BAE77916.
GeneIDi947885.
KEGGiecj:JW5698.
eco:b3375.
PATRICifig|1411691.4.peg.3355.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFRLR_ECOLI
AccessioniPrimary (citable) accession number: P45544
Secondary accession number(s): Q2M740
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 15, 1998
Last modified: July 5, 2017
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways