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Protein

Probable fructoselysine utilization operon transcriptional repressor

Gene

frlR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine.1 Publication

Pathwayi: fructoselysine degradation

This protein regulates the pathway fructoselysine degradation, which is part of Carbohydrate metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway fructoselysine degradation and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 57H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7727-MONOMER
UniPathwayiUPA00784

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fructoselysine utilization operon transcriptional repressor1 Publication
Alternative name(s):
HTH-type transcriptional regulator FrlRCurated
Gene namesi
Name:frlR1 Publication
Synonyms:yhfR
Ordered Locus Names:b3375, JW5698
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12913 frlR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506421 – 243Probable fructoselysine utilization operon transcriptional repressorAdd BLAST243

Proteomic databases

PaxDbiP45544
PRIDEiP45544

Expressioni

Inductioni

Induced by fructoselysine. Makes part of the frl operon with FrlA, FrlB, FrlC and FrlD.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
topBP142942EBI-562481,EBI-552080

Protein-protein interaction databases

BioGridi4259581, 14 interactors
DIPiDIP-12327N
IntActiP45544, 5 interactors
STRINGi316385.ECDH10B_3550

Structurei

3D structure databases

ProteinModelPortaliP45544
SMRiP45544
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 78HTH gntR-typePROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiENOG4105FDP Bacteria
COG2188 LUCA
HOGENOMiHOG000228717
InParanoidiP45544
KOiK10711
OMAiNRHTVRS
PhylomeDBiP45544

Family and domain databases

CDDicd07377 WHTH_GntR, 1 hit
Gene3Di1.10.10.10, 1 hit
3.40.1410.10, 1 hit
InterProiView protein in InterPro
IPR028978 Chorismate_lyase_/UTRA_dom_sf
IPR000524 Tscrpt_reg_HTH_GntR
IPR011663 UTRA
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00392 GntR, 1 hit
PF07702 UTRA, 1 hit
PRINTSiPR00035 HTHGNTR
SMARTiView protein in SMART
SM00345 HTH_GNTR, 1 hit
SM00866 UTRA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF64288 SSF64288, 1 hit
PROSITEiView protein in PROSITE
PS50949 HTH_GNTR, 1 hit

Sequencei

Sequence statusi: Complete.

P45544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATDRYSHQ LLYATVRQRL LDDIAQGVYQ AGQQIPTENE LCTQYNVSRI
60 70 80 90 100
TIRKAISDLV ADGVLIRWQG KGTFVQSQKV ENALLTVSGF TDFGVSQGKA
110 120 130 140 150
TKEKVIEQER VSAAPFCEKL NIPGNSEVFH LCRVMYLDKE PLFIDSSWIP
160 170 180 190 200
LSRYPDFDEI YVEGSSTYQL FQERFDTRVV SDKKTIDIFA ATRPQAKWLK
210 220 230 240
CELGEPLFRI SKIAFDQNDK PVHVSELFCR ANRITLTIDN KRH
Length:243
Mass (Da):27,821
Last modified:December 15, 1998 - v2
Checksum:i973FEE8232B9B0F6
GO

Sequence cautioni

The sequence AAA58172 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58172.1 Different initiation.
U00096 Genomic DNA Translation: AAC76400.2
AP009048 Genomic DNA Translation: BAE77916.1
PIRiB65132
RefSeqiNP_417834.6, NC_000913.3
WP_001276847.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76400; AAC76400; b3375
BAE77916; BAE77916; BAE77916
GeneIDi947885
KEGGiecj:JW5698
eco:b3375
PATRICifig|1411691.4.peg.3355

Similar proteinsi

Entry informationi

Entry nameiFRLR_ECOLI
AccessioniPrimary (citable) accession number: P45544
Secondary accession number(s): Q2M740
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 15, 1998
Last modified: March 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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