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Protein

Putative fructoselysine transporter FrlA

Gene

frlA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in fructoselysine transport.1 Publication

Pathwayi: fructoselysine degradation

This protein is involved in the pathway fructoselysine degradation, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway fructoselysine degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

  • fructoselysine metabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YHFM-MONOMER.
ECOL316407:JW3333-MONOMER.
MetaCyc:YHFM-MONOMER.
UniPathwayiUPA00784.

Protein family/group databases

TCDBi2.A.3.8.17. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fructoselysine transporter FrlA
Gene namesi
Name:frlA
Synonyms:yhfM
Ordered Locus Names:b3370, JW3333
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12908. frlA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Transmembranei389 – 410HelicalSequence analysisAdd BLAST22
Transmembranei417 – 435HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542471 – 445Putative fructoselysine transporter FrlAAdd BLAST445

Proteomic databases

PaxDbiP45539.
PRIDEiP45539.

Interactioni

Protein-protein interaction databases

BioGridi4262479. 5 interactors.
DIPiDIP-12322N.
IntActiP45539. 1 interactor.
STRINGi511145.b3370.

Structurei

3D structure databases

ProteinModelPortaliP45539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QHQ. Bacteria.
COG0531. LUCA.
HOGENOMiHOG000005029.
InParanoidiP45539.
KOiK19540.
OMAiWPWAWAQ.
PhylomeDBiP45539.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

P45539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSQELQRKL GFWAVLAIAV GTTVGSGIFV SVGEVAKAAG TPWLTVLAFV
60 70 80 90 100
IGGLIVIPQM CVYAELSTAY PENGADYVYL KNAGSRPLAF LSGWASFWAN
110 120 130 140 150
DAPSLSIMAL AIVSNLGFLT PIDPLLGKFI AAGLIIAFML LHLRSVEGGA
160 170 180 190 200
AFQTLITIAK IIPFTIVIGL GIFWFKAENF AAPTTTAIGA TGSFMALLAG
210 220 230 240 250
ISATSWSYTG MASICYMTGE IKNPGKTMPR ALIGSCLLVL VLYTLLALVI
260 270 280 290 300
SGLMPFDKLA NSETPISDAL TWIPALGSTA GIFVAITAMI VILGSLSSCV
310 320 330 340 350
MYQPRLEYAM AKDNLFFKCF GHVHPKYNTP DVSIILQGAL GIFFIFVSDL
360 370 380 390 400
TSLLGYFTLV MCFKNTLTFG SIIWCRKRDD YKPLWRTPAF GLMTTLAIAS
410 420 430 440
SLILVASTFV WAPIPGLICA VIVIATGLPA YAFWAKRSRQ LNALS
Length:445
Mass (Da):47,577
Last modified:July 15, 1998 - v2
Checksum:iB98DF5944A5E1FEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58167.1. Sequence problems.
U00096 Genomic DNA. Translation: AAC76395.2.
AP009048 Genomic DNA. Translation: BAE77920.1.
PIRiE65131.
RefSeqiNP_417829.2. NC_000913.3.
WP_000535505.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76395; AAC76395; b3370.
BAE77920; BAE77920; BAE77920.
GeneIDi947878.
KEGGiecj:JW3333.
eco:b3370.
PATRICi32122174. VBIEscCol129921_3464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58167.1. Sequence problems.
U00096 Genomic DNA. Translation: AAC76395.2.
AP009048 Genomic DNA. Translation: BAE77920.1.
PIRiE65131.
RefSeqiNP_417829.2. NC_000913.3.
WP_000535505.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP45539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262479. 5 interactors.
DIPiDIP-12322N.
IntActiP45539. 1 interactor.
STRINGi511145.b3370.

Protein family/group databases

TCDBi2.A.3.8.17. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbiP45539.
PRIDEiP45539.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76395; AAC76395; b3370.
BAE77920; BAE77920; BAE77920.
GeneIDi947878.
KEGGiecj:JW3333.
eco:b3370.
PATRICi32122174. VBIEscCol129921_3464.

Organism-specific databases

EchoBASEiEB2745.
EcoGeneiEG12908. frlA.

Phylogenomic databases

eggNOGiENOG4107QHQ. Bacteria.
COG0531. LUCA.
HOGENOMiHOG000005029.
InParanoidiP45539.
KOiK19540.
OMAiWPWAWAQ.
PhylomeDBiP45539.

Enzyme and pathway databases

UniPathwayiUPA00784.
BioCyciEcoCyc:YHFM-MONOMER.
ECOL316407:JW3333-MONOMER.
MetaCyc:YHFM-MONOMER.

Miscellaneous databases

PROiP45539.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFRLA_ECOLI
AccessioniPrimary (citable) accession number: P45539
Secondary accession number(s): P76686, Q2M736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.