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Protein

FKBP-type peptidyl-prolyl cis-trans isomerase FkpA

Gene

fkpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

  • chaperone-mediated protein folding Source: GO_Central
  • protein refolding Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciEcoCyc:G7716-MONOMER.
ECOL316407:JW3309-MONOMER.
BRENDAi5.2.1.8. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
FKBP-type peptidyl-prolyl cis-trans isomerase FkpA (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Rotamase
Gene namesi
Name:fkpA
Synonyms:yzzS
Ordered Locus Names:b3347, JW3309
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12900. fkpA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 270245FKBP-type peptidyl-prolyl cis-trans isomerase FkpAPRO_0000025536Add
BLAST

Proteomic databases

EPDiP45523.
PaxDbiP45523.
PRIDEiP45523.

2D gel databases

SWISS-2DPAGEP45523.

Interactioni

Protein-protein interaction databases

BioGridi4263165. 8 interactions.
DIPiDIP-9625N.
IntActiP45523. 17 interactions.
MINTiMINT-1228098.
STRINGi511145.b3347.

Structurei

Secondary structure

1
270
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi44 – 6825Combined sources
Turni69 – 713Combined sources
Helixi76 – 8712Combined sources
Helixi95 – 13743Combined sources
Beta strandi141 – 1433Combined sources
Beta strandi149 – 1546Combined sources
Beta strandi166 – 17510Combined sources
Beta strandi180 – 1834Combined sources
Helixi184 – 1874Combined sources
Beta strandi191 – 1944Combined sources
Helixi195 – 1973Combined sources
Helixi200 – 2056Combined sources
Helixi206 – 2083Combined sources
Beta strandi214 – 2196Combined sources
Helixi221 – 2233Combined sources
Turni224 – 2285Combined sources
Beta strandi239 – 24911Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q6HX-ray1.97A/B26-249[»]
1Q6IX-ray2.25A/B26-249[»]
1Q6UX-ray2.45A26-270[»]
ProteinModelPortaliP45523.
SMRiP45523. Positions 40-249.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45523.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 24986PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108V1T. Bacteria.
COG0545. LUCA.
HOGENOMiHOG000154888.
InParanoidiP45523.
KOiK03772.
OMAiTENASKG.
PhylomeDBiP45523.

Family and domain databases

Gene3Di1.10.287.460. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR000774. PPIase_FKBP_N.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
PF01346. FKBP_N. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLFKVTLL ATTMAVALHA PITFAAEAAK PATAADSKAA FKNDDQKSAY
60 70 80 90 100
ALGASLGRYM ENSLKEQEKL GIKLDKDQLI AGVQDAFADK SKLSDQEIEQ
110 120 130 140 150
TLQAFEARVK SSAQAKMEKD AADNEAKGKE YREKFAKEKG VKTSSTGLVY
160 170 180 190 200
QVVEAGKGEA PKDSDTVVVN YKGTLIDGKE FDNSYTRGEP LSFRLDGVIP
210 220 230 240 250
GWTEGLKNIK KGGKIKLVIP PELAYGKAGV PGIPPNSTLV FDVELLDVKP
260 270
APKADAKPEA DAKAADSAKK
Length:270
Mass (Da):28,882
Last modified:November 1, 1995 - v1
Checksum:iDBC73B8676BB63EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28082 Genomic DNA. Translation: AAC41459.1.
U18997 Genomic DNA. Translation: AAA58144.1.
U00096 Genomic DNA. Translation: AAC76372.1.
AP009048 Genomic DNA. Translation: BAE77944.1.
PIRiI65035.
RefSeqiNP_417806.1. NC_000913.3.
WP_000838250.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76372; AAC76372; b3347.
BAE77944; BAE77944; BAE77944.
GeneIDi947850.
KEGGiecj:JW3309.
eco:b3347.
PATRICi32122126. VBIEscCol129921_3440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28082 Genomic DNA. Translation: AAC41459.1.
U18997 Genomic DNA. Translation: AAA58144.1.
U00096 Genomic DNA. Translation: AAC76372.1.
AP009048 Genomic DNA. Translation: BAE77944.1.
PIRiI65035.
RefSeqiNP_417806.1. NC_000913.3.
WP_000838250.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q6HX-ray1.97A/B26-249[»]
1Q6IX-ray2.25A/B26-249[»]
1Q6UX-ray2.45A26-270[»]
ProteinModelPortaliP45523.
SMRiP45523. Positions 40-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263165. 8 interactions.
DIPiDIP-9625N.
IntActiP45523. 17 interactions.
MINTiMINT-1228098.
STRINGi511145.b3347.

2D gel databases

SWISS-2DPAGEP45523.

Proteomic databases

EPDiP45523.
PaxDbiP45523.
PRIDEiP45523.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76372; AAC76372; b3347.
BAE77944; BAE77944; BAE77944.
GeneIDi947850.
KEGGiecj:JW3309.
eco:b3347.
PATRICi32122126. VBIEscCol129921_3440.

Organism-specific databases

EchoBASEiEB2737.
EcoGeneiEG12900. fkpA.

Phylogenomic databases

eggNOGiENOG4108V1T. Bacteria.
COG0545. LUCA.
HOGENOMiHOG000154888.
InParanoidiP45523.
KOiK03772.
OMAiTENASKG.
PhylomeDBiP45523.

Enzyme and pathway databases

BioCyciEcoCyc:G7716-MONOMER.
ECOL316407:JW3309-MONOMER.
BRENDAi5.2.1.8. 2026.

Miscellaneous databases

EvolutionaryTraceiP45523.
PROiP45523.

Family and domain databases

Gene3Di1.10.287.460. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR000774. PPIase_FKBP_N.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
PF01346. FKBP_N. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBA_ECOLI
AccessioniPrimary (citable) accession number: P45523
Secondary accession number(s): P39175, Q2M712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.