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P45513

- DHAT_CITFR

UniProt

P45513 - DHAT_CITFR

Protein

1,3-propanediol dehydrogenase

Gene

dhaT

Organism
Citrobacter freundii
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate.

    Catalytic activityi

    Propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH.

    Cofactori

    Iron.

    GO - Molecular functioni

    1. 1,3-propanediol dehydrogenase activity Source: CACAO
    2. metal ion binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Iron, NAD

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-6429-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1,3-propanediol dehydrogenase (EC:1.1.1.202)
    Alternative name(s):
    1,3-propanediol oxidoreductase
    3-hydroxypropionaldehyde reductase
    Gene namesi
    Name:dhaT
    OrganismiCitrobacter freundii
    Taxonomic identifieri546 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacterCitrobacter freundii complex

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3873871,3-propanediol dehydrogenasePRO_0000087841Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer.

    Structurei

    3D structure databases

    ProteinModelPortaliP45513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR001670. ADH_Fe.
    IPR018211. ADH_Fe_CS.
    [Graphical view]
    PfamiPF00465. Fe-ADH. 1 hit.
    [Graphical view]
    PROSITEiPS00913. ADH_IRON_1. 1 hit.
    PS00060. ADH_IRON_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P45513-1 [UniParc]FASTAAdd to Basket

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    MSYRMFDYLV PNVNFFGPNA ISVVGERCKL LGGKKALLVT DKGLRAIKDG    50
    AVDKTLTHLR EAGIDVVVFD GVEPNPKDTN VRDGLEVFRK EHCDIIVTVG 100
    GGSPHDCGKG IGIAATHEGD LYSYAGIETL TNPLPPIVAV NTTAGTASEV 150
    TRHCVLTNTK TKVKFVIVSW RNLPSVSIND PLLMLGKPAP LTAATGMDAL 200
    THAVEAYISK DANPVTDAAA IQAIRLIARN LRQAVALGSN LKARENMAYA 250
    SLLAGMAFNN ANLGYVHAMA HQLGGLYDMP HGVANAVLLP HVARYNLIAN 300
    PEKFADIAEF MGENTDGLST MDAAELAIHA IARLSADIGI PQHLRDLGVK 350
    EADFPYMAEM ALKDGNAFSN PRKGNEKEIA EIFRQAF 387
    Length:387
    Mass (Da):41,482
    Last modified:November 1, 1995 - v1
    Checksum:i268F295DA83A8DCC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09771 Genomic DNA. Translation: AAB48848.1.
    PIRiA56275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09771 Genomic DNA. Translation: AAB48848.1 .
    PIRi A56275.

    3D structure databases

    ProteinModelPortali P45513.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-6429-MONOMER.

    Family and domain databases

    InterProi IPR001670. ADH_Fe.
    IPR018211. ADH_Fe_CS.
    [Graphical view ]
    Pfami PF00465. Fe-ADH. 1 hit.
    [Graphical view ]
    PROSITEi PS00913. ADH_IRON_1. 1 hit.
    PS00060. ADH_IRON_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification of 1,3-propanediol dehydrogenase from Citrobacter freundii and cloning, sequencing, and overexpression of the corresponding gene in Escherichia coli."
      Daniel R., Boenigk R., Gottschalk G.
      J. Bacteriol. 177:2151-2156(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 6750 / DSM 30040 / NCIB 8173 / M8BK.

    Entry informationi

    Entry nameiDHAT_CITFR
    AccessioniPrimary (citable) accession number: P45513
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3