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P45513

- DHAT_CITFR

UniProt

P45513 - DHAT_CITFR

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Protein
1,3-propanediol dehydrogenase
Gene
dhaT
Organism
Citrobacter freundii
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate.

Catalytic activityi

Propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH.

Cofactori

Iron.

GO - Molecular functioni

  1. 1,3-propanediol dehydrogenase activity Source: CACAO
  2. metal ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, NAD

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6429-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
1,3-propanediol dehydrogenase (EC:1.1.1.202)
Alternative name(s):
1,3-propanediol oxidoreductase
3-hydroxypropionaldehyde reductase
Gene namesi
Name:dhaT
OrganismiCitrobacter freundii
Taxonomic identifieri546 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacterCitrobacter freundii complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3873871,3-propanediol dehydrogenase
PRO_0000087841Add
BLAST

Interactioni

Subunit structurei

Homooctamer.

Structurei

3D structure databases

ProteinModelPortaliP45513.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45513-1 [UniParc]FASTAAdd to Basket

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MSYRMFDYLV PNVNFFGPNA ISVVGERCKL LGGKKALLVT DKGLRAIKDG    50
AVDKTLTHLR EAGIDVVVFD GVEPNPKDTN VRDGLEVFRK EHCDIIVTVG 100
GGSPHDCGKG IGIAATHEGD LYSYAGIETL TNPLPPIVAV NTTAGTASEV 150
TRHCVLTNTK TKVKFVIVSW RNLPSVSIND PLLMLGKPAP LTAATGMDAL 200
THAVEAYISK DANPVTDAAA IQAIRLIARN LRQAVALGSN LKARENMAYA 250
SLLAGMAFNN ANLGYVHAMA HQLGGLYDMP HGVANAVLLP HVARYNLIAN 300
PEKFADIAEF MGENTDGLST MDAAELAIHA IARLSADIGI PQHLRDLGVK 350
EADFPYMAEM ALKDGNAFSN PRKGNEKEIA EIFRQAF 387
Length:387
Mass (Da):41,482
Last modified:November 1, 1995 - v1
Checksum:i268F295DA83A8DCC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09771 Genomic DNA. Translation: AAB48848.1.
PIRiA56275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09771 Genomic DNA. Translation: AAB48848.1 .
PIRi A56275.

3D structure databases

ProteinModelPortali P45513.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-6429-MONOMER.

Family and domain databases

InterProi IPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view ]
Pfami PF00465. Fe-ADH. 1 hit.
[Graphical view ]
PROSITEi PS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification of 1,3-propanediol dehydrogenase from Citrobacter freundii and cloning, sequencing, and overexpression of the corresponding gene in Escherichia coli."
    Daniel R., Boenigk R., Gottschalk G.
    J. Bacteriol. 177:2151-2156(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 6750 / DSM 30040 / NCIB 8173 / M8BK.

Entry informationi

Entry nameiDHAT_CITFR
AccessioniPrimary (citable) accession number: P45513
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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