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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361GTPUniRule annotation
Binding sitei140 – 1401GTPUniRule annotation
Binding sitei184 – 1841GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 225GTPUniRule annotation
Nucleotide bindingi105 – 1073GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • barrier septum assembly Source: UniProtKB-KW
  • cell septum assembly Source: CACAO
  • FtsZ-dependent cytokinesis Source: UniProtKB-HAMAP
  • protein polymerization Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:SCO2082
ORF Names:SC4A10.15c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

  • barrier septum Source: CACAO
  • cell division site Source: UniProtKB-HAMAP
  • cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Cell division protein FtsZPRO_0000114388Add
BLAST

Proteomic databases

PRIDEiP45500.

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO2082.

Structurei

3D structure databases

ProteinModelPortaliP45500.
SMRiP45500. Positions 22-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
InParanoidiP45500.
KOiK03531.
OMAiNNAREEL.
OrthoDBiEOG6S7XZG.
PhylomeDBiP45500.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPQNYLAV IKVIGVGGGG VNAINRMIEV GLKGVEFIAI NTDAQALLMS
60 70 80 90 100
DADVKLDVGR ELTRGLGAGA NPAVGRKAAE DHREEIEEVL KGADMVFVTA
110 120 130 140 150
GEGGGTGTGG APVVANIARS LGALTIGVVT RPFTFEGRRR ANQAEDGIAE
160 170 180 190 200
LREEVDTLIV IPNDRLLSIS DRQVSVLDAF KSADQVLLSG VQGITDLITT
210 220 230 240 250
PGLINLDFAD VKSVMSEAGS ALMGIGSARG DDRAVAAAEM AISSPLLEAS
260 270 280 290 300
IDGARGVLLS ISGGSDLGLF EINEAAQLVS EAAHPEANII FGAVIDDALG
310 320 330 340 350
DEVRVTVIAA GFDGGQPPSK RDNVLGSSSA KREEPTPARP SESRPSFGSL
360 370 380 390
GSVKPKEEPE PAPVPEPVAD LPVSPPPVPP SRTYSDSAAE ELDVPDFLK
Length:399
Mass (Da):41,095
Last modified:November 1, 1995 - v1
Checksum:iEAD52B04CFBB4D39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10879 Genomic DNA. Translation: AAD10533.1.
AL939111 Genomic DNA. Translation: CAB51991.1.
PIRiS60765.
RefSeqiNP_626341.1. NC_003888.3.
WP_003976733.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB51991; CAB51991; CAB51991.
GeneIDi1097516.
KEGGisco:SCO2082.
PATRICi23733812. VBIStrCoe124346_2115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10879 Genomic DNA. Translation: AAD10533.1.
AL939111 Genomic DNA. Translation: CAB51991.1.
PIRiS60765.
RefSeqiNP_626341.1. NC_003888.3.
WP_003976733.1. NC_003888.3.

3D structure databases

ProteinModelPortaliP45500.
SMRiP45500. Positions 22-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO2082.

Proteomic databases

PRIDEiP45500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB51991; CAB51991; CAB51991.
GeneIDi1097516.
KEGGisco:SCO2082.
PATRICi23733812. VBIStrCoe124346_2115.

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
InParanoidiP45500.
KOiK03531.
OMAiNNAREEL.
OrthoDBiEOG6S7XZG.
PhylomeDBiP45500.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Growth and viability of Streptomyces coelicolor mutant for the cell division gene ftsZ."
    McCormick J.R., Su E.P., Driks A., Losick R.
    Mol. Microbiol. 14:243-254(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiFTSZ_STRCO
AccessioniPrimary (citable) accession number: P45500
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 20, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.