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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136GTPUniRule annotation1
Binding sitei140GTPUniRule annotation1
Binding sitei184GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 22GTPUniRule annotation5
Nucleotide bindingi105 – 107GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

  • cell septum assembly Source: CACAO

Keywordsi

Biological processCell cycle, Cell division, Septation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:SCO2082
ORF Names:SC4A10.15c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

  • cell division site Source: GO_Central
  • cytoplasm Source: GO_Central
  • division septum Source: CACAO

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001143881 – 399Cell division protein FtsZAdd BLAST399

Proteomic databases

PRIDEiP45500

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO2082

Structurei

3D structure databases

ProteinModelPortaliP45500
SMRiP45500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK Bacteria
COG0206 LUCA
HOGENOMiHOG000049094
InParanoidiP45500
KOiK03531
OMAiMRAVKGI
OrthoDBiPOG091H02KK
PhylomeDBiP45500

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

P45500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPQNYLAV IKVIGVGGGG VNAINRMIEV GLKGVEFIAI NTDAQALLMS
60 70 80 90 100
DADVKLDVGR ELTRGLGAGA NPAVGRKAAE DHREEIEEVL KGADMVFVTA
110 120 130 140 150
GEGGGTGTGG APVVANIARS LGALTIGVVT RPFTFEGRRR ANQAEDGIAE
160 170 180 190 200
LREEVDTLIV IPNDRLLSIS DRQVSVLDAF KSADQVLLSG VQGITDLITT
210 220 230 240 250
PGLINLDFAD VKSVMSEAGS ALMGIGSARG DDRAVAAAEM AISSPLLEAS
260 270 280 290 300
IDGARGVLLS ISGGSDLGLF EINEAAQLVS EAAHPEANII FGAVIDDALG
310 320 330 340 350
DEVRVTVIAA GFDGGQPPSK RDNVLGSSSA KREEPTPARP SESRPSFGSL
360 370 380 390
GSVKPKEEPE PAPVPEPVAD LPVSPPPVPP SRTYSDSAAE ELDVPDFLK
Length:399
Mass (Da):41,095
Last modified:November 1, 1995 - v1
Checksum:iEAD52B04CFBB4D39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10879 Genomic DNA Translation: AAD10533.1
AL939111 Genomic DNA Translation: CAB51991.1
PIRiS60765
RefSeqiNP_626341.1, NC_003888.3
WP_003976733.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB51991; CAB51991; CAB51991
GeneIDi1097516
KEGGisco:SCO2082
PATRICifig|100226.15.peg.2115

Similar proteinsi

Entry informationi

Entry nameiFTSZ_STRCO
AccessioniPrimary (citable) accession number: P45500
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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