Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

8-amino-7-oxononanoate synthase

Gene

ML1217

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.By similarity

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].

Cofactori

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei27 – 271SubstrateBy similarity
Binding sitei130 – 1301SubstrateBy similarity
Binding sitei176 – 1761Pyridoxal phosphateBy similarity
Binding sitei345 – 3451SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-oxononanoate synthase (EC:2.3.1.47)
Short name:
AONS
Alternative name(s):
7-keto-8-amino-pelargonic acid synthase
Short name:
7-KAP synthase
Short name:
KAPA synthase
8-amino-7-ketopelargonate synthase
Alpha-oxoamine synthase
Gene namesi
Ordered Locus Names:ML1217
ORF Names:B1170_C2_196
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3853858-amino-7-oxononanoate synthasePRO_0000163817Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei235 – 2351N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272631.ML1217.

Structurei

3D structure databases

ProteinModelPortaliP45487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 1062Pyridoxal phosphate bindingBy similarity
Regioni201 – 2044Pyridoxal phosphate bindingBy similarity
Regioni232 – 2354Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107EEK. Bacteria.
COG0156. LUCA.
HOGENOMiHOG000221021.
KOiK00652.
OMAiSGTMELH.
OrthoDBiEOG6Q8HZD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVPIETSPL AWLEAVEQQR RGAGLRRSLR PRSAVATELD LASNDYLGLS
60 70 80 90 100
QHPDVIDGGV AALRVWGAGA TGSRLVTGDT ILHHELECEL AEFVGACVGL
110 120 130 140 150
LFSSGYAANL GAVVGLSGPG SLIVSDAYSH ASLVDACRLS RARVVVTPHC
160 170 180 190 200
DVDAVDTALR SCHEERAVVV TESVFSADGV LAPVSELHDV CRRHGALLLV
210 220 230 240 250
DEAHGLGVRG GGRGLVYEVG LAGAPDVVIT TTMSKALGSQ GGAVLGSSAV
260 270 280 290 300
RAHLINTARP FIFDTGLAPA AVGAARAALQ ILKAETWRPE AVLQHARTLA
310 320 330 340 350
KICDLSELPQ SAVVSVVLGD PEVALAAAIA CLDAGVRVGC FRPPTVPAGT
360 370 380
SRLRLTAHAS LDSAKLEVAR RVLTDVLGGC CVARR
Length:385
Mass (Da):39,831
Last modified:November 1, 1995 - v1
Checksum:i0CA37DD1FACC44AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00010 Genomic DNA. Translation: AAA17066.1.
AL583921 Genomic DNA. Translation: CAC31598.1.
PIRiS72702.
RefSeqiNP_301881.1. NC_002677.1.
WP_010908202.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31598; CAC31598; CAC31598.
GeneIDi910326.
KEGGimle:ML1217.
PATRICi18054592. VBIMycLep78757_2236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00010 Genomic DNA. Translation: AAA17066.1.
AL583921 Genomic DNA. Translation: CAC31598.1.
PIRiS72702.
RefSeqiNP_301881.1. NC_002677.1.
WP_010908202.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP45487.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31598; CAC31598; CAC31598.
GeneIDi910326.
KEGGimle:ML1217.
PATRICi18054592. VBIMycLep78757_2236.

Organism-specific databases

LepromaiML1217.

Phylogenomic databases

eggNOGiENOG4107EEK. Bacteria.
COG0156. LUCA.
HOGENOMiHOG000221021.
KOiK00652.
OMAiSGTMELH.
OrthoDBiEOG6Q8HZD.

Enzyme and pathway databases

UniPathwayiUPA00078.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiBIOF_MYCLE
AccessioniPrimary (citable) accession number: P45487
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 11, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.