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Protein

Cell division protein FtsZ 2

Gene

ftsZ2

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei141 – 1411GTPUniRule annotation
Binding sitei145 – 1451GTPUniRule annotation
Binding sitei189 – 1891GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 275GTPUniRule annotation
Nucleotide bindingi110 – 1123GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2660-MONOMER.
SMEL266834:GJF6-2102-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZ 2UniRule annotation
Gene namesi
Name:ftsZ2UniRule annotation
Ordered Locus Names:R02051
ORF Names:SMc04296
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Cell division protein FtsZ 2PRO_0000114374Add
BLAST

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi266834.SMc04296.

Structurei

3D structure databases

ProteinModelPortaliP45484.
SMRiP45484. Positions 14-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiIWGTSVD.
OrthoDBiEOG6S7XZG.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYKKPIIT EMRPKITVIG VGGGGGNAIN NMIAENLQGV DFIAANTDAQ
60 70 80 90 100
ALATSKAERR IQLGAAITEG LGAGSVPDIG NAAAQESIDE IMDHLGGTHM
110 120 130 140 150
CFVTAGMGGG TGTGAAPVIA EAARRAGILT VAVVTKPFSF EGQRRMQTAE
160 170 180 190 200
LGVERLRESA DTVIVIPNQN LFRIADAKTT FADAFMIADR VLYSGVSCIT
210 220 230 240 250
DLIVKEGLMN LDFADVKTVM KGMGRAMMGT GEATGENRAM LAAEAAIANP
260 270 280 290 300
LLDEVSMRGA KGVLVSISGG MDMTLFEVDE AATRIREEVY DEADIVVGAI
310 320 330 340
FDRSLDGTFR VSVVATGLDS NRSAQPTAPE AMNGQTAAAV PSRTLQ
Length:346
Mass (Da):36,120
Last modified:November 2, 2001 - v2
Checksum:iD8301BAF5D527EC7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti314 – 3141Missing in AAA26281 (PubMed:8144471).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25440 Genomic DNA. Translation: AAA26281.1.
AL591688 Genomic DNA. Translation: CAC46630.1.
PIRiS58854.
RefSeqiNP_386157.1. NC_003047.1.
WP_010969666.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC46630; CAC46630; SMc04296.
GeneIDi1233717.
KEGGisme:SMc04296.
PATRICi23633535. VBISinMel96828_3505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25440 Genomic DNA. Translation: AAA26281.1.
AL591688 Genomic DNA. Translation: CAC46630.1.
PIRiS58854.
RefSeqiNP_386157.1. NC_003047.1.
WP_010969666.1. NC_003047.1.

3D structure databases

ProteinModelPortaliP45484.
SMRiP45484. Positions 14-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc04296.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC46630; CAC46630; SMc04296.
GeneIDi1233717.
KEGGisme:SMc04296.
PATRICi23633535. VBISinMel96828_3505.

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiIWGTSVD.
OrthoDBiEOG6S7XZG.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2660-MONOMER.
SMEL266834:GJF6-2102-MONOMER.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rhizobium meliloti contains a novel second homolog of the cell division gene ftsZ."
    Margolin W., Long S.R.
    J. Bacteriol. 176:2033-2043(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiFTSZ2_RHIME
AccessioniPrimary (citable) accession number: P45484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 2, 2001
Last modified: January 20, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.