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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei191GTPUniRule annotation1
Binding sitei195GTPUniRule annotation1
Binding sitei239GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 77GTPUniRule annotation5
Nucleotide bindingi160 – 162GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Septation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:alr3858
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001143371 – 428Cell division protein FtsZAdd BLAST428

Proteomic databases

PRIDEiP45482

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi103690.alr3858

Structurei

3D structure databases

ProteinModelPortaliP45482
SMRiP45482
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK Bacteria
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI
OrthoDBiPOG091H02KK

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

P45482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDNNQELT YRNSQSLGQP GFSLAVNSSN PFNHSGLNFG QNNDSKKISV
60 70 80 90 100
ENNRIGEIVP GRVANIKVIG VGGGGGNAVN RMIESDVSGV EFWSINTDAQ
110 120 130 140 150
ALTLAGAPSR LQIGQKLTRG LGAGGNPAIG QKAAEESRDE IATALEGADL
160 170 180 190 200
VFITAGMGGG TGTGAAPIVA EVAKEMGALT VGVVTRPFVF EGRRRTSQAE
210 220 230 240 250
QGIEGLKSRV DTLIIIPNNK LLEVIPEQTP VQEAFRYADD VLRQGVQGIS
260 270 280 290 300
DIITIPGLVN VDFADVRAVM ADAGSALMGI GVSSGKSRAR EAAIAAISSP
310 320 330 340 350
LLECSIEGAR GVVFNITGGS DLTLHEVNAA AETIYEVVDP NANIIFGAVI
360 370 380 390 400
DDRLQGEVRI TVIATGFTGE IQAAPQQNAA NARVVSAPPK RTPTQTPLTN
410 420
SPAPTPEPKE KSGLDIPDFL QRRRPPKN
Length:428
Mass (Da):44,730
Last modified:January 23, 2002 - v2
Checksum:i853642CA7ACB53D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti386S → A (PubMed:8525061).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31371 Genomic DNA Translation: CAA83241.1
BA000019 Genomic DNA Translation: BAB75557.1
U14408 Genomic DNA Translation: AAA85526.1
PIRiAC2288
JC4289
RefSeqiWP_010997999.1, NC_003272.1

Genome annotation databases

EnsemblBacteriaiBAB75557; BAB75557; BAB75557
KEGGiana:alr3858

Similar proteinsi

Entry informationi

Entry nameiFTSZ_NOSS1
AccessioniPrimary (citable) accession number: P45482
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2002
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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