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P45460

- AMPC_YEREN

UniProt

P45460 - AMPC_YEREN

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Protein
Beta-lactamase
Gene
ampC
Organism
Yersinia enterocolitica
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Acyl-ester intermediate By similarity
Active sitei175 – 1751Proton acceptor By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Cephalosporinase
Gene namesi
Name:ampC
OrganismiYersinia enterocolitica
Taxonomic identifieri630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 388364Beta-lactamase
PRO_0000016966Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP45460.
SMRiP45460. Positions 32-387.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni342 – 3443Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45460-1 [UniParc]FASTAAdd to Basket

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MMKKSIINTL IFTSIATFPL YTLAQTKLTE LQVATIVNNT LTPLLEKQGI    50
PGMAVAVFYD GKPQFFNYGM ADIKAGRPVT ENTLFELGSV SKTFTGVAGE 100
YAMQTGIMNL NDPVTEYAPE LTGSQWKDVK MLHLATYTAG GLPLQLPDSV 150
TDQKSLWQYY QQWQPQWAPG VMRNYSNASI GLFGALAVKR SQLTFENYMK 200
EYVFQPLKLD HTFITIPESM QSNYAWGYKD GQPVRVTLGM LGEEAYGVKS 250
TSQDMVRFMQ ANMDPESLPA GNDKLKEAII ASQSRYFQAG DMFQGLGWEM 300
YSWPINPQGV IADSGNDIAL KPRKVEALVP AQPAVRASWV HKTGATNGFG 350
AYIVFIPEEK VGIVMLANKN YPNPVRVQAA YDILQALR 388
Length:388
Mass (Da):43,111
Last modified:November 1, 1995 - v1
Checksum:i7352BC99129C56DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63149 Genomic DNA. Translation: CAA44850.1.
PIRiB48899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63149 Genomic DNA. Translation: CAA44850.1 .
PIRi B48899.

3D structure databases

ProteinModelPortali P45460.
SMRi P45460. Positions 32-387.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the ampC-ampR region from the chromosome of Yersinia enterocolitica."
    Seoane A., Francia M.V., Garcia Lobo J.M.
    Antimicrob. Agents Chemother. 36:1049-1052(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IP97 / Serotype O:5B.

Entry informationi

Entry nameiAMPC_YEREN
AccessioniPrimary (citable) accession number: P45460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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