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P45460

- AMPC_YEREN

UniProt

P45460 - AMPC_YEREN

Protein

Beta-lactamase

Gene

ampC

Organism
Yersinia enterocolitica
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    • Comment

    Functioni

    This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei175 – 1751Proton acceptorBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase (EC:3.5.2.6)
    Alternative name(s):
    Cephalosporinase
    Gene namesi
    Name:ampC
    OrganismiYersinia enterocolitica
    Taxonomic identifieri630 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 388364Beta-lactamasePRO_0000016966Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP45460.
    SMRiP45460. Positions 32-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni342 – 3443Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-C beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P45460-1 [UniParc]FASTAAdd to Basket

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    MMKKSIINTL IFTSIATFPL YTLAQTKLTE LQVATIVNNT LTPLLEKQGI    50
    PGMAVAVFYD GKPQFFNYGM ADIKAGRPVT ENTLFELGSV SKTFTGVAGE 100
    YAMQTGIMNL NDPVTEYAPE LTGSQWKDVK MLHLATYTAG GLPLQLPDSV 150
    TDQKSLWQYY QQWQPQWAPG VMRNYSNASI GLFGALAVKR SQLTFENYMK 200
    EYVFQPLKLD HTFITIPESM QSNYAWGYKD GQPVRVTLGM LGEEAYGVKS 250
    TSQDMVRFMQ ANMDPESLPA GNDKLKEAII ASQSRYFQAG DMFQGLGWEM 300
    YSWPINPQGV IADSGNDIAL KPRKVEALVP AQPAVRASWV HKTGATNGFG 350
    AYIVFIPEEK VGIVMLANKN YPNPVRVQAA YDILQALR 388
    Length:388
    Mass (Da):43,111
    Last modified:November 1, 1995 - v1
    Checksum:i7352BC99129C56DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63149 Genomic DNA. Translation: CAA44850.1.
    PIRiB48899.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63149 Genomic DNA. Translation: CAA44850.1 .
    PIRi B48899.

    3D structure databases

    ProteinModelPortali P45460.
    SMRi P45460. Positions 32-387.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the ampC-ampR region from the chromosome of Yersinia enterocolitica."
      Seoane A., Francia M.V., Garcia Lobo J.M.
      Antimicrob. Agents Chemother. 36:1049-1052(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: IP97 / Serotype O:5B.

    Entry informationi

    Entry nameiAMPC_YEREN
    AccessioniPrimary (citable) accession number: P45460
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3