P45460 (AMPC_YEREN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-lactamase
EC=3.5.2.6

Alternative name(s):
Cephalosporinase

Gene names

Name:

ampC

Organism

Yersinia enterocolitica

Taxonomic identifier

630 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
Catalytic activity	A beta-lactam + H2O = a substituted beta-amino acid.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the class-C beta-lactamase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Cellular component	Periplasm
Domain	Signal
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	beta-lactamase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 388	364	Beta-lactamase		PRO_0000016966
Regions
	Region	342 – 344	3	Substrate binding By similarity
Sites
	Active site	89	1	Acyl-ester intermediate By similarity
	Active site	175	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45460 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 7352BC99129C56DA	FASTA	388	43,111
	10 20 30 40 50 60 MMKKSIINTL IFTSIATFPL YTLAQTKLTE LQVATIVNNT LTPLLEKQGI PGMAVAVFYD 70 80 90 100 110 120 GKPQFFNYGM ADIKAGRPVT ENTLFELGSV SKTFTGVAGE YAMQTGIMNL NDPVTEYAPE 130 140 150 160 170 180 LTGSQWKDVK MLHLATYTAG GLPLQLPDSV TDQKSLWQYY QQWQPQWAPG VMRNYSNASI 190 200 210 220 230 240 GLFGALAVKR SQLTFENYMK EYVFQPLKLD HTFITIPESM QSNYAWGYKD GQPVRVTLGM 250 260 270 280 290 300 LGEEAYGVKS TSQDMVRFMQ ANMDPESLPA GNDKLKEAII ASQSRYFQAG DMFQGLGWEM 310 320 330 340 350 360 YSWPINPQGV IADSGNDIAL KPRKVEALVP AQPAVRASWV HKTGATNGFG AYIVFIPEEK 370 380 VGIVMLANKN YPNPVRVQAA YDILQALR

References

[1]	"Nucleotide sequence of the ampC-ampR region from the chromosome of Yersinia enterocolitica." Seoane A., Francia M.V., Garcia Lobo J.M. Antimicrob. Agents Chemother. 36:1049-1052(1992) [PubMed: 1510392] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IP97 / Serotype O:5B.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63149 Genomic DNA. Translation: CAA44850.1.
PIR	B48899.
3D structure databases
ProteinModelPortal	P45460.
SMR	P45460. Positions 32-387.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001466. Beta-lactam-related. IPR012338. Beta-lactam/transpept-like. IPR001586. Beta-lactam_class-C_AS. [Graphical view]
Gene3D	G3DSA:3.40.710.10. G3DSA:3.40.710.10. 1 hit.
Pfam	PF00144. Beta-lactamase. 1 hit. [Graphical view]
SUPFAM	SSF56601. PBP_transp_fold. 1 hit.
PROSITE	PS00336. BETA_LACTAMASE_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPC_YEREN

Accession

Primary (citable) accession number: P45460

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	October 19, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program