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Protein

Beta-lactamase

Gene

ampC

Organism
Yersinia enterocolitica
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei175 – 1751Proton acceptorBy similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Cephalosporinase
Gene namesi
Name:ampC
OrganismiYersinia enterocolitica
Taxonomic identifieri630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 388364Beta-lactamasePRO_0000016966Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP45460.
SMRiP45460. Positions 32-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni342 – 3443Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-C beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKKSIINTL IFTSIATFPL YTLAQTKLTE LQVATIVNNT LTPLLEKQGI
60 70 80 90 100
PGMAVAVFYD GKPQFFNYGM ADIKAGRPVT ENTLFELGSV SKTFTGVAGE
110 120 130 140 150
YAMQTGIMNL NDPVTEYAPE LTGSQWKDVK MLHLATYTAG GLPLQLPDSV
160 170 180 190 200
TDQKSLWQYY QQWQPQWAPG VMRNYSNASI GLFGALAVKR SQLTFENYMK
210 220 230 240 250
EYVFQPLKLD HTFITIPESM QSNYAWGYKD GQPVRVTLGM LGEEAYGVKS
260 270 280 290 300
TSQDMVRFMQ ANMDPESLPA GNDKLKEAII ASQSRYFQAG DMFQGLGWEM
310 320 330 340 350
YSWPINPQGV IADSGNDIAL KPRKVEALVP AQPAVRASWV HKTGATNGFG
360 370 380
AYIVFIPEEK VGIVMLANKN YPNPVRVQAA YDILQALR
Length:388
Mass (Da):43,111
Last modified:November 1, 1995 - v1
Checksum:i7352BC99129C56DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63149 Genomic DNA. Translation: CAA44850.1.
PIRiB48899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63149 Genomic DNA. Translation: CAA44850.1.
PIRiB48899.

3D structure databases

ProteinModelPortaliP45460.
SMRiP45460. Positions 32-387.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the ampC-ampR region from the chromosome of Yersinia enterocolitica."
    Seoane A., Francia M.V., Garcia Lobo J.M.
    Antimicrob. Agents Chemother. 36:1049-1052(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IP97 / Serotype O:5B.

Entry informationi

Entry nameiAMPC_YEREN
AccessioniPrimary (citable) accession number: P45460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.