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P45457 (ACEA2_SOYBN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate lyase 2
Short name=ICL 2
Short name=Isocitrase 2
Short name=Isocitratase 2
EC=4.1.3.1
Gene names
Name:ICL2
OrganismGlycine max (Soybean) (Glycine hispida) [Reference proteome]
Taxonomic identifier3847 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Phaseoleae › Glycine

Protein attributes

Sequence length557 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in storage lipid mobilization during the growth of higher plant seedling By similarity.

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Glyoxysome.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentGlyoxysome
Peroxisome
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentglyoxysome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 557›557Isocitrate lyase 2
PRO_0000068812

Regions

Motif555 – 5573Microbody targeting signal Potential

Sites

Active site1951 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P45457 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 486D5CE420B7AD95

FASTA55762,840
        10         20         30         40         50         60 
EAEVAEVQAW WNSERFRLTK RPYTARDVVS LRGNLRQTYA SNEMAKKLWC LLKNHQANGT 

        70         80         90        100        110        120 
ASRTFGALDP VQVTQMAKHL DTIYVSGWQC SATHTTSNEP GPDLADYPYD TVPNKVEHLF 

       130        140        150        160        170        180 
FAQQYHDRKQ REERMRMSRE ERARTPYVDY LRPIIADGDT GFGGTTATVK LCKLFVERGA 

       190        200        210        220        230        240 
AGIHIEDQSS VTKKCGHMAG KVLVAISEHI NRLVAARLQF DVMGVETVLV ARTDAEAANL 

       250        260        270        280        290        300 
IQSNIDTRDH QFILGVTNPN LKGKSLATLM QQGMAAGKSG AELQALEDEW LSKAQLKTLS 

       310        320        330        340        350        360 
EAVVEAIERQ NIGEEEKRRK LNEWMHHSSY ERCLSNEEGR EIAEKLGVRN LFWDWDLPRT 

       370        380        390        400        410        420 
REGFYRFKGS VIASVVRGWA FSPHADVIWM ETASPNVIEC TQFSEGVRSK HPQMMLGYNL 

       430        440        450        460        470        480 
SPSFNWDASG MSDEQMRDFI PKIAKLGYVW QFITVGGLHS NALITSTFAR DFANRGMLAY 

       490        500        510        520        530        540 
VERIQREERN NGVDTLAHQK WAGANYYDRY LKTVQGGVAS TAAMGKGVTE EQFKESWTRP 

       550 
GAVEIDRGSI VVAKARM

« Hide

References

[1]Guex N., Henry H., Widmer F.
Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Maple Arrow.
Tissue: Cotyledon.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L02330 mRNA. Translation: AAA33977.1.
PIRT07632.
UniGeneGma.52.

3D structure databases

ProteinModelPortalP45457.
SMRP45457. Positions 1-517.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Gene expression databases

GenevestigatorP45457.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR000918. Isocitrate_lyase/Pmutase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA2_SOYBN
AccessionPrimary (citable) accession number: P45457
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 29, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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