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Protein

Isocitrate lyase 2

Gene

ICL2

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in storage lipid mobilization during the growth of higher plant seedling.By similarity

Catalytic activityi

Isocitrate = succinate + glyoxylate.By similarity

Cofactori

Mg2+By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571MagnesiumBy similarity
Active sitei195 – 1951Proton acceptorBy similarity
Binding sitei232 – 2321SubstrateBy similarity
Binding sitei454 – 4541SubstrateBy similarity

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase 2By similarity (EC:4.1.3.1By similarity)
Short name:
ICL 2By similarity
Alternative name(s):
Isocitrase 2By similarity
Isocitratsysase 2By similarity
Gene namesi
Name:ICL2
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827 Componenti: Unplaced

Subcellular locationi

  1. Glyoxysome By similarity

GO - Cellular componenti

  1. glyoxysome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 557›557Isocitrate lyase 2PRO_0000068812Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP45457.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP45457.
SMRiP45457. Positions 1-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 883Substrate bindingBy similarity
Regioni196 – 1972Substrate bindingBy similarity
Regioni419 – 4235Substrate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi555 – 5573Microbody targeting signalSequence Analysis

Sequence similaritiesi

Phylogenomic databases

InParanoidiP45457.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P45457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EAEVAEVQAW WNSERFRLTK RPYTARDVVS LRGNLRQTYA SNEMAKKLWC
60 70 80 90 100
LLKNHQANGT ASRTFGALDP VQVTQMAKHL DTIYVSGWQC SATHTTSNEP
110 120 130 140 150
GPDLADYPYD TVPNKVEHLF FAQQYHDRKQ REERMRMSRE ERARTPYVDY
160 170 180 190 200
LRPIIADGDT GFGGTTATVK LCKLFVERGA AGIHIEDQSS VTKKCGHMAG
210 220 230 240 250
KVLVAISEHI NRLVAARLQF DVMGVETVLV ARTDAEAANL IQSNIDTRDH
260 270 280 290 300
QFILGVTNPN LKGKSLATLM QQGMAAGKSG AELQALEDEW LSKAQLKTLS
310 320 330 340 350
EAVVEAIERQ NIGEEEKRRK LNEWMHHSSY ERCLSNEEGR EIAEKLGVRN
360 370 380 390 400
LFWDWDLPRT REGFYRFKGS VIASVVRGWA FSPHADVIWM ETASPNVIEC
410 420 430 440 450
TQFSEGVRSK HPQMMLGYNL SPSFNWDASG MSDEQMRDFI PKIAKLGYVW
460 470 480 490 500
QFITVGGLHS NALITSTFAR DFANRGMLAY VERIQREERN NGVDTLAHQK
510 520 530 540 550
WAGANYYDRY LKTVQGGVAS TAAMGKGVTE EQFKESWTRP GAVEIDRGSI

VVAKARM
Length:557
Mass (Da):62,840
Last modified:November 1, 1995 - v1
Checksum:i486D5CE420B7AD95
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02330 mRNA. Translation: AAA33977.1.
PIRiT07632.
UniGeneiGma.52.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02330 mRNA. Translation: AAA33977.1.
PIRiT07632.
UniGeneiGma.52.

3D structure databases

ProteinModelPortaliP45457.
SMRiP45457. Positions 1-517.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiP45457.

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Gene expression databases

GenevestigatoriP45457.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Guex N., Henry H., Widmer F.
    Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Maple Arrow.
    Tissue: Cotyledon.

Entry informationi

Entry nameiACEA2_SOYBN
AccessioniPrimary (citable) accession number: P45457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.