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Protein

Isocitrate lyase 1

Gene

ICL1

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in storage lipid mobilization during the growth of higher plant seedling.By similarity

Catalytic activityi

Isocitrate = succinate + glyoxylate.By similarity

Cofactori

Mg2+By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571MagnesiumBy similarity
Active sitei195 – 1951Proton acceptorBy similarity
Binding sitei232 – 2321SubstrateBy similarity
Binding sitei455 – 4551SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase 1By similarity (EC:4.1.3.1By similarity)
Short name:
ICL 1By similarity
Alternative name(s):
Isocitrase 1By similarity
Isocitratsysase 1By similarity
Gene namesi
Name:ICL1
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827 Componenti: Unplaced

Subcellular locationi

  • Glyoxysome By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 558›558Isocitrate lyase 1PRO_0000068811Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP45456.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP45456.
SMRiP45456. Positions 1-518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 883Substrate bindingBy similarity
Regioni196 – 1972Substrate bindingBy similarity
Regioni420 – 4245Substrate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi556 – 5583Microbody targeting signalSequence Analysis

Sequence similaritiesi

Phylogenomic databases

InParanoidiP45456.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P45456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EAEVAEVQAW WNSERFRLTK RPYTARDVVS LRGNLRQTYA SNEMAKKLWR
60 70 80 90 100
LLKNHQANGT ASRTFGALDP VQVTQMAKHL DTIYVSGWQC SATHTTSNEP
110 120 130 140 150
GPDLADYPYD TVPNKVEHLF FAQQYHDRKQ KEERMRMSRE ERARTPYVDY
160 170 180 190 200
LRPIIADGDT GFGGTTATVK LCKLFVERGA AGIHIEDQSS VTKKCGHMAG
210 220 230 240 250
KVLVAISEHI NRLVAARLQF DVMGVETVLV ARTDAEAANL IQSNIDTRDH
260 270 280 290 300
QFILGVTNPN LKGKSLATLM QQGMAAGKNG AELQALEDEW LSKAQLKTLS
310 320 330 340 350
EAVVEAIERQ NNIGEEEKRR KLNEWMHHSS YERCLSNEEG REIAEKLGVR
360 370 380 390 400
NLFWDWDLPR TREGFYRFKG SVTASVVRGC AFSPHADVIW METASPNVVE
410 420 430 440 450
CTEFSEGVRS KHPQMMLGYN LSPSFNWDAS GMSDEQMKDF IPKIAKLGYV
460 470 480 490 500
WQFITVGGLH SNALITSTFA RDFANRGMLA YVERIQREER NNGVDTLAHQ
510 520 530 540 550
KWAGANYYDR YLKTVQGGVA STAAMGKGVT EEQFKESWTR SGAVNIDRGS

IVVAKARM
Length:558
Mass (Da):62,845
Last modified:November 1, 1995 - v1
Checksum:i99B5CA5EA24F5DDB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02329 mRNA. Translation: AAA33976.1.
PIRiT07631.
UniGeneiGma.28715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02329 mRNA. Translation: AAA33976.1.
PIRiT07631.
UniGeneiGma.28715.

3D structure databases

ProteinModelPortaliP45456.
SMRiP45456. Positions 1-518.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiP45456.

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Gene expression databases

GenevestigatoriP45456.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Guex N., Henry H., Widmer F.
    Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Maple Arrow.
    Tissue: Cotyledon.

Entry informationi

Entry nameiACEA1_SOYBN
AccessioniPrimary (citable) accession number: P45456
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.