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Protein

Collagenase 3

Gene

MMP13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.12 Publications

Cofactori

Protein has several cofactor binding sites:

Enzyme regulationi

Inhibited by TIMP1, TIMP2 and TIMP3. Inhibited by acetohydroxamic acid and other zinc chelators.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi96 – 961Zinc 2; in inhibited formBy similarity
Metal bindingi128 – 1281Calcium 113 Publications
Metal bindingi162 – 1621Calcium 2; via carbonyl oxygen13 Publications
Metal bindingi172 – 1721Zinc 1; via tele nitrogen12 Publications
Metal bindingi174 – 1741Zinc 112 Publications
Metal bindingi179 – 1791Calcium 313 Publications
Metal bindingi180 – 1801Calcium 3; via carbonyl oxygen13 Publications
Metal bindingi182 – 1821Calcium 3; via carbonyl oxygen13 Publications
Metal bindingi184 – 1841Calcium 3; via carbonyl oxygen13 Publications
Metal bindingi187 – 1871Zinc 1; via tele nitrogen12 Publications
Metal bindingi194 – 1941Calcium 2; via carbonyl oxygen13 Publications
Metal bindingi196 – 1961Calcium 2; via carbonyl oxygen13 Publications
Metal bindingi198 – 1981Calcium 213 Publications
Metal bindingi200 – 2001Zinc 1; via pros nitrogen12 Publications
Metal bindingi202 – 2021Calcium 313 Publications
Metal bindingi203 – 2031Calcium 113 Publications
Metal bindingi205 – 2051Calcium 1; via carbonyl oxygen13 Publications
Metal bindingi205 – 2051Calcium 313 Publications
Metal bindingi222 – 2221Zinc 2; via tele nitrogen; catalytic12 Publications
Active sitei223 – 22311 Publication
Metal bindingi226 – 2261Zinc 2; via tele nitrogen; catalytic12 Publications
Metal bindingi232 – 2321Zinc 2; via tele nitrogen; catalytic12 Publications
Metal bindingi240 – 2401Zinc 2; via carbonyl oxygen; catalytic12 Publications
Metal bindingi291 – 2911Calcium 4; via carbonyl oxygen13 Publications
Metal bindingi293 – 2931Calcium 5; via carbonyl oxygen13 Publications
Metal bindingi335 – 3351Calcium 4; via carbonyl oxygen13 Publications
Metal bindingi337 – 3371Calcium 5; via carbonyl oxygen13 Publications
Metal bindingi383 – 3831Calcium 4; via carbonyl oxygen13 Publications
Metal bindingi385 – 3851Calcium 5; via carbonyl oxygen13 Publications
Metal bindingi432 – 4321Calcium 4; via carbonyl oxygen13 Publications
Metal bindingi434 – 4341Calcium 5; via carbonyl oxygen13 Publications

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • collagen binding Source: UniProtKB
  • metalloendopeptidase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease