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P45448

- NR5A2_MOUSE

UniProt

P45448 - NR5A2_MOUSE

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Protein

Nuclear receptor subfamily 5 group A member 2

Gene

Nr5a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to promoters containing the sequence element 5'-AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei535 – 5351Lipid headgroupBy similarity
Binding sitei539 – 5391Lipid headgroupBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi104 – 17572Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri107 – 12721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16725NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. phospholipid binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  6. steroid hormone receptor activity Source: InterPro
  7. zinc ion binding Source: InterPro

GO - Biological processi

  1. bile acid metabolic process Source: MGI
  2. cholesterol homeostasis Source: MGI
  3. endocrine pancreas development Source: Reactome
  4. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  5. positive regulation of viral genome replication Source: Ensembl
  6. regulation of cell proliferation Source: MGI
  7. regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_208465. Regulation of gene expression in early pancreatic precursor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 5 group A member 2
Alternative name(s):
Liver receptor homolog 1
Short name:
LRH-1
Gene namesi
Name:Nr5a2
Synonyms:Lrh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1346834. Nr5a2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Nuclear receptor subfamily 5 group A member 2PRO_0000053736Add
BLAST

Proteomic databases

PaxDbiP45448.
PRIDEiP45448.

PTM databases

PhosphoSiteiP45448.

Expressioni

Gene expression databases

BgeeiP45448.
CleanExiMM_NR5A2.
ExpressionAtlasiP45448. baseline and differential.
GenevestigatoriP45448.

Interactioni

Subunit structurei

Binds DNA as a monomer (By similarity). Interacts with GRIP1, NCOA2 and NR0B2.By similarity2 Publications

Protein-protein interaction databases

BioGridi204976. 3 interactions.

Structurei

Secondary structure

1
560
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi322 – 3298
Helixi334 – 35118
Beta strandi354 – 3563
Helixi361 – 38121
Helixi385 – 3873
Helixi390 – 41627
Beta strandi419 – 4235
Beta strandi429 – 4313
Helixi432 – 4376
Helixi441 – 45919
Helixi464 – 47512
Helixi486 – 50722
Helixi514 – 5196
Helixi522 – 54120
Helixi549 – 5557
Turni556 – 5583

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PK5X-ray2.40A/B313-560[»]
1ZH7X-ray2.50A/B318-560[»]
3F5CX-ray3.00A313-560[»]
ProteinModelPortaliP45448.
SMRiP45448. Positions 105-268, 318-560.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45448.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni361 – 40949Ligand-bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi176 – 20530FTZ-F1 boxAdd
BLAST

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri107 – 12721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16725NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG240365.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000063718.
HOVERGENiHBG106677.
InParanoidiP45448.
KOiK08027.
OMAiNTFGLMC.
OrthoDBiEOG7BS4B9.
PhylomeDBiP45448.
TreeFamiTF350737.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR016355. Steroidogenic_factor_1.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002530. Nuc_orph_FTZ-F1. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45448-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSASLDTGDF QEFLKHGLTA IASAPGSETR HSPKREEQLR EKRAGLPDRH
60 70 80 90 100
RRPIPARSRL VMLPKVETEA PGLVRSHGEQ GQMPENMQVS QFKMVNYSYD
110 120 130 140 150
EDLEELCPVC GDKVSGYHYG LLTCESCKGF FKRTVQNQKR YTCIENQNCQ
160 170 180 190 200
IDKTQRKRCP YCRFKKCIDV GMKLEAVRAD RMRGGRNKFG PMYKRDRALK
210 220 230 240 250
QQKKALIRAN GLKLEAMSQV IQAMPSDLTS AIQNIHSASK GLPLSHVALP
260 270 280 290 300
PTDYDRSPFV TSPISMTMPP HSSLHGYQPY GHFPSRAIKS EYPDPYSSSP
310 320 330 340 350
ESMMGYSYMD GYQTNSPASI PHLILELLKC EPDEPQVQAK IMAYLQQEQS
360 370 380 390 400
NRNRQEKLSA FGLLCKMADQ TLFSIVEWAR SSIFFRELKV DDQMKLLQNC
410 420 430 440 450
WSELLILDHI YRQVAHGKEG TIFLVTGEHV DYSTIISHTE VAFNNLLSLA
460 470 480 490 500
QELVVRLRSL QFDQREFVCL KFLVLFSSDV KNLENLQLVE GVQEQVNAAL
510 520 530 540 550
LDYTVCNYPQ QTEKFGQLLL RLPEIRAISK QAEDYLYYKH VNGDVPYNNL
560
LIEMLHAKRA
Length:560
Mass (Da):64,020
Last modified:May 30, 2000 - v3
Checksum:i186F8C4025934643
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81385 mRNA. Translation: AAA39447.1.
BC137845 mRNA. Translation: AAI37846.1.
CCDSiCCDS15328.1.
PIRiS27874.
RefSeqiNP_109601.1. NM_030676.3.
UniGeneiMm.16794.

Genome annotation databases

EnsembliENSMUST00000027649; ENSMUSP00000027649; ENSMUSG00000026398.
GeneIDi26424.
KEGGimmu:26424.
UCSCiuc007cva.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81385 mRNA. Translation: AAA39447.1 .
BC137845 mRNA. Translation: AAI37846.1 .
CCDSi CCDS15328.1.
PIRi S27874.
RefSeqi NP_109601.1. NM_030676.3.
UniGenei Mm.16794.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PK5 X-ray 2.40 A/B 313-560 [» ]
1ZH7 X-ray 2.50 A/B 318-560 [» ]
3F5C X-ray 3.00 A 313-560 [» ]
ProteinModelPortali P45448.
SMRi P45448. Positions 105-268, 318-560.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204976. 3 interactions.

PTM databases

PhosphoSitei P45448.

Proteomic databases

PaxDbi P45448.
PRIDEi P45448.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027649 ; ENSMUSP00000027649 ; ENSMUSG00000026398 .
GeneIDi 26424.
KEGGi mmu:26424.
UCSCi uc007cva.2. mouse.

Organism-specific databases

CTDi 2494.
MGIi MGI:1346834. Nr5a2.

Phylogenomic databases

eggNOGi NOG240365.
GeneTreei ENSGT00760000118887.
HOGENOMi HOG000063718.
HOVERGENi HBG106677.
InParanoidi P45448.
KOi K08027.
OMAi NTFGLMC.
OrthoDBi EOG7BS4B9.
PhylomeDBi P45448.
TreeFami TF350737.

Enzyme and pathway databases

Reactomei REACT_208465. Regulation of gene expression in early pancreatic precursor cells.

Miscellaneous databases

EvolutionaryTracei P45448.
NextBioi 304453.
PROi P45448.
SOURCEi Search...

Gene expression databases

Bgeei P45448.
CleanExi MM_NR5A2.
ExpressionAtlasi P45448. baseline and differential.
Genevestigatori P45448.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR016355. Steroidogenic_factor_1.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002530. Nuc_orph_FTZ-F1. 1 hit.
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 2 hits.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "LRH-1: a nuclear hormone receptor active in the absence of exogenous ligands."
    Tugwood J.D., Issemann I., Green S.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1."
    Sablin E.P., Krylova I.N., Fletterick R.J., Ingraham H.A.
    Mol. Cell 11:1575-1585(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 313-560, INTERACTION WITH NR0B2 AND GRIP1.
  4. "Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner."
    Li Y., Choi M., Suino K., Kovach A., Daugherty J., Kliewer S.A., Xu H.E.
    Proc. Natl. Acad. Sci. U.S.A. 102:9505-9510(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 318-560 IN COMPLEX WITH NR0B2.

Entry informationi

Entry nameiNR5A2_MOUSE
AccessioniPrimary (citable) accession number: P45448
Secondary accession number(s): B9EHF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3