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Protein

Nuclear receptor subfamily 5 group A member 2

Gene

Nr5a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to promoters containing the sequence element 5'-AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei535Lipid headgroupBy similarity1
Binding sitei539Lipid headgroupBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi104 – 175Nuclear receptorPROSITE-ProRule annotationAdd BLAST72
Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri143 – 167NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • bile acid metabolic process Source: MGI
  • cholesterol homeostasis Source: MGI
  • endocrine pancreas development Source: Reactome
  • epithelial cell differentiation Source: MGI
  • hormone-mediated signaling pathway Source: GO_Central
  • pancreas morphogenesis Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • positive regulation of viral genome replication Source: MGI
  • regulation of cell proliferation Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-210747. Regulation of gene expression in early pancreatic precursor cells.
R-MMU-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 5 group A member 2
Alternative name(s):
Liver receptor homolog 1
Short name:
LRH-1
Gene namesi
Name:Nr5a2
Synonyms:Lrh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1346834. Nr5a2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: Reactome
  • nucleus Source: MGI
  • RNA polymerase II transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537361 – 560Nuclear receptor subfamily 5 group A member 2Add BLAST560

Proteomic databases

PaxDbiP45448.
PRIDEiP45448.

PTM databases

iPTMnetiP45448.
PhosphoSitePlusiP45448.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026398.
CleanExiMM_NR5A2.
ExpressionAtlasiP45448. baseline and differential.
GenevisibleiP45448. MM.

Interactioni

Subunit structurei

Binds DNA as a monomer (By similarity). Interacts with GRIP1, NCOA2 and NR0B2.By similarity2 Publications

Protein-protein interaction databases

BioGridi204976. 3 interactors.
STRINGi10090.ENSMUSP00000027649.

Structurei

Secondary structure

1560
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi322 – 329Combined sources8
Helixi334 – 351Combined sources18
Beta strandi354 – 356Combined sources3
Helixi361 – 381Combined sources21
Helixi385 – 387Combined sources3
Helixi390 – 416Combined sources27
Beta strandi419 – 423Combined sources5
Beta strandi429 – 431Combined sources3
Helixi432 – 437Combined sources6
Helixi441 – 459Combined sources19
Helixi464 – 475Combined sources12
Helixi486 – 507Combined sources22
Helixi514 – 519Combined sources6
Helixi522 – 541Combined sources20
Helixi549 – 555Combined sources7
Turni556 – 558Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PK5X-ray2.40A/B313-560[»]
1ZH7X-ray2.50A/B318-560[»]
3F5CX-ray3.00A313-560[»]
ProteinModelPortaliP45448.
SMRiP45448.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45448.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni361 – 409Ligand-bindingBy similarityAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi176 – 205FTZ-F1 boxAdd BLAST30

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri143 – 167NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4218. Eukaryota.
ENOG410YWC2. LUCA.
GeneTreeiENSGT00850000132285.
HOGENOMiHOG000063718.
HOVERGENiHBG106677.
InParanoidiP45448.
KOiK08027.
OMAiDVPCNNL.
OrthoDBiEOG091G06RK.
PhylomeDBiP45448.
TreeFamiTF350737.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR016355. NR5_fam.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR24086. PTHR24086. 1 hit.
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002530. Nuc_orph_FTZ-F1. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASLDTGDF QEFLKHGLTA IASAPGSETR HSPKREEQLR EKRAGLPDRH
60 70 80 90 100
RRPIPARSRL VMLPKVETEA PGLVRSHGEQ GQMPENMQVS QFKMVNYSYD
110 120 130 140 150
EDLEELCPVC GDKVSGYHYG LLTCESCKGF FKRTVQNQKR YTCIENQNCQ
160 170 180 190 200
IDKTQRKRCP YCRFKKCIDV GMKLEAVRAD RMRGGRNKFG PMYKRDRALK
210 220 230 240 250
QQKKALIRAN GLKLEAMSQV IQAMPSDLTS AIQNIHSASK GLPLSHVALP
260 270 280 290 300
PTDYDRSPFV TSPISMTMPP HSSLHGYQPY GHFPSRAIKS EYPDPYSSSP
310 320 330 340 350
ESMMGYSYMD GYQTNSPASI PHLILELLKC EPDEPQVQAK IMAYLQQEQS
360 370 380 390 400
NRNRQEKLSA FGLLCKMADQ TLFSIVEWAR SSIFFRELKV DDQMKLLQNC
410 420 430 440 450
WSELLILDHI YRQVAHGKEG TIFLVTGEHV DYSTIISHTE VAFNNLLSLA
460 470 480 490 500
QELVVRLRSL QFDQREFVCL KFLVLFSSDV KNLENLQLVE GVQEQVNAAL
510 520 530 540 550
LDYTVCNYPQ QTEKFGQLLL RLPEIRAISK QAEDYLYYKH VNGDVPYNNL
560
LIEMLHAKRA
Length:560
Mass (Da):64,020
Last modified:May 30, 2000 - v3
Checksum:i186F8C4025934643
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81385 mRNA. Translation: AAA39447.1.
BC137845 mRNA. Translation: AAI37846.1.
CCDSiCCDS15328.1.
PIRiS27874.
RefSeqiNP_109601.1. NM_030676.3.
UniGeneiMm.16794.

Genome annotation databases

EnsembliENSMUST00000027649; ENSMUSP00000027649; ENSMUSG00000026398.
GeneIDi26424.
KEGGimmu:26424.
UCSCiuc007cva.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81385 mRNA. Translation: AAA39447.1.
BC137845 mRNA. Translation: AAI37846.1.
CCDSiCCDS15328.1.
PIRiS27874.
RefSeqiNP_109601.1. NM_030676.3.
UniGeneiMm.16794.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PK5X-ray2.40A/B313-560[»]
1ZH7X-ray2.50A/B318-560[»]
3F5CX-ray3.00A313-560[»]
ProteinModelPortaliP45448.
SMRiP45448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204976. 3 interactors.
STRINGi10090.ENSMUSP00000027649.

PTM databases

iPTMnetiP45448.
PhosphoSitePlusiP45448.

Proteomic databases

PaxDbiP45448.
PRIDEiP45448.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027649; ENSMUSP00000027649; ENSMUSG00000026398.
GeneIDi26424.
KEGGimmu:26424.
UCSCiuc007cva.2. mouse.

Organism-specific databases

CTDi2494.
MGIiMGI:1346834. Nr5a2.

Phylogenomic databases

eggNOGiKOG4218. Eukaryota.
ENOG410YWC2. LUCA.
GeneTreeiENSGT00850000132285.
HOGENOMiHOG000063718.
HOVERGENiHBG106677.
InParanoidiP45448.
KOiK08027.
OMAiDVPCNNL.
OrthoDBiEOG091G06RK.
PhylomeDBiP45448.
TreeFamiTF350737.

Enzyme and pathway databases

ReactomeiR-MMU-210747. Regulation of gene expression in early pancreatic precursor cells.
R-MMU-383280. Nuclear Receptor transcription pathway.

Miscellaneous databases

EvolutionaryTraceiP45448.
PROiP45448.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026398.
CleanExiMM_NR5A2.
ExpressionAtlasiP45448. baseline and differential.
GenevisibleiP45448. MM.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR016355. NR5_fam.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR24086. PTHR24086. 1 hit.
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002530. Nuc_orph_FTZ-F1. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNR5A2_MOUSE
AccessioniPrimary (citable) accession number: P45448
Secondary accession number(s): B9EHF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.