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Protein

Putative cryptic C4-dicarboxylate transporter DcuD

Gene

dcuD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in the transport of dicarboxylates from the periplasm across the inner membrane. Seems not to be essential for growth. It is likely to be a cryptic gene, as no or low expression has been found under a number of growth conditions and when tested with a large number of potential substrates.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YHCL-MONOMER.
ECOL316407:JW3196-MONOMER.

Protein family/group databases

TCDBi2.A.61.1.2. the c4-dicarboxylate uptake c (dcuc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cryptic C4-dicarboxylate transporter DcuD
Gene namesi
Name:dcuD
Synonyms:yhcL
Ordered Locus Names:b3227, JW3196
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12818. dcuD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525PeriplasmicSequence analysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence analysisAdd
BLAST
Topological domaini47 – 11165CytoplasmicSequence analysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST
Topological domaini133 – 1331PeriplasmicSequence analysis
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Topological domaini155 – 1595CytoplasmicSequence analysis
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Topological domaini181 – 1899PeriplasmicSequence analysis
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Topological domaini211 – 24535CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence analysisAdd
BLAST
Topological domaini267 – 2693PeriplasmicSequence analysis
Transmembranei270 – 29021HelicalSequence analysisAdd
BLAST
Topological domaini291 – 34757CytoplasmicSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Topological domaini369 – 3779PeriplasmicSequence analysis
Transmembranei378 – 39821HelicalSequence analysisAdd
BLAST
Topological domaini399 – 41113CytoplasmicSequence analysisAdd
BLAST
Transmembranei412 – 43221HelicalSequence analysisAdd
BLAST
Topological domaini433 – 45523PeriplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Putative cryptic C4-dicarboxylate transporter DcuDPRO_0000201632Add
BLAST

Proteomic databases

PaxDbiP45428.
PRIDEiP45428.

Interactioni

Protein-protein interaction databases

BioGridi4261551. 7 interactions.
DIPiDIP-9412N.
IntActiP45428. 2 interactions.
STRINGi511145.b3227.

Structurei

3D structure databases

ProteinModelPortaliP45428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CEE. Bacteria.
COG3069. LUCA.
HOGENOMiHOG000274996.
KOiK03326.
OMAiVFLMMCG.

Family and domain databases

InterProiIPR004669. C4_dicarb_anaerob_car.
IPR018385. C4_dicarb_anaerob_car-like.
[Graphical view]
PfamiPF03606. DcuC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00771. DcuC. 1 hit.

Sequencei

Sequence statusi: Complete.

P45428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGIIISVIV LITMGYLILK NYKPQVVLAA AGIFLMMCGV WLGFGGVLDP
60 70 80 90 100
TKSSGYLIVD IYNEILRMLS NRIAGLGLSI MAVGGYARYM ERIGASRAMV
110 120 130 140 150
SLLSRPLKLI RSPYIILSAT YVIGQIMAQF ITSASGLGML LMVTLFPTLV
160 170 180 190 200
SLGVSRLSAV AVIATTMSIE WGILETNSIF AAQVAGMKIA TYFFHYQLPV
210 220 230 240 250
ASCVIISVAI SHFFVQRAFD KKDKNINHEQ AEQKALDNVP PLYYAILPVM
260 270 280 290 300
PLILMLGSLF LAHVGLMQSE LHLVVVMLLS LTVTMFVEFF RKHNLRETMD
310 320 330 340 350
DVQAFFDGMG TQFANVVTLV VAGEIFAKGL TTIGTVDAVI RGAEHSGLGG
360 370 380 390 400
IGVMIIMALV IAICAIVMGS GNAPFMSFAS LIPNIAAGLH VPAVVMIMPM
410 420 430 440 450
HFATTLARAV SPITAVVVVT SGIAGVSPFA VVKRTAIPMA VGFVVNMIAT

ITLFY
Length:455
Mass (Da):48,831
Last modified:November 1, 1995 - v1
Checksum:i4EC705EFE463FCD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58029.1.
U00096 Genomic DNA. Translation: AAC76259.1.
AP009048 Genomic DNA. Translation: BAE77270.1.
PIRiE65114.
RefSeqiNP_417694.1. NC_000913.3.
WP_000467018.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76259; AAC76259; b3227.
BAE77270; BAE77270; BAE77270.
GeneIDi946575.
KEGGiecj:JW3196.
eco:b3227.
PATRICi32121878. VBIEscCol129921_3323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58029.1.
U00096 Genomic DNA. Translation: AAC76259.1.
AP009048 Genomic DNA. Translation: BAE77270.1.
PIRiE65114.
RefSeqiNP_417694.1. NC_000913.3.
WP_000467018.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP45428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261551. 7 interactions.
DIPiDIP-9412N.
IntActiP45428. 2 interactions.
STRINGi511145.b3227.

Protein family/group databases

TCDBi2.A.61.1.2. the c4-dicarboxylate uptake c (dcuc) family.

Proteomic databases

PaxDbiP45428.
PRIDEiP45428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76259; AAC76259; b3227.
BAE77270; BAE77270; BAE77270.
GeneIDi946575.
KEGGiecj:JW3196.
eco:b3227.
PATRICi32121878. VBIEscCol129921_3323.

Organism-specific databases

EchoBASEiEB2669.
EcoGeneiEG12818. dcuD.

Phylogenomic databases

eggNOGiENOG4105CEE. Bacteria.
COG3069. LUCA.
HOGENOMiHOG000274996.
KOiK03326.
OMAiVFLMMCG.

Enzyme and pathway databases

BioCyciEcoCyc:YHCL-MONOMER.
ECOL316407:JW3196-MONOMER.

Miscellaneous databases

PROiP45428.

Family and domain databases

InterProiIPR004669. C4_dicarb_anaerob_car.
IPR018385. C4_dicarb_anaerob_car-like.
[Graphical view]
PfamiPF03606. DcuC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00771. DcuC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCUD_ECOLI
AccessioniPrimary (citable) accession number: P45428
Secondary accession number(s): Q2M8Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.