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Protein

Putative nuclease YhcG

Gene

yhcG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a nuclease involved in DNA recombination and repair.2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciEcoCyc:G7674-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative nuclease YhcG1 Publication (EC:3.1.-.-Curated)
Gene namesi
Name:yhcG
Ordered Locus Names:b3220, JW3189
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12813 yhcG

Pathology & Biotechi

Disruption phenotypei

Deletion of this gene results in a synthetic-lethal phenotype when combined with hypomorphic alleles of the replicative primosome (dnaB), DNA polymerase III (dnaN), and DNA topoisomerase IV (parE).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001694841 – 375Putative nuclease YhcGAdd BLAST375

Proteomic databases

PaxDbiP45423
PRIDEiP45423

Interactioni

Subunit structurei

Interacts with DNA processing enzymes, including the restriction complex HsdMRS, the integrases IntF and IntS, and the recombinase PinE.1 Publication

Protein-protein interaction databases

BioGridi4262441, 20 interactors
IntActiP45423, 1 interactor
STRINGi316407.85676013

Structurei

3D structure databases

ProteinModelPortaliP45423
SMRiP45423
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Possesses a PD-(D/E)XK-like nuclease domain.1 Publication

Phylogenomic databases

eggNOGiENOG4105DFS Bacteria
COG4804 LUCA
HOGENOMiHOG000097665
InParanoidiP45423
OMAiTFVGRQR
PhylomeDBiP45423

Family and domain databases

InterProiView protein in InterPro
IPR009362 DUF1016
PANTHERiPTHR30547 PTHR30547, 1 hit
PfamiView protein in Pfam
PF06250 DUF1016, 1 hit

Sequencei

Sequence statusi: Complete.

P45423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLSEGTTA GYQQIHDGII HLVDSARTET VRSVNALMTA TYQEIGRRIV
60 70 80 90 100
EFEQGGEARA AYGAQLIKRL SKDLCLRYKR GFSAKNLRQM RLFYLFFQHV
110 120 130 140 150
EIHQTMSGEL TPLGIPQTPS AEFPSAKIWQ TLSAKSFPLP RSTYVRLLSV
160 170 180 190 200
KNADARSFYE KETLRCGWSV RQLERQIATQ FYERTLLSHD KSAMLQQHAP
210 220 230 240 250
AETHILPQQA IRDPFVLEFL ELKDEYSESD FEEALINHLM DFMLELGDDF
260 270 280 290 300
AFVGRQRRLR IDDNWFRVDL LFFHRRLRCL LIVDLKVGKF SYSDAGQMNM
310 320 330 340 350
YLNYAKEHWT LPDENPPIGL VLCAEKGAGE AHYALAGLPN TVLASEYKMQ
360 370
LPDEKRLADE LVRTQAVLEE GYRRR
Length:375
Mass (Da):43,293
Last modified:November 1, 1995 - v1
Checksum:i76F67ABCDA815639
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58022.1
U00096 Genomic DNA Translation: AAC76252.1
AP009048 Genomic DNA Translation: BAE77263.1
PIRiF65113
RefSeqiNP_417687.1, NC_000913.3
WP_000445111.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76252; AAC76252; b3220
BAE77263; BAE77263; BAE77263
GeneIDi947739
KEGGiecj:JW3189
eco:b3220
PATRICifig|511145.12.peg.3316

Similar proteinsi

Entry informationi

Entry nameiYHCG_ECOLI
AccessioniPrimary (citable) accession number: P45423
Secondary accession number(s): Q2M8Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health