P45419 (PGSA_PSEFL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
EC=2.7.8.5

Alternative name(s):
Phosphatidylglycerophosphate synthase
Short name=PGP synthase

Gene names

Name:

pgsA

Organism

Pseudomonas fluorescens

Taxonomic identifier

294 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase		PRO_0000056781
Regions
	Transmembrane	7 – 24	18	Helical; Potential
	Transmembrane	60 – 81	22	Helical; Potential
	Transmembrane	134 – 150	17	Helical; Potential
	Transmembrane	157 – 173	17	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P45419 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: E6234FF3A5574D34	FASTA	195	21,846
	10 20 30 40 50 60 MNIPNLITVL RVLLIPIFIL LFYLPYNWSY MAASSVFAFA AATDWLDGYL ARRLEQSTPF 70 80 90 100 110 120 GAFLDPVADK LMVAVALVLL VQEHGNLWLT LPAAVIIGRE IVVSALREWM AELGRTRPGG 130 140 150 160 170 180 RCPTWANRKT AAQMLALVIL LANPPAFTFW VLLGYAFLLI AGGLTLWSML QYLRAAWPHL 190 KTDGRKEIKL FESRG

References

[1]

"Global regulation of expression of antifungal factors by a Pseudomonas fluorescens biological control strain." Gaffney T.D., Lam S.T., Ligon J., Gates K., Frazelle A., Maio J., Hill S., Goodwin S., Torkewitz N., Allshouse A.M., Kempf H.J., Becker J.O. Mol. Plant Microbe Interact. 7:455-463(1994) [PubMed: 8075420] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BL915.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L29642 Genomic DNA. Translation: AAA98757.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMs	TIGR00560. PgsA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_PSEFL

Accession

Primary (citable) accession number: P45419

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 31, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program