P45416 (KDGK_DICD3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-dehydro-3-deoxygluconokinase
EC=2.7.1.45

Alternative name(s):
2-keto-3-deoxygluconokinase
3-deoxy-2-oxo-D-gluconate kinase
KDG kinase

Gene names

Name:	kdgK
Ordered Locus Names:	Dda3937_02001

Organism

Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) [Complete proteome] [HAMAP]

Taxonomic identifier

198628 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Dickeya

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate.
Pathway	Carbohydrate acid metabolism; 2-dehydro-3-deoxy-D-gluconate degradation; D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 1/2.
Sequence similarities	Belongs to the carbohydrate kinase pfkB family.
Sequence caution	The sequence CAA52961.1 differs from that shown. Reason: Frameshift at position 304.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	2-dehydro-3-deoxygluconokinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	2-dehydro-3-deoxygluconokinase		PRO_0000080086
Experimental info
	Sequence conflict	18 – 24	7	QKGADLN → RKARISI in CAA52961. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P45416 [UniParc]. Last modified November 30, 2010. Version 3. Checksum: A177AD426D73E0B7	FASTA	310	34,119
	10 20 30 40 50 60 MTTKNIAIIG ECMIELSQKG ADLNRGFGGD TLNTAVYISR QVKPDALDVH YVTALGTDSF 70 80 90 100 110 120 SSEMMASWQK EGVKTDLIQR LDNKLPGLYF IETDATGERT FYYWRNDAAA RYWLESPDAD 130 140 150 160 170 180 TISQQLAQFD YIYLSGISLA ILNQASRARL LTVLRACRAN GGKVIFDNNY RPRLWQSKEE 190 200 210 220 230 240 TRQAYSDMLA CTDIAFLTLD DEDMLWGELP VDEVLKRTHG AGVMEVVIKR GADACLVSIQ 250 260 270 280 290 300 GEALLEVPAI KLPKEKVVDT TAAGDSFSAG YLSVRLNGGS AQDAAKRGHL TASTVIQYRG 310 AIIPLEAMPA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of the Erwinia chrysanthemi kdgK gene involved in pectin degradation." Hugouvieux-Cotte-Pattat N., Nasser W., Robert-Baudouy J. J. Bacteriol. 176:2386-2392(1994) [PubMed: 8157608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 3937.
[2]	"Complete genome sequence of Dickeya dadantii 3937." International Erwinia Consortium Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 3937.
[3]	Rudd K.E. Unpublished observations (AUG-1996) Cited for: IDENTIFICATION OF PROBABLE FRAMESHIFT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X75047 Genomic DNA. Translation: CAA52961.1. Frameshift. CP002038 Genomic DNA. Translation: ADM96338.1.
PIR	C55215.
RefSeq	YP_003880895.1. NC_014500.1.
3D structure databases
ProteinModelPortal	P45416.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9731507.
GenomeReviews	Gene locus Dda3937_02001 in contig CP002038_GR.
KEGG	ddd:Dda3937_02001.
PATRIC	42312547. VBIDicDad25310_0127.
Organism-specific databases
CMR	Search...
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-15644.
Family and domain databases
InterPro	IPR011611. Carb/pur_kinase. IPR002173. Carboh/pur_kinase_PfkB_CS. [Graphical view]
KO	K00874.
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PROSITE	PS00583. PFKB_KINASES_1. False negative. PS00584. PFKB_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KDGK_DICD3

Accession

Primary (citable) accession number: P45416
Secondary accession number(s): E0SFG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 30, 2010
Last modified:	January 25, 2012
This is version 61 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program