P45413 (CILA_KLEPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Citrate lyase alpha chain
Short name=Citrase alpha chain
EC=4.1.3.6

Alternative name(s):
Citrate (pro-3S)-lyase alpha chain
Citrate CoA-transferase subunit
EC=2.8.3.10

Gene names

Name:

citF

Organism

Klebsiella pneumoniae

Taxonomic identifier

573 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Represents a citrate:acetyl-ACP transferase.
Catalytic activity	Citrate = acetate + oxaloacetate. Acetyl-CoA + citrate = acetate + (3S)-citryl-CoA.
Subunit structure	Oligomer with a subunit composition of (alpha,beta, gamma)6.
Subcellular location	Cytoplasm.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Lyase Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	citrate lyase complex Inferred from electronic annotation. Source: InterPro
Molecular function	citrate (pro-3S)-lyase activity Inferred from electronic annotation. Source: EC citrate CoA-transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Citrate lyase alpha chain		PRO_0000089754

Sequences

	Sequence		Length	Mass (Da)
	P45413 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 8E7442046F4A573A	FASTA	508	54,668
	10 20 30 40 50 60 MKETVAMLNQ QYVMPNGLTP YAGVTAKSPW LASESEKRQR KICDSLETAI RRSGLQNGMT 70 80 90 100 110 120 ISFHHAFRGG DKVVNMVVAK LAEMGFRDLT LASSSLIDAH WPLIEHIKNG VIRQIYTSGL 130 140 150 160 170 180 RGKLGEEISA GLMENPVQIH SHGGRVQLIQ SGELSIDVAF LGVPCCDEFG NANGFSGKSR 190 200 210 220 230 240 CGSLGYARVD AEHAKCVVLL TEEWVDYPNY PASIAQDQVD LIVQVDEVGD PQKITAGAIR 250 260 270 280 290 300 LTSNPRELLI ARQAAKVVEH SGYFKEGFSL QTGTGGASLA VTRFLEDKMR RNGITASFGL 310 320 330 340 350 360 GGITGTMVDL HEKGLIKTLL DTQSFDGDAA RSLAQNPNHV EISTNQYASP GSKGASCERL 370 380 390 400 410 420 NVVMLSALEI DIDFNVNVMT GSNGVLRGAS GGHSDTAAGA DLTIITAPLV RGRIPCVVEK 430 440 450 460 470 480 VLTRVTPGAS VDVLVTDHGI AVNPARQDLI DNLRSAGIPL MTIEELQQRA ELLTGKPQPI 490 500 EFTDRVVAVV RYRDGSVIDV IRQVKNSD

References

[1]	"Klebsiella pneumoniae genes for citrate lyase and citrate lyase ligase: localization, sequencing, and expression." Bott M., Dimroth P. Mol. Microbiol. 14:347-356(1994) [PubMed: 7830578] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 13882 / NBRC 13541 / NCTC 8172.
[2]	"Subunit and chemical composition of citrate lyase from Klebsiella pneumoniae." Singh M., Srere P.A., Klapper D.G., Capra J.D. J. Biol. Chem. 251:2911-2915(1976) [PubMed: 773936] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X79817 Genomic DNA. Translation: CAA56217.1.
PIR	S60776.
3D structure databases
ProteinModelPortal	P45413.
SMR	P45413. Positions 1-505.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR006472. Citrate_lyase_asu. [Graphical view]
Pfam	PF04223. CitF. 1 hit. [Graphical view]
PIRSF	PIRSF009451. Citrt_lyas_alpha. 1 hit.
TIGRFAMs	TIGR01584. CitF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CILA_KLEPN

Accession

Primary (citable) accession number: P45413

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 31, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program