Reviewed,
UniProtKB/Swiss-Prot P45409 (CYCY_RHILV)
Last modified
June 16, 2009.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Thiol:disulfide interchange protein cycY Alternative name(s): Cytochrome c biogenesis protein cycY | ||
| Gene names |
| ||
| Organism | Rhizobium leguminosarum bv. viciae | ||
| Taxonomic identifier | 387 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium |
Protein attributes
| Sequence length | 186 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Required for disulfide bond formation in some periplasmic proteins. Also act as a disulfide oxidoreductase in cytochromes c biogenesis. The cysteines of apocytochromes c must be in the reduced state for covalent linkage between the two moieties to occur By similarity. |
| Subcellular location | Periplasm Probable. |
| Sequence similarities | Belongs to the thioredoxin family. DsbE subfamily. Contains 1 thioredoxin domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cytochrome c-type biogenesis |
| Cellular component | Periplasm |
| Domain | Redox-active center Signal |
| PTM | Disulfide bond |
| Gene Ontology (GO) | |
| Biological process | cell redox homeostasis Inferred from electronic annotation. Source: InterPro cytochrome complex assemblyInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro |
| Molecular function | disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Potential | ||||||||
| Chain | 21 – 186 | 166 | Thiol:disulfide interchange protein cycY | PRO_0000034288 | |||||||
Regions | |||||||||||
| Domain | 47 – 182 | 136 | Thioredoxin | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 80 ↔ 83 | Redox-active By similarity | |||||||||
Sequences
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References
| [1] | "Identification of a gene encoding a thioredoxin-like product necessary for cytochrome c biosynthesis and symbiotic nitrogen fixation in Rhizobium leguminosarum." Vargas C., Wu G., Davies A.E., Downie J.A. J. Bacteriol. 176:4117-4123(1994) [PubMed: 8021193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 8401. |
Cross-references
Sequence databases | |
|---|---|
| X79307 Genomic DNA. Translation: CAB61632.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KNG based on UniProtKB P30960. |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR004799. periplasmic_diS_OxRdtase_DsbE. IPR013740. Redoxin. IPR017936. Thioredoxin-like. IPR015467. Thioredoxin_core. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| PANTHER | PTHR10438. Trx. 1 hit. |
| Pfam | PF08534. Redoxin. 1 hit. [Graphical view] |
| ProDom | PD003679. Thioredoxin_like. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00385. dsbE. 1 hit. |
| PROSITE | PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CYCY_RHILV | ||||||||
| Accession | Primary (citable) accession number: P45409 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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