Reviewed, UniProtKB/Swiss-Prot P45409 (CYCY_RHILV)

Names and origin

Protein names

Recommended name:
    Thiol:disulfide interchange protein cycY
Alternative name(s):
    Cytochrome c biogenesis protein cycY

Gene names

Name:

cycY

Organism

Rhizobium leguminosarum bv. viciae

Taxonomic identifier

387 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for disulfide bond formation in some periplasmic proteins. Also act as a disulfide oxidoreductase in cytochromes c biogenesis. The cysteines of apocytochromes c must be in the reduced state for covalent linkage between the two moieties to occur By similarity.
Subcellular location	Periplasm Probable.
Sequence similarities	Belongs to the thioredoxin family. DsbE subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 186	166	Thiol:disulfide interchange protein cycY		PRO_0000034288
Regions
	Domain	47 – 182	136	Thioredoxin
Amino acid modifications
	Disulfide bond	80 ↔ 83		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45409-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 7A0EC95D5B906E26	FASTA	186	19,836
	10 20 30 40 50 60 MGRYTLALLP LIVFGGIAHG AKMLYDQDFH GKNIAEIPSA LSHQGADAEP AAARRATLPA 70 80 90 100 110 120 LTDAAIKGKL TLVNVFASWC LPCRDEHPVL KELAKDGRLN IVAINYKDQS DNALRFLGEL 130 140 150 160 170 180 GNPYQAIGID PNGKAAIDWG VYGIPESYLV GADGTILYKR VGPSTNISLK EGLVPAMEKA LGKPVS

References

[1]

"Identification of a gene encoding a thioredoxin-like product necessary for cytochrome c biosynthesis and symbiotic nitrogen fixation in Rhizobium leguminosarum." Vargas C., Wu G., Davies A.E., Downie J.A. J. Bacteriol. 176:4117-4123(1994) [PubMed: 8021193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 8401.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X79307 Genomic DNA. Translation: CAB61632.1.
3D structure databases
HSSP	HSSP built from PDB template 1KNG based on UniProtKB P30960.
ModBase	Search...
Family and domain databases
InterPro	IPR004799. periplasmic_diS_OxRdtase_DsbE. IPR013740. Redoxin. IPR017936. Thioredoxin-like. IPR015467. Thioredoxin_core. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR10438. Trx. 1 hit.
Pfam	PF08534. Redoxin. 1 hit. [Graphical view]
ProDom	PD003679. Thioredoxin_like. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00385. dsbE. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYCY_RHILV

Accession

Primary (citable) accession number: P45409

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)