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P45386 (IGA4_HAEIF) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin A1 protease autotransporter
EC=3.4.21.72

Cleaved into the following 2 chains:

  1. Immunoglobulin A1 protease
    Short name=IGA1 protease
  2. Immunoglobulin A1 protease translocator
    Alternative name(s):
    Helper peptide
Gene names
Name:iga
OrganismHaemophilus influenzae
Taxonomic identifier727 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length1849 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Virulence factor; cleaves host immunoglobulin A producing intact Fc and Fab fragments.

Catalytic activity

Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known.

Subcellular location

Immunoglobulin A1 protease autotransporter: Periplasm By similarity.

Immunoglobulin A1 protease: Secreted. Cell surface.

Immunoglobulin A1 protease translocator: Cell outer membrane; Multi-pass membrane protein By similarity. Note: The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane By similarity.

Domain

The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage By similarity.

Sequence similarities

Contains 1 autotransporter (TC 1.B.12) domain. [View classification]

Contains 1 peptidase S6 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 18491824Immunoglobulin A1 protease autotransporter
PRO_0000387602
Chain26 – 1021996Immunoglobulin A1 protease
PRO_0000026966
Chain1022 – 1849828Immunoglobulin A1 protease translocator Potential
PRO_0000026967

Regions

Domain1597 – 1849253Autotransporter

Sites

Active site2991 Probable

Sequences

Sequence LengthMass (Da)Tools
P45386 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 79A7D018C7150AEA

FASTA1,849202,957
        10         20         30         40         50         60 
MLNKKFKLNF IALTVAYALT PYTEAALVRD DVDYQIFRDF AENKGKFSVG ATNVEVRDKK 

        70         80         90        100        110        120 
NQSLGSALPN GIPMIDFSVV DVDKRIATLV NPQYVVGVKH VSNGVSELHF GNLNGNMNNG 

       130        140        150        160        170        180 
NAKSHRDVSS EENRYYTVEK NNFPTENVTS FTTKEEQDAQ KRREDYYMPR LDKFVTEVAP 

       190        200        210        220        230        240 
IEASTANNNK GEYNNSDKYP AFVRLGSGSQ FIYKKGSRYQ LILTEKDKQG NLLRNWDVGG 

       250        260        270        280        290        300 
DNLELVGNAY TYGIAGTPYK VNHENNGLIG FGNSKEEHSD PKGILSQDPL TNYAVLGDSG 

       310        320        330        340        350        360 
SPLFVYDREK GKWLFLGSYD FWAGYNKKSW QEWNIYKHEF AEKIYQQYSA GSLTGSNTQY 

       370        380        390        400        410        420 
TWQATGSTST ITGGGEPLSV DLTDGKDKPN HGKSITLKGS GTLTLNNHID QGAGGLFFEG 

       430        440        450        460        470        480 
DYEVKGTSDS TTWKGAGVSV ADGKTVTWKV HNPKYDRLAK IGKGTLVVEG KGKNEGLLKV 

       490        500        510        520        530        540 
GDGTVILKQK ADANNKVQAF SQVGIVSGRS TLVLNDDKQV DPNSIYFGFR GGRLDLNGNS 

       550        560        570        580        590        600 
LTFDHIRNID DGARVVNHNM TNTSNITITG ESLITNPNTI TSYNIEAQDD DHPLRIRSIP 

       610        620        630        640        650        660 
YRQLYFNQDN RSYYTLKKGA STRSELPQNS GESNENWLYM GRTSDEAKRN VMNHINNERM 

       670        680        690        700        710        720 
NGFNGYFGEE ETKATQNGKL NVTFNGKSDQ NRFLLTGGTN LNGDLNVEKG TLFLSGRPTP 

       730        740        750        760        770        780 
HARDIAGISS TKKDPHFTEN NEVVVEDDWI NRNFKATTMN VTGNASLYSG RNVANITSNI 

       790        800        810        820        830        840 
TASNNAQVHI GYKTGDTVCV RSDYTGYVTC HNSNLSEKAL NSFNPTNLRG NVNLTENASF 

       850        860        870        880        890        900 
TLGKANLFGT IQSIGTSQVN LKENSHWHLT GNSNVNQLNL TNGHIHLNAQ NDANKVTTYN 

       910        920        930        940        950        960 
TLTVNSLSGN GSFYYWVDFT NNKSNKVVVN KSATGNFTLQ VADKTGEPNH NELTLFDASN 

       970        980        990       1000       1010       1020 
ATRNNLEVTL ANGSVDRGAW KYKLRNVNGR YDLYNPEVEK RNQTVDTTNI TTPNDIQADA 

      1030       1040       1050       1060       1070       1080 
PSAQSNNEEI ARVETPVPPP APATESAIAS EQPETRPAET AQPAMEETNT ANSTETAPKS 

      1090       1100       1110       1120       1130       1140 
DTATQTENPN SESVPSETTE KVAENPPQEN ETVAKNEQEA TEPTPQNGEV AKEDQPTVEA 

      1150       1160       1170       1180       1190       1200 
NTQTNEATQS EGKTEETQTA ETKSEPTESV TVSENQPEKT VSQSTEDKVV VEKEEKAKVE 

      1210       1220       1230       1240       1250       1260 
TEETQKAPQV TSKEPPKQAE PAPEEVPTDT NAEEAQALQQ TQPTTVAAAE TTSPNSKPAE 

      1270       1280       1290       1300       1310       1320 
ETQQPSEKTN AEPVTPVVSE NTATQPTETE ETAKVEKEKT QEVPQVASQE SPKQEQPAAK 

      1330       1340       1350       1360       1370       1380 
PQAQTKPQAE PARENVLTTK NVGEPQPQAQ PQTQSTAVPT TGETAANSKP AAKPQAQAKP 

      1390       1400       1410       1420       1430       1440 
QTEPARENVS TVNTKEPQSQ TSATVSTEQP AKETSSNVEQ PAPENSINTG SATTMTETAE 

      1450       1460       1470       1480       1490       1500 
KSDKPQMETV TENDRQPEAN TVADNSVANN SESSESKSRR RRSVSQPKET SAEETTVAST 

      1510       1520       1530       1540       1550       1560 
QETTVDNSVS TPKPRSRRTR RSVQTNSYEP VELPTENAEN AENVQSGNNV ANSQPALRNL 

      1570       1580       1590       1600       1610       1620 
TSKNTNAVLS NAMAKAQFVA LNVGKAVSQH ISQLEMNNEG QYNVWISNTS MNKNYSSEQY 

      1630       1640       1650       1660       1670       1680 
RRFSSKSTQT QLGWDQTISN NVQLGGVFTY VRNSNNFDKA SSKNTLAQVN FYSKYYADNH 

      1690       1700       1710       1720       1730       1740 
WYLGIDLGYG KFQSNLQTNN NAKFARHTAQ IGLTAGKAFN LGNFAVKPTV GVRYSYLSNA 

      1750       1760       1770       1780       1790       1800 
DFALAQDRIK VNPISVKTAF AQVDLSYTYH LGEFSITPIL SARYDANQGN GKINVSVYDF 

      1810       1820       1830       1840 
AYNVENQQQY NAGLKLKYHN VKLSLIGGLT KAKQAEKQKT AEVKLSFSF

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References

[1]"A comparative genetic study of serologically distinct Haemophilus influenzae type 1 immunoglobulin A1 proteases."
Poulsen K., Reinholdt J., Kilian M.
J. Bacteriol. 174:2913-2921(1992) [PubMed: 1373717] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NHTI HK61.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M87491 Genomic DNA. Translation: AAA24968.1.
PIRC41859.

3D structure databases

ProteinModelPortalP45386.
ModBaseSearch...

Protein family/group databases

MEROPSS06.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR005546. Auto_transptbeta.
IPR011250. OMP_b-brl.
IPR012332. P22_tailspike_C-like.
IPR011050. Pectin_lyase_fold/virulence.
IPR000710. Peptidase_S6.
IPR004899. Pertactin_central.
[Graphical view]
Gene3DG3DSA:2.40.160.20. OMP_b-brl. 1 hit.
G3DSA:2.160.20.20. P22_tailspike. 1 hit.
PfamPF03797. Autotransporter. 1 hit.
PF02395. Peptidase_S6. 1 hit.
PF03212. Pertactin. 1 hit.
[Graphical view]
PRINTSPR00921. IGASERPTASE.
SMARTSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMSSF103515. Auto_transptbeta. 1 hit.
SSF51126. Pectin_lyas_like. 1 hit.
PROSITEPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIGA4_HAEIF
AccessionPrimary (citable) accession number: P45386
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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