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P45384 (IGA2_HAEIF) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin A1 protease autotransporter
EC=3.4.21.72

Cleaved into the following 2 chains:

  1. Immunoglobulin A1 protease
    Short name=IGA1 protease
  2. Immunoglobulin A1 protease translocator
    Alternative name(s):
    Helper peptide
Gene names
Name:iga
OrganismHaemophilus influenzae
Taxonomic identifier727 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length1702 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Virulence factor; cleaves host immunoglobulin A producing intact Fc and Fab fragments.

Catalytic activity

Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known.

Subcellular location

Immunoglobulin A1 protease autotransporter: Periplasm By similarity.

Immunoglobulin A1 protease: Secreted. Cell surface.

Immunoglobulin A1 protease translocator: Cell outer membrane; Multi-pass membrane protein By similarity. Note: The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane By similarity.

Domain

The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage By similarity.

Sequence similarities

Contains 1 autotransporter (TC 1.B.12) domain. [View classification]

Contains 1 peptidase S6 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 17021677Immunoglobulin A1 protease autotransporter
PRO_0000387600
Chain26 – 1014989Immunoglobulin A1 protease
PRO_0000026962
Chain1015 – 1702688Immunoglobulin A1 protease translocator Potential
PRO_0000026963

Regions

Repeat1109 – 111681
Repeat1117 – 112482
Domain1450 – 1702253Autotransporter
Region1109 – 1124162 X 8 AA tandem repeats of A-K-V-E-K-E-E-K

Sites

Active site2881 Probable

Sequences

Sequence LengthMass (Da)Tools
P45384 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 860F70D2667807A6

FASTA1,702186,539
        10         20         30         40         50         60 
MLNKKFKLNF IALTVAYALT PYTEAALVRD DVDYQIFRDF AENKGRFSVG ATNVEVRDKN 

        70         80         90        100        110        120 
NHSLGNVLPN GIPMIDFSVV DVDKRIATLI NPQYVVGVKH VSNGVSELHF GNLNGNMNNG 

       130        140        150        160        170        180 
NDKSHRDVSS EENRYFSVEK NEYPTKLNGK AVTTEDQTQK RREDYYMPRL DKFVTEVAPI 

       190        200        210        220        230        240 
EASTASSDAG TYNDQNKYPA FVRLGSGSQF IYKKGDNYSL ILNNHEVGGN NLKLVGDAYT 

       250        260        270        280        290        300 
YGIAGTPYKV NHENNGLIGF GNSKEEHSDP KGILSQDPLT NYAVLGDSGS PLFVYDREKG 

       310        320        330        340        350        360 
KWLFLGSYDF WAGYNKKSWQ EWNIYKPEFA KTVLDKDTAG SLTGSNTQYN WNPTGKTSVI 

       370        380        390        400        410        420 
SNGSESLNVD LFDSSQDTDS KKNNHGKSVT LRGSGTLTLN NNIDQGAGGL FFEGDYEVKG 

       430        440        450        460        470        480 
TSDSTTWKGA GVSVADGKTV TWKVHNPKSD RLAKIGKGTL IVEGKGENKG SLKVGDGTVI 

       490        500        510        520        530        540 
LKQQADANNK VKAFSQVGIV SGRSTVVLND DKQVDPNSIY FGFRGGRLDA NGNNLTFEHI 

       550        560        570        580        590        600 
RNIDDGARLV NHNTSKTSTV TITGESLITD PNTITPYNID APDEDNPYAF RRIKDGGQLY 

       610        620        630        640        650        660 
LNLENYTYYA LRKGASTRSE LPKNSGESNE NWLYMGKTSD EAKRNVMNHI NNERMNGFNG 

       670        680        690        700        710        720 
YFGEEEGKNN GNLNVTFKGK SEQNRFLLTG GTNLNGDLKV EKGTLFLSGR PTPHARDIAG 

       730        740        750        760        770        780 
ISSTKKDQHF AENNEVVVED DWINRNFKAT NINVTNNATL YSGRNVANIT SNITASDNAK 

       790        800        810        820        830        840 
VHIGYKAGDT VCVRSDYTGY VTCTTDKLSD KALNSFNATN VSGNVNLSGN ANFVLGKANL 

       850        860        870        880        890        900 
FGTISGTGNS QVRLTENSHW HLTGDSNVNQ LNLDKGHIHL NAQNDANKVT TYNTLTVNSL 

       910        920        930        940        950        960 
SGNGSFYYLT DLSNKQGDKV VVTKSATGNF TLQVADKTGE PTKNELTLFD ASNATRNNLN 

       970        980        990       1000       1010       1020 
VSLVGNTVDL GAWKYKLRNV NGRYDLYNPE VEKRNQTVDT TNITTPNNIQ ADVPSVPSNN 

      1030       1040       1050       1060       1070       1080 
EEIARVETPV PPPAPATPSE TTETVAENSK QESKTVEKNE QDATETTAQN GEVAEEAKPS 

      1090       1100       1110       1120       1130       1140 
VKANTQTNEV AQSGSETEET QTTEIKETAK VEKEEKAKVE KEEKAKVEKD EIQEAPQMAS 

      1150       1160       1170       1180       1190       1200 
ETSPKQAKPA PKEVSTDTKV EETQVQAQPQ TQSTTVAAAE ATSPNSKPAE ETQPSEKTNA 

      1210       1220       1230       1240       1250       1260 
EPVTPVVSKN QTENTTDQPT EREKTAKVET EKTQEPPQVA SQASPKQEQS ETVQPQAVLE 

      1270       1280       1290       1300       1310       1320 
SENVPTVNNA EEVQAQLQTQ TSATVSTKQP APENSINTGS ATAITETAEK SDKPQTETAA 

      1330       1340       1350       1360       1370       1380 
STEDASQHKA NTVADNSVAN NSESSEPKSR RRRSISQPQE TSAEETTAAS TDETTIADNS 

      1390       1400       1410       1420       1430       1440 
KRSKPNRRSR RSVRSEPTVT NGSDRSTVAL RDLTSTNTNA VISDAMAKAQ FVALNVGKAV 

      1450       1460       1470       1480       1490       1500 
SQHISQLEMN NEGQYNVWVS NTSMNENYSS SQYRRFSSKS TQTQLGWDQT ISNNVQLGGV 

      1510       1520       1530       1540       1550       1560 
FTYVRNSNNF DKASSKNTLA QVNFYSKYYA DNHWYLGIDL GYGKFQSNLK TNHNAKFARH 

      1570       1580       1590       1600       1610       1620 
TAQFGLTAGK AFNLGNFGIT PIVGVRYSYL SNANFALAKD RIKVNPISVK TAFAQVDLSY 

      1630       1640       1650       1660       1670       1680 
TYHLGEFSVT PILSARYDTN QGSGKINVNQ YDFAYNVENQ QQYNAGLKLK YHNVKLSLIG 

      1690       1700 
GLTKAKQAEK QKTAELKLSF SF

« Hide

References

[1]"A comparative genetic study of serologically distinct Haemophilus influenzae type 1 immunoglobulin A1 proteases."
Poulsen K., Reinholdt J., Kilian M.
J. Bacteriol. 174:2913-2921(1992) [PubMed: 1373717] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: HK715 / Serotype B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M87489 Genomic DNA. Translation: AAA24966.1.
PIRA41859.

3D structure databases

ProteinModelPortalP45384.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR005546. Auto_transptbeta.
IPR011250. OMP_b-brl.
IPR012332. P22_tailspike_C-like.
IPR011050. Pectin_lyase_fold/virulence.
IPR000710. Peptidase_S6.
IPR004899. Pertactin_central.
[Graphical view]
Gene3DG3DSA:2.40.160.20. OMP_b-brl. 1 hit.
G3DSA:2.160.20.20. P22_tailspike. 1 hit.
PfamPF03797. Autotransporter. 1 hit.
PF02395. Peptidase_S6. 1 hit.
PF03212. Pertactin. 1 hit.
[Graphical view]
PRINTSPR00921. IGASERPTASE.
SMARTSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMSSF103515. Auto_transptbeta. 1 hit.
SSF51126. Pectin_lyas_like. 1 hit.
PROSITEPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIGA2_HAEIF
AccessionPrimary (citable) accession number: P45384
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 14, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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