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P45380

- S26A1_RAT

UniProt

P45380 - S26A1_RAT

Protein

Sulfate anion transporter 1

Gene

Slc26a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Mediates sulfate and oxalate transport.

    GO - Molecular functioni

    1. anion:anion antiporter activity Source: UniProtKB
    2. chloride transmembrane transporter activity Source: UniProtKB
    3. oxalate transmembrane transporter activity Source: UniProtKB
    4. secondary active sulfate transmembrane transporter activity Source: InterPro
    5. sulfate transmembrane transporter activity Source: RGD

    GO - Biological processi

    1. chloride transmembrane transport Source: GOC
    2. chloride transport Source: GOC
    3. oxalate transport Source: GOC
    4. sulfate transmembrane transport Source: GOC
    5. sulfate transport Source: RGD

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Protein family/group databases

    TCDBi2.A.53.2.2. the sulfate permease (sulp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfate anion transporter 1
    Short name:
    SAT-1
    Alternative name(s):
    Canalicular sulfate transporter
    Solute carrier family 26 member 1
    Sulfate/carbonate antiporter
    Gene namesi
    Name:Slc26a1
    Synonyms:Sat1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620136. Slc26a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 703703Sulfate anion transporter 1PRO_0000080157Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Modified residuei586 – 5861PhosphoserineBy similarity
    Glycosylationi587 – 5871N-linked (GlcNAc...)Sequence Analysis
    Modified residuei589 – 5891PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP45380.
    PRIDEiP45380.

    Expressioni

    Tissue specificityi

    Liver, kidney. Less abundant in muscle and brain.

    Gene expression databases

    GenevestigatoriP45380.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000000047.

    Structurei

    3D structure databases

    ProteinModelPortaliP45380.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei68 – 9023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 27920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei291 – 31323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei416 – 43823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei476 – 49823HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini531 – 689159STASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    HOGENOMiHOG000006546.
    HOVERGENiHBG000639.
    InParanoidiP45380.
    PhylomeDBiP45380.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    TIGRFAMsiTIGR00815. sulP. 1 hit.
    PROSITEiPS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P45380-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDASPEPPQK GGTLVLVRRQ PPVSQGLLET LKARLKKSCT CSMPCAQALV    50
    QGLFPVIRWL PQYRLKEYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY 100
    SLYTSFFANL IYFLMGTSRH VNVGIFSLLC LMVGQVVDRE LQLAGFDPSQ 150
    DSLGPGNNDS TLNNTATLTV GLQDCGRDCH AIRIATALTL MAGLYQVLMG 200
    ILRLGFVSTY LSQPLLDGFA MGASVTILTS QAKHLLGVRI PRHQGLGMVI 250
    HTWLSLLQNV GQANLCDVVT SAVCLAVLLT AKELSDRYRH YLKVPVPTEL 300
    LVIVVATIAS HFGQLHTRFG SSVAGNIPTG FVAPQIPDPK IMWSVALDAM 350
    SLALVGSAFS ISLAEMFARS HGYSVSANQE LLAVGCCNVL PAFFHCFATS 400
    AALSKTLVKI ATGCQTQLSS VVSAAVVLLV LLVLAPLFHD LQRCVLACII 450
    VVSLRGALRK VKDLPQLWRL SPADALVWVA TAATCVLVSI EAGLLAGVFF 500
    SLLSLAGRTQ RPRAALLARI GDSTFYEDAA EFEGLLPPPE VRVFRFTGPL 550
    YYANKDFFLR SLYSLTGLDA GYSATRKDRG TEVGVSNRSL VDRKDLGSVS 600
    SGDGLVVPLA FGFHTVVIDC APLLFLDVAG MATLKDLRKN YRALDITLLL 650
    ACCSPSVRDT LRKGGFLGED QGTAEELLFP SVHSAVETAC ARREELMAAD 700
    SAL 703
    Length:703
    Mass (Da):75,447
    Last modified:November 1, 1995 - v1
    Checksum:iA90D839D70BD2738
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23413 mRNA. Translation: AAA17545.1.
    PIRiA49994.
    UniGeneiRn.10016.

    Genome annotation databases

    UCSCiRGD:620136. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23413 mRNA. Translation: AAA17545.1 .
    PIRi A49994.
    UniGenei Rn.10016.

    3D structure databases

    ProteinModelPortali P45380.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000000047.

    Protein family/group databases

    TCDBi 2.A.53.2.2. the sulfate permease (sulp) family.

    Proteomic databases

    PaxDbi P45380.
    PRIDEi P45380.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:620136. rat.

    Organism-specific databases

    RGDi 620136. Slc26a1.

    Phylogenomic databases

    eggNOGi COG0659.
    HOGENOMi HOG000006546.
    HOVERGENi HBG000639.
    InParanoidi P45380.
    PhylomeDBi P45380.

    Miscellaneous databases

    PROi P45380.

    Gene expression databases

    Genevestigatori P45380.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    TIGRFAMsi TIGR00815. sulP. 1 hit.
    PROSITEi PS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes."
      Bissig M., Hagenbuch B., Stieger B., Koller T., Meier P.J.
      J. Biol. Chem. 269:3017-3021(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiS26A1_RAT
    AccessioniPrimary (citable) accession number: P45380
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3