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P45380

- S26A1_RAT

UniProt

P45380 - S26A1_RAT

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Protein
Sulfate anion transporter 1
Gene
Slc26a1, Sat1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Mediates sulfate and oxalate transport.

GO - Molecular functioni

  1. anion:anion antiporter activity Source: UniProtKB
  2. chloride transmembrane transporter activity Source: UniProtKB
  3. oxalate transmembrane transporter activity Source: UniProtKB
  4. secondary active sulfate transmembrane transporter activity Source: InterPro
  5. sulfate transmembrane transporter activity Source: RGD

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. chloride transport Source: GOC
  3. oxalate transport Source: GOC
  4. sulfate transmembrane transport Source: GOC
  5. sulfate transport Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Protein family/group databases

TCDBi2.A.53.2.2. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate anion transporter 1
Short name:
SAT-1
Alternative name(s):
Canalicular sulfate transporter
Solute carrier family 26 member 1
Sulfate/carbonate antiporter
Gene namesi
Name:Slc26a1
Synonyms:Sat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620136. Slc26a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 9023Helical; Reviewed prediction
Add
BLAST
Transmembranei94 – 11623Helical; Reviewed prediction
Add
BLAST
Transmembranei184 – 20623Helical; Reviewed prediction
Add
BLAST
Transmembranei260 – 27920Helical; Reviewed prediction
Add
BLAST
Transmembranei291 – 31323Helical; Reviewed prediction
Add
BLAST
Transmembranei346 – 36823Helical; Reviewed prediction
Add
BLAST
Transmembranei381 – 40323Helical; Reviewed prediction
Add
BLAST
Transmembranei416 – 43823Helical; Reviewed prediction
Add
BLAST
Transmembranei476 – 49823Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 703703Sulfate anion transporter 1
PRO_0000080157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Modified residuei586 – 5861Phosphoserine By similarity
Glycosylationi587 – 5871N-linked (GlcNAc...) Reviewed prediction
Modified residuei589 – 5891Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP45380.
PRIDEiP45380.

Expressioni

Tissue specificityi

Liver, kidney. Less abundant in muscle and brain.

Gene expression databases

GenevestigatoriP45380.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000047.

Structurei

3D structure databases

ProteinModelPortaliP45380.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini531 – 689159STAS
Add
BLAST

Sequence similaritiesi

Contains 1 STAS domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiP45380.
PhylomeDBiP45380.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45380-1 [UniParc]FASTAAdd to Basket

« Hide

MDASPEPPQK GGTLVLVRRQ PPVSQGLLET LKARLKKSCT CSMPCAQALV    50
QGLFPVIRWL PQYRLKEYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY 100
SLYTSFFANL IYFLMGTSRH VNVGIFSLLC LMVGQVVDRE LQLAGFDPSQ 150
DSLGPGNNDS TLNNTATLTV GLQDCGRDCH AIRIATALTL MAGLYQVLMG 200
ILRLGFVSTY LSQPLLDGFA MGASVTILTS QAKHLLGVRI PRHQGLGMVI 250
HTWLSLLQNV GQANLCDVVT SAVCLAVLLT AKELSDRYRH YLKVPVPTEL 300
LVIVVATIAS HFGQLHTRFG SSVAGNIPTG FVAPQIPDPK IMWSVALDAM 350
SLALVGSAFS ISLAEMFARS HGYSVSANQE LLAVGCCNVL PAFFHCFATS 400
AALSKTLVKI ATGCQTQLSS VVSAAVVLLV LLVLAPLFHD LQRCVLACII 450
VVSLRGALRK VKDLPQLWRL SPADALVWVA TAATCVLVSI EAGLLAGVFF 500
SLLSLAGRTQ RPRAALLARI GDSTFYEDAA EFEGLLPPPE VRVFRFTGPL 550
YYANKDFFLR SLYSLTGLDA GYSATRKDRG TEVGVSNRSL VDRKDLGSVS 600
SGDGLVVPLA FGFHTVVIDC APLLFLDVAG MATLKDLRKN YRALDITLLL 650
ACCSPSVRDT LRKGGFLGED QGTAEELLFP SVHSAVETAC ARREELMAAD 700
SAL 703
Length:703
Mass (Da):75,447
Last modified:November 1, 1995 - v1
Checksum:iA90D839D70BD2738
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23413 mRNA. Translation: AAA17545.1.
PIRiA49994.
UniGeneiRn.10016.

Genome annotation databases

UCSCiRGD:620136. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23413 mRNA. Translation: AAA17545.1 .
PIRi A49994.
UniGenei Rn.10016.

3D structure databases

ProteinModelPortali P45380.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000047.

Protein family/group databases

TCDBi 2.A.53.2.2. the sulfate permease (sulp) family.

Proteomic databases

PaxDbi P45380.
PRIDEi P45380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620136. rat.

Organism-specific databases

RGDi 620136. Slc26a1.

Phylogenomic databases

eggNOGi COG0659.
HOGENOMi HOG000006546.
HOVERGENi HBG000639.
InParanoidi P45380.
PhylomeDBi P45380.

Miscellaneous databases

PROi P45380.

Gene expression databases

Genevestigatori P45380.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
TIGRFAMsi TIGR00815. sulP. 1 hit.
PROSITEi PS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes."
    Bissig M., Hagenbuch B., Stieger B., Koller T., Meier P.J.
    J. Biol. Chem. 269:3017-3021(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiS26A1_RAT
AccessioniPrimary (citable) accession number: P45380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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