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P45380

- S26A1_RAT

UniProt

P45380 - S26A1_RAT

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Protein

Sulfate anion transporter 1

Gene

Slc26a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Mediates sulfate and oxalate transport.

GO - Molecular functioni

  1. anion:anion antiporter activity Source: UniProtKB
  2. chloride transmembrane transporter activity Source: UniProtKB
  3. oxalate transmembrane transporter activity Source: UniProtKB
  4. secondary active sulfate transmembrane transporter activity Source: InterPro
  5. sulfate transmembrane transporter activity Source: RGD

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. chloride transport Source: GOC
  3. oxalate transport Source: GOC
  4. sulfate transmembrane transport Source: GOC
  5. sulfate transport Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Protein family/group databases

TCDBi2.A.53.2.2. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate anion transporter 1
Short name:
SAT-1
Alternative name(s):
Canalicular sulfate transporter
Solute carrier family 26 member 1
Sulfate/carbonate antiporter
Gene namesi
Name:Slc26a1
Synonyms:Sat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620136. Slc26a1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 703703Sulfate anion transporter 1PRO_0000080157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Modified residuei586 – 5861PhosphoserineBy similarity
Glycosylationi587 – 5871N-linked (GlcNAc...)Sequence Analysis
Modified residuei589 – 5891PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP45380.
PRIDEiP45380.

Expressioni

Tissue specificityi

Liver, kidney. Less abundant in muscle and brain.

Gene expression databases

GenevestigatoriP45380.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000047.

Structurei

3D structure databases

ProteinModelPortaliP45380.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 9023HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11623HelicalSequence AnalysisAdd
BLAST
Transmembranei184 – 20623HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 27920HelicalSequence AnalysisAdd
BLAST
Transmembranei291 – 31323HelicalSequence AnalysisAdd
BLAST
Transmembranei346 – 36823HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40323HelicalSequence AnalysisAdd
BLAST
Transmembranei416 – 43823HelicalSequence AnalysisAdd
BLAST
Transmembranei476 – 49823HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini531 – 689159STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiP45380.
PhylomeDBiP45380.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45380 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDASPEPPQK GGTLVLVRRQ PPVSQGLLET LKARLKKSCT CSMPCAQALV
60 70 80 90 100
QGLFPVIRWL PQYRLKEYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY
110 120 130 140 150
SLYTSFFANL IYFLMGTSRH VNVGIFSLLC LMVGQVVDRE LQLAGFDPSQ
160 170 180 190 200
DSLGPGNNDS TLNNTATLTV GLQDCGRDCH AIRIATALTL MAGLYQVLMG
210 220 230 240 250
ILRLGFVSTY LSQPLLDGFA MGASVTILTS QAKHLLGVRI PRHQGLGMVI
260 270 280 290 300
HTWLSLLQNV GQANLCDVVT SAVCLAVLLT AKELSDRYRH YLKVPVPTEL
310 320 330 340 350
LVIVVATIAS HFGQLHTRFG SSVAGNIPTG FVAPQIPDPK IMWSVALDAM
360 370 380 390 400
SLALVGSAFS ISLAEMFARS HGYSVSANQE LLAVGCCNVL PAFFHCFATS
410 420 430 440 450
AALSKTLVKI ATGCQTQLSS VVSAAVVLLV LLVLAPLFHD LQRCVLACII
460 470 480 490 500
VVSLRGALRK VKDLPQLWRL SPADALVWVA TAATCVLVSI EAGLLAGVFF
510 520 530 540 550
SLLSLAGRTQ RPRAALLARI GDSTFYEDAA EFEGLLPPPE VRVFRFTGPL
560 570 580 590 600
YYANKDFFLR SLYSLTGLDA GYSATRKDRG TEVGVSNRSL VDRKDLGSVS
610 620 630 640 650
SGDGLVVPLA FGFHTVVIDC APLLFLDVAG MATLKDLRKN YRALDITLLL
660 670 680 690 700
ACCSPSVRDT LRKGGFLGED QGTAEELLFP SVHSAVETAC ARREELMAAD

SAL
Length:703
Mass (Da):75,447
Last modified:November 1, 1995 - v1
Checksum:iA90D839D70BD2738
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23413 mRNA. Translation: AAA17545.1.
PIRiA49994.
UniGeneiRn.10016.

Genome annotation databases

UCSCiRGD:620136. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23413 mRNA. Translation: AAA17545.1 .
PIRi A49994.
UniGenei Rn.10016.

3D structure databases

ProteinModelPortali P45380.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000047.

Protein family/group databases

TCDBi 2.A.53.2.2. the sulfate permease (sulp) family.

Proteomic databases

PaxDbi P45380.
PRIDEi P45380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620136. rat.

Organism-specific databases

RGDi 620136. Slc26a1.

Phylogenomic databases

eggNOGi COG0659.
HOGENOMi HOG000006546.
HOVERGENi HBG000639.
InParanoidi P45380.
PhylomeDBi P45380.

Miscellaneous databases

PROi P45380.

Gene expression databases

Genevestigatori P45380.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
TIGRFAMsi TIGR00815. sulP. 1 hit.
PROSITEi PS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes."
    Bissig M., Hagenbuch B., Stieger B., Koller T., Meier P.J.
    J. Biol. Chem. 269:3017-3021(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiS26A1_RAT
AccessioniPrimary (citable) accession number: P45380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3