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Protein

Sulfate anion transporter 1

Gene

Slc26a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates sulfate transport with high affinity (PubMed:8300633). Mediates oxalate transport (PubMed:8300633). Mediates bicarbonate transport (By similarity). Does not accept succinate as cosubstrate (PubMed:8300633).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processAnion exchange, Antiport, Ion transport, Transport

Protein family/group databases

TCDBi2.A.53.2.2 the sulfate permease (sulp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate anion transporter 1
Short name:
SAT-1
Alternative name(s):
Canalicular sulfate transporter
Solute carrier family 26 member 1
Sulfate/carbonate antiporter
Gene namesi
Name:Slc26a1
Synonyms:Sat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620136 Slc26a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 90HelicalSequence analysisAdd BLAST23
Transmembranei94 – 116HelicalSequence analysisAdd BLAST23
Transmembranei184 – 206HelicalSequence analysisAdd BLAST23
Transmembranei260 – 279HelicalSequence analysisAdd BLAST20
Transmembranei291 – 313HelicalSequence analysisAdd BLAST23
Transmembranei346 – 368HelicalSequence analysisAdd BLAST23
Transmembranei381 – 403HelicalSequence analysisAdd BLAST23
Transmembranei416 – 438HelicalSequence analysisAdd BLAST23
Transmembranei476 – 498HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801571 – 703Sulfate anion transporter 1Add BLAST703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphothreonineCombined sources1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei586PhosphoserineCombined sources1
Glycosylationi587N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei589PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP45380
PRIDEiP45380

PTM databases

iPTMnetiP45380

Expressioni

Tissue specificityi

Expressed in kidney cortex and medulla, ileum and colon (at protein level) (PubMed:27210743). Expressed in liver and kidney (PubMed:8300633). Less abundant in muscle and brain (PubMed:8300633).2 Publications

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000047

Structurei

3D structure databases

ProteinModelPortaliP45380
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini531 – 689STASPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236 Eukaryota
COG0659 LUCA
HOGENOMiHOG000006546
HOVERGENiHBG000639
InParanoidiP45380
PhylomeDBiP45380

Family and domain databases

InterProiView protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030331 SLC26A1
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PTHR11814:SF31 PTHR11814:SF31, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF52091 SSF52091, 2 hits
TIGRFAMsiTIGR00815 sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

Sequencei

Sequence statusi: Complete.

P45380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDASPEPPQK GGTLVLVRRQ PPVSQGLLET LKARLKKSCT CSMPCAQALV
60 70 80 90 100
QGLFPVIRWL PQYRLKEYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY
110 120 130 140 150
SLYTSFFANL IYFLMGTSRH VNVGIFSLLC LMVGQVVDRE LQLAGFDPSQ
160 170 180 190 200
DSLGPGNNDS TLNNTATLTV GLQDCGRDCH AIRIATALTL MAGLYQVLMG
210 220 230 240 250
ILRLGFVSTY LSQPLLDGFA MGASVTILTS QAKHLLGVRI PRHQGLGMVI
260 270 280 290 300
HTWLSLLQNV GQANLCDVVT SAVCLAVLLT AKELSDRYRH YLKVPVPTEL
310 320 330 340 350
LVIVVATIAS HFGQLHTRFG SSVAGNIPTG FVAPQIPDPK IMWSVALDAM
360 370 380 390 400
SLALVGSAFS ISLAEMFARS HGYSVSANQE LLAVGCCNVL PAFFHCFATS
410 420 430 440 450
AALSKTLVKI ATGCQTQLSS VVSAAVVLLV LLVLAPLFHD LQRCVLACII
460 470 480 490 500
VVSLRGALRK VKDLPQLWRL SPADALVWVA TAATCVLVSI EAGLLAGVFF
510 520 530 540 550
SLLSLAGRTQ RPRAALLARI GDSTFYEDAA EFEGLLPPPE VRVFRFTGPL
560 570 580 590 600
YYANKDFFLR SLYSLTGLDA GYSATRKDRG TEVGVSNRSL VDRKDLGSVS
610 620 630 640 650
SGDGLVVPLA FGFHTVVIDC APLLFLDVAG MATLKDLRKN YRALDITLLL
660 670 680 690 700
ACCSPSVRDT LRKGGFLGED QGTAEELLFP SVHSAVETAC ARREELMAAD

SAL
Length:703
Mass (Da):75,447
Last modified:November 1, 1995 - v1
Checksum:iA90D839D70BD2738
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23413 mRNA Translation: AAA17545.1
PIRiA49994
UniGeneiRn.10016

Genome annotation databases

UCSCiRGD:620136 rat

Similar proteinsi

Entry informationi

Entry nameiS26A1_RAT
AccessioniPrimary (citable) accession number: P45380
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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