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P45380 (S26A1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sulfate anion transporter 1

Short name=SAT-1
Alternative name(s):
Canalicular sulfate transporter
Solute carrier family 26 member 1
Sulfate/carbonate antiporter
Gene names
Name:Slc26a1
Synonyms:Sat1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length703 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Mediates sulfate and oxalate transport.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Liver, kidney. Less abundant in muscle and brain.

Sequence similarities

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]

Contains 1 STAS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 703703Sulfate anion transporter 1
PRO_0000080157

Regions

Transmembrane68 – 9023Helical; Potential
Transmembrane94 – 11623Helical; Potential
Transmembrane184 – 20623Helical; Potential
Transmembrane260 – 27920Helical; Potential
Transmembrane291 – 31323Helical; Potential
Transmembrane346 – 36823Helical; Potential
Transmembrane381 – 40323Helical; Potential
Transmembrane416 – 43823Helical; Potential
Transmembrane476 – 49823Helical; Potential
Domain531 – 689159STAS

Amino acid modifications

Modified residue5861Phosphoserine By similarity
Modified residue5891Phosphoserine By similarity
Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation5871N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P45380 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A90D839D70BD2738

FASTA70375,447
        10         20         30         40         50         60 
MDASPEPPQK GGTLVLVRRQ PPVSQGLLET LKARLKKSCT CSMPCAQALV QGLFPVIRWL 

        70         80         90        100        110        120 
PQYRLKEYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY SLYTSFFANL IYFLMGTSRH 

       130        140        150        160        170        180 
VNVGIFSLLC LMVGQVVDRE LQLAGFDPSQ DSLGPGNNDS TLNNTATLTV GLQDCGRDCH 

       190        200        210        220        230        240 
AIRIATALTL MAGLYQVLMG ILRLGFVSTY LSQPLLDGFA MGASVTILTS QAKHLLGVRI 

       250        260        270        280        290        300 
PRHQGLGMVI HTWLSLLQNV GQANLCDVVT SAVCLAVLLT AKELSDRYRH YLKVPVPTEL 

       310        320        330        340        350        360 
LVIVVATIAS HFGQLHTRFG SSVAGNIPTG FVAPQIPDPK IMWSVALDAM SLALVGSAFS 

       370        380        390        400        410        420 
ISLAEMFARS HGYSVSANQE LLAVGCCNVL PAFFHCFATS AALSKTLVKI ATGCQTQLSS 

       430        440        450        460        470        480 
VVSAAVVLLV LLVLAPLFHD LQRCVLACII VVSLRGALRK VKDLPQLWRL SPADALVWVA 

       490        500        510        520        530        540 
TAATCVLVSI EAGLLAGVFF SLLSLAGRTQ RPRAALLARI GDSTFYEDAA EFEGLLPPPE 

       550        560        570        580        590        600 
VRVFRFTGPL YYANKDFFLR SLYSLTGLDA GYSATRKDRG TEVGVSNRSL VDRKDLGSVS 

       610        620        630        640        650        660 
SGDGLVVPLA FGFHTVVIDC APLLFLDVAG MATLKDLRKN YRALDITLLL ACCSPSVRDT 

       670        680        690        700 
LRKGGFLGED QGTAEELLFP SVHSAVETAC ARREELMAAD SAL 

« Hide

References

[1]"Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes."
Bissig M., Hagenbuch B., Stieger B., Koller T., Meier P.J.
J. Biol. Chem. 269:3017-3021(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L23413 mRNA. Translation: AAA17545.1.
PIRA49994.
UniGeneRn.10016.

3D structure databases

ProteinModelPortalP45380.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000000047.

Protein family/group databases

TCDB2.A.53.2.2. the sulfate permease (sulp) family.

Proteomic databases

PaxDbP45380.
PRIDEP45380.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:620136. rat.

Organism-specific databases

RGD620136. Slc26a1.

Phylogenomic databases

eggNOGCOG0659.
HOGENOMHOG000006546.
HOVERGENHBG000639.
InParanoidP45380.
PhylomeDBP45380.

Gene expression databases

GenevestigatorP45380.

Family and domain databases

Gene3D3.30.750.24. 2 hits.
InterProIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMSSF52091. SSF52091. 2 hits.
TIGRFAMsTIGR00815. sulP. 1 hit.
PROSITEPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP45380.

Entry information

Entry nameS26A1_RAT
AccessionPrimary (citable) accession number: P45380
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families