P45380 (S26A1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sulfate anion transporter 1
Short name=SAT-1

Alternative name(s):
Canalicular sulfate transporter
Solute carrier family 26 member 1
Sulfate/carbonate antiporter

Gene names

Name:	Slc26a1
Synonyms:	Sat1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	703 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Liver, kidney. Less abundant in muscle and brain.
Sequence similarities	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification] Contains 1 STAS domain.

Ontologies

Keywords
Biological process	Antiport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sulfate transport Inferred from direct assay Ref.1. Source: RGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	antiporter activity Inferred from electronic annotation. Source: UniProtKB-KW secondary active sulfate transmembrane transporter activity Inferred from electronic annotation. Source: InterPro sulfate transmembrane transporter activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 703	703	Sulfate anion transporter 1		PRO_0000080157
Regions
	Transmembrane	68 – 90	23	Helical; Potential
	Transmembrane	94 – 116	23	Helical; Potential
	Transmembrane	184 – 206	23	Helical; Potential
	Transmembrane	260 – 279	20	Helical; Potential
	Transmembrane	291 – 313	23	Helical; Potential
	Transmembrane	346 – 368	23	Helical; Potential
	Transmembrane	381 – 403	23	Helical; Potential
	Transmembrane	416 – 438	23	Helical; Potential
	Transmembrane	476 – 498	23	Helical; Potential
	Domain	531 – 689	159	STAS
Amino acid modifications
	Glycosylation	158	1	N-linked (GlcNAc...) Potential
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
	Glycosylation	587	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P45380 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A90D839D70BD2738	FASTA	703	75,447
	10 20 30 40 50 60 MDASPEPPQK GGTLVLVRRQ PPVSQGLLET LKARLKKSCT CSMPCAQALV QGLFPVIRWL 70 80 90 100 110 120 PQYRLKEYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY SLYTSFFANL IYFLMGTSRH 130 140 150 160 170 180 VNVGIFSLLC LMVGQVVDRE LQLAGFDPSQ DSLGPGNNDS TLNNTATLTV GLQDCGRDCH 190 200 210 220 230 240 AIRIATALTL MAGLYQVLMG ILRLGFVSTY LSQPLLDGFA MGASVTILTS QAKHLLGVRI 250 260 270 280 290 300 PRHQGLGMVI HTWLSLLQNV GQANLCDVVT SAVCLAVLLT AKELSDRYRH YLKVPVPTEL 310 320 330 340 350 360 LVIVVATIAS HFGQLHTRFG SSVAGNIPTG FVAPQIPDPK IMWSVALDAM SLALVGSAFS 370 380 390 400 410 420 ISLAEMFARS HGYSVSANQE LLAVGCCNVL PAFFHCFATS AALSKTLVKI ATGCQTQLSS 430 440 450 460 470 480 VVSAAVVLLV LLVLAPLFHD LQRCVLACII VVSLRGALRK VKDLPQLWRL SPADALVWVA 490 500 510 520 530 540 TAATCVLVSI EAGLLAGVFF SLLSLAGRTQ RPRAALLARI GDSTFYEDAA EFEGLLPPPE 550 560 570 580 590 600 VRVFRFTGPL YYANKDFFLR SLYSLTGLDA GYSATRKDRG TEVGVSNRSL VDRKDLGSVS 610 620 630 640 650 660 SGDGLVVPLA FGFHTVVIDC APLLFLDVAG MATLKDLRKN YRALDITLLL ACCSPSVRDT 670 680 690 700 LRKGGFLGED QGTAEELLFP SVHSAVETAC ARREELMAAD SAL

References

[1]

"Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes." Bissig M., Hagenbuch B., Stieger B., Koller T., Meier P.J. J. Biol. Chem. 269:3017-3021(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L23413 mRNA. Translation: AAA17545.1.
IPI	IPI00207298.
PIR	A49994.
UniGene	Rn.10016.
3D structure databases
ProteinModelPortal	P45380.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000000047.
Protein family/group databases
TCDB	2.A.53.2.2. sulfate permease (SulP) family.
Proteomic databases
PaxDb	P45380.
PRIDE	P45380.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:620136. rat.
Organism-specific databases
RGD	620136. Slc26a1.
Phylogenomic databases
eggNOG	COG0659.
HOGENOM	HOG000006546.
HOVERGEN	HBG000639.
InParanoid	P45380.
OrthoDB	EOG4T4CV1.
Gene expression databases
ArrayExpress	P45380.
Genevestigator	P45380.
GermOnline	ENSRNOG00000000041. Rattus norvegicus.
Family and domain databases
Gene3D	3.30.750.24. 2 hits.
InterPro	IPR018045. S04_transporter_CS. IPR002645. STAS_dom. IPR001902. SulP_transpt. IPR011547. Sulph_transpt. [Graphical view]
Pfam	PF01740. STAS. 1 hit. PF00916. Sulfate_transp. 1 hit. [Graphical view]
SUPFAM	SSF52091. STAS. 1 hit.
TIGRFAMs	TIGR00815. sulP. 1 hit.
PROSITE	PS01130. SLC26A. 1 hit. PS50801. STAS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

S26A1_RAT

Accession

Primary (citable) accession number: P45380

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program