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Protein

Troponin T, cardiac muscle

Gene

TNNT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • tropomyosin binding Source: UniProtKB
  • troponin C binding Source: UniProtKB
  • troponin I binding Source: UniProtKB

GO - Biological processi

  • actin crosslink formation Source: Ensembl
  • cardiac muscle contraction Source: Ensembl
  • muscle filament sliding Source: UniProtKB
  • negative regulation of ATPase activity Source: UniProtKB
  • positive regulation of ATPase activity Source: UniProtKB
  • protein heterooligomerization Source: Ensembl
  • regulation of heart contraction Source: UniProtKB
  • regulation of muscle filament sliding speed Source: Ensembl
  • response to calcium ion Source: UniProtKB
  • ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118194-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.
SIGNORiP45379.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, cardiac muscle
Short name:
TnTc
Alternative name(s):
Cardiac muscle troponin T
Short name:
cTnT
Gene namesi
Name:TNNT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11949. TNNT2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • sarcomere Source: BHF-UCL
  • striated muscle thin filament Source: UniProtKB
  • troponin complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Cardiomyopathy, familial hypertrophic 2 (CMH2)14 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:115195
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06725938A → V in CMH2. 1 PublicationCorresponds to variant rs200754249dbSNPEnsembl.1
Natural variantiVAR_01987780F → L in CMH2. 1 Publication1
Natural variantiVAR_00760589I → N in CMH2. 1 PublicationCorresponds to variant rs121964855dbSNPEnsembl.1
Natural variantiVAR_016195102R → L in CMH2. 1 Publication1
Natural variantiVAR_007606102R → Q in CMH2. 1 PublicationCorresponds to variant rs121964856dbSNPEnsembl.1
Natural variantiVAR_016196102R → W in CMH2. 1 PublicationCorresponds to variant rs397516456dbSNPEnsembl.1
Natural variantiVAR_009194104R → L in CMH2. 1 PublicationCorresponds to variant rs397516457dbSNPEnsembl.1
Natural variantiVAR_016197114A → V in CMH2. 1 PublicationCorresponds to variant rs727504245dbSNPEnsembl.1
Natural variantiVAR_007607120F → I in CMH2. 2 PublicationsCorresponds to variant rs121964858dbSNPEnsembl.1
Natural variantiVAR_019878120F → V in CMH2. 1 Publication1
Natural variantiVAR_042747140R → C in CMH2. 1 PublicationCorresponds to variant rs397516463dbSNPEnsembl.1
Natural variantiVAR_007608170Missing in CMH2. 1
Natural variantiVAR_007609173E → K in CMH2. 1 Publication1
Natural variantiVAR_016199189S → F in CMH2. 1 PublicationCorresponds to variant rs727504246dbSNPEnsembl.1
Natural variantiVAR_007610254E → D in CMH2. 1 PublicationCorresponds to variant rs45466197dbSNPEnsembl.1
Natural variantiVAR_019879281N → I in CMH2. 1 Publication1
Natural variantiVAR_007612288R → C in CMH2. 3 PublicationsCorresponds to variant rs121964857dbSNPEnsembl.1
Natural variantiVAR_007613288R → P in CMH2. 2 PublicationsCorresponds to variant rs397516484dbSNPEnsembl.1
Natural variantiVAR_019880296R → C in CMH2. 1 PublicationCorresponds to variant rs367785431dbSNPEnsembl.1
Cardiomyopathy, dilated 1D (CMD1D)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:601494
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043983141R → W in CMD1D. 2 PublicationsCorresponds to variant rs74315380dbSNPEnsembl.1
Natural variantiVAR_016198151R → W in CMD1D. 2 PublicationsCorresponds to variant rs74315379dbSNPEnsembl.1
Natural variantiVAR_022931210Missing in CMD1D. 1 Publication1
Natural variantiVAR_043984215R → L in CMD1D. 1 PublicationCorresponds to variant rs121964860dbSNPEnsembl.1
Natural variantiVAR_043985220Missing in CMD1D. 2 Publications1
Cardiomyopathy, familial restrictive 3 (RCM3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
See also OMIM:612422

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNETi7139.
MalaCardsiTNNT2.
MIMi115195. phenotype.
601494. phenotype.
612422. phenotype.
OpenTargetsiENSG00000118194.
Orphaneti154. Familial isolated dilated cardiomyopathy.
155. Familial isolated hypertrophic cardiomyopathy.
75249. Familial isolated restrictive cardiomyopathy.
54260. Left ventricular noncompaction.
PharmGKBiPA36638.

Chemistry databases

ChEMBLiCHEMBL2095202.

Polymorphism and mutation databases

DMDMi21264536.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861732 – 298Troponin T, cardiac muscleAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine; by CK2By similarity1
Modified residuei189PhosphoserineBy similarity1
Modified residuei204Phosphothreonine; by PKC/PRKCABy similarity1
Modified residuei208Phosphoserine; by PKC/PRKCABy similarity1
Modified residuei213Phosphothreonine; by PKC/PRKCA and RAF1By similarity1
Modified residuei294Phosphothreonine; by PKC/PRKCABy similarity1

Post-translational modificationi

Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP45379.
PeptideAtlasiP45379.
PRIDEiP45379.

2D gel databases

UCD-2DPAGEP45379.

PTM databases

iPTMnetiP45379.
PhosphoSitePlusiP45379.

Expressioni

Tissue specificityi

Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.

Gene expression databases

BgeeiENSG00000118194.
CleanExiHS_TNNT2.
ExpressionAtlasiP45379. baseline and differential.
GenevisibleiP45379. HS.

Organism-specific databases

HPAiCAB015371.
HPA015774.
HPA017888.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MORF4L2Q150143EBI-8485957,EBI-399257

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • tropomyosin binding Source: UniProtKB
  • troponin C binding Source: UniProtKB
  • troponin I binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112993. 8 interactors.
IntActiP45379. 3 interactors.
MINTiMINT-3015968.
STRINGi9606.ENSP00000356286.

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi210 – 225Combined sources16
Helixi236 – 280Combined sources45

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J1DX-ray2.61B/E193-298[»]
1J1EX-ray3.30B/E193-298[»]
4Y99X-ray2.00B193-298[»]
ProteinModelPortaliP45379.
SMRiP45379.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45379.

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

eggNOGiKOG3634. Eukaryota.
ENOG410XS6A. LUCA.
GeneTreeiENSGT00390000013611.
HOGENOMiHOG000231049.
HOVERGENiHBG052790.
InParanoidiP45379.
KOiK12045.
OMAiAVCRQQD.
OrthoDBiEOG091G0U67.
PhylomeDBiP45379.
TreeFamiTF313321.

Family and domain databases

InterProiIPR027707. TNNT.
IPR001978. Troponin.
[Graphical view]
PANTHERiPTHR11521. PTHR11521. 1 hit.
PfamiPF00992. Troponin. 2 hits.
[Graphical view]

Sequences (12)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 12 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: P45379-1) [UniParc]FASTAAdd to basket
Also known as: TNT1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE
60 70 80 90 100
TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI
110 120 130 140 150
HRKRMEKDLN ELQALIEAHF ENRKKEEEEL VSLKDRIERR RAERAEQQRI
160 170 180 190 200
RNEREKERQN RLAEERARRE EEENRRKAED EARKKKALSN MMHFGGYIQK
210 220 230 240 250
QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR EKAKELWQSI
260 270 280 290
YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK
Length:298
Mass (Da):35,924
Last modified:January 23, 2007 - v3
Checksum:i69974F2200CD5BEF
GO
Isoform 2 (identifier: P45379-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: Missing.

Show »
Length:297
Mass (Da):35,794
Checksum:i7A88F02291D9BFFB
GO
Isoform 3 (identifier: P45379-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: Missing.

Show »
Length:297
Mass (Da):35,794
Checksum:iD2B458D8909A0404
GO
Isoform 4 (identifier: P45379-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: Missing.
     54-54: Missing.

Show »
Length:296
Mass (Da):35,665
Checksum:iED0B5849847E101A
GO
Isoform 5 (identifier: P45379-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: Missing.

Show »
Length:297
Mass (Da):35,795
Checksum:iA19DAF593FFCC93C
GO
Isoform 6 (identifier: P45379-6) [UniParc]FASTAAdd to basket
Also known as: TNT3

The sequence of this isoform differs from the canonical sequence as follows:
     23-32: Missing.

Show »
Length:288
Mass (Da):34,590
Checksum:iF7956C33F94255B0
GO
Isoform 7 (identifier: P45379-7) [UniParc]FASTAAdd to basket
Also known as: TNT4

The sequence of this isoform differs from the canonical sequence as follows:
     18-32: Missing.

Show »
Length:283
Mass (Da):34,091
Checksum:iE70D862729679EF5
GO
Isoform 8 (identifier: P45379-8) [UniParc]FASTAAdd to basket
Also known as: TNT2

The sequence of this isoform differs from the canonical sequence as follows:
     18-22: Missing.

Show »
Length:293
Mass (Da):35,424
Checksum:iD2E545EC0C3034DE
GO
Isoform 9 (identifier: P45379-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-137: Missing.

Show »
Length:259
Mass (Da):31,137
Checksum:iA0B999CC0E2005AB
GO
Isoform 10 (identifier: P45379-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-203: Missing.

Show »
Length:295
Mass (Da):35,596
Checksum:i51ADF1E637A72DDC
GO
Isoform 11 (identifier: P45379-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-32: Missing.
     201-203: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):34,263
Checksum:iF0547EE868527B3D
GO
Isoform 12 (identifier: P45379-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: Missing.
     99-137: Missing.
     201-203: Missing.

Show »
Length:255
Mass (Da):30,681
Checksum:iD20694B11931D87A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242K → E in CAA70840 (PubMed:9689598).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06725938A → V in CMH2. 1 PublicationCorresponds to variant rs200754249dbSNPEnsembl.1
Natural variantiVAR_01987780F → L in CMH2. 1 Publication1
Natural variantiVAR_00760589I → N in CMH2. 1 PublicationCorresponds to variant rs121964855dbSNPEnsembl.1
Natural variantiVAR_016195102R → L in CMH2. 1 Publication1
Natural variantiVAR_007606102R → Q in CMH2. 1 PublicationCorresponds to variant rs121964856dbSNPEnsembl.1
Natural variantiVAR_016196102R → W in CMH2. 1 PublicationCorresponds to variant rs397516456dbSNPEnsembl.1
Natural variantiVAR_009194104R → L in CMH2. 1 PublicationCorresponds to variant rs397516457dbSNPEnsembl.1
Natural variantiVAR_016197114A → V in CMH2. 1 PublicationCorresponds to variant rs727504245dbSNPEnsembl.1
Natural variantiVAR_007607120F → I in CMH2. 2 PublicationsCorresponds to variant rs121964858dbSNPEnsembl.1
Natural variantiVAR_019878120F → V in CMH2. 1 Publication1
Natural variantiVAR_013021139R → K.Corresponds to variant rs2996496dbSNPEnsembl.1
Natural variantiVAR_042747140R → C in CMH2. 1 PublicationCorresponds to variant rs397516463dbSNPEnsembl.1
Natural variantiVAR_029450140R → K.Corresponds to variant rs2996496dbSNPEnsembl.1
Natural variantiVAR_043983141R → W in CMD1D. 2 PublicationsCorresponds to variant rs74315380dbSNPEnsembl.1
Natural variantiVAR_016198151R → W in CMD1D. 2 PublicationsCorresponds to variant rs74315379dbSNPEnsembl.1
Natural variantiVAR_007608170Missing in CMH2. 1
Natural variantiVAR_007609173E → K in CMH2. 1 Publication1
Natural variantiVAR_016199189S → F in CMH2. 1 PublicationCorresponds to variant rs727504246dbSNPEnsembl.1
Natural variantiVAR_022931210Missing in CMD1D. 1 Publication1
Natural variantiVAR_043984215R → L in CMD1D. 1 PublicationCorresponds to variant rs121964860dbSNPEnsembl.1
Natural variantiVAR_043985220Missing in CMD1D. 2 Publications1
Natural variantiVAR_042748221I → T.Corresponds to variant rs45520032dbSNPEnsembl.1
Natural variantiVAR_057310231I → T.Corresponds to variant rs45520032dbSNPEnsembl.1
Natural variantiVAR_013022249S → T.Corresponds to variant rs2996495dbSNPEnsembl.1
Natural variantiVAR_007610254E → D in CMH2. 1 PublicationCorresponds to variant rs45466197dbSNPEnsembl.1
Natural variantiVAR_007611263K → R.1 PublicationCorresponds to variant rs3730238dbSNPEnsembl.1
Natural variantiVAR_029451279N → Y.Corresponds to variant rs4523540dbSNPEnsembl.1
Natural variantiVAR_019879281N → I in CMH2. 1 Publication1
Natural variantiVAR_007612288R → C in CMH2. 3 PublicationsCorresponds to variant rs121964857dbSNPEnsembl.1
Natural variantiVAR_007613288R → P in CMH2. 2 PublicationsCorresponds to variant rs397516484dbSNPEnsembl.1
Natural variantiVAR_019880296R → C in CMH2. 1 PublicationCorresponds to variant rs367785431dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00664218 – 32Missing in isoform 7. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_00664118 – 22Missing in isoform 8. 1 Publication5
Alternative sequenceiVSP_00664323 – 32Missing in isoform 6 and isoform 11. 6 Publications10
Alternative sequenceiVSP_00664423Missing in isoform 2 and isoform 4. 1 Publication1
Alternative sequenceiVSP_00664554Missing in isoform 3, isoform 4 and isoform 12. 2 Publications1
Alternative sequenceiVSP_00664699 – 137Missing in isoform 9 and isoform 12. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_006648201 – 203Missing in isoform 10, isoform 11 and isoform 12. 3 Publications3
Alternative sequenceiVSP_006647201Missing in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64668 mRNA. Translation: AAB27731.1. Sequence problems.
X74819 mRNA. Translation: CAA52818.1.
L40162 mRNA. Translation: AAA67422.1.
X79855 mRNA. Translation: CAA56235.1.
X79856 mRNA. Translation: CAA56236.1.
X79857 mRNA. Translation: CAA56237.1.
X79858 mRNA. Translation: CAA56238.1.
AF004422
, AF004409, AF004410, AF004411, AF004412, AF004413, AF004414, AF004415, AF004416, AF004417, AF004418, AF004419, AF004420, AF004421 Genomic DNA. Translation: AAC39590.1.
AY044273 Genomic DNA. Translation: AAK92231.1.
AK290621 mRNA. Translation: BAF83310.1.
EF179183 Genomic DNA. Translation: ABN05286.1.
AC119427 Genomic DNA. No translation available.
BC002653 mRNA. Translation: AAH02653.1.
Y09626 Genomic DNA. Translation: CAA70839.1.
Y09627 Genomic DNA. Translation: CAA70840.1.
Y09628 Genomic DNA. Translation: CAA70841.1.
S71126 mRNA. Translation: AAB30956.1.
S71127, S71128 Genomic DNA. Translation: AAB30957.1.
CCDSiCCDS30968.1. [P45379-11]
CCDS30969.1. [P45379-6]
CCDS60390.1. [P45379-12]
CCDS73003.1. [P45379-1]
PIRiA54671. TPHUTC.
RefSeqiNP_000355.2. NM_000364.3. [P45379-10]
NP_001001430.1. NM_001001430.2. [P45379-6]
NP_001001431.1. NM_001001431.2. [P45379-11]
NP_001001432.1. NM_001001432.2.
NP_001263274.1. NM_001276345.1. [P45379-1]
NP_001263275.1. NM_001276346.1. [P45379-12]
NP_001263276.1. NM_001276347.1. [P45379-6]
XP_006711571.1. XM_006711508.3. [P45379-6]
XP_011508240.1. XM_011509938.2. [P45379-1]
XP_011508241.1. XM_011509939.1. [P45379-3]
XP_011508242.1. XM_011509940.2. [P45379-5]
XP_011508244.1. XM_011509942.2. [P45379-7]
XP_011508245.1. XM_011509943.2. [P45379-7]
XP_016857706.1. XM_017002217.1. [P45379-11]
UniGeneiHs.533613.

Genome annotation databases

EnsembliENST00000236918; ENSP00000236918; ENSG00000118194. [P45379-1]
ENST00000360372; ENSP00000353535; ENSG00000118194. [P45379-12]
ENST00000367318; ENSP00000356287; ENSG00000118194. [P45379-6]
ENST00000367320; ENSP00000356289; ENSG00000118194. [P45379-12]
ENST00000367322; ENSP00000356291; ENSG00000118194. [P45379-11]
ENST00000509001; ENSP00000422031; ENSG00000118194. [P45379-6]
GeneIDi7139.
KEGGihsa:7139.
UCSCiuc001gwg.5. human. [P45379-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64668 mRNA. Translation: AAB27731.1. Sequence problems.
X74819 mRNA. Translation: CAA52818.1.
L40162 mRNA. Translation: AAA67422.1.
X79855 mRNA. Translation: CAA56235.1.
X79856 mRNA. Translation: CAA56236.1.
X79857 mRNA. Translation: CAA56237.1.
X79858 mRNA. Translation: CAA56238.1.
AF004422
, AF004409, AF004410, AF004411, AF004412, AF004413, AF004414, AF004415, AF004416, AF004417, AF004418, AF004419, AF004420, AF004421 Genomic DNA. Translation: AAC39590.1.
AY044273 Genomic DNA. Translation: AAK92231.1.
AK290621 mRNA. Translation: BAF83310.1.
EF179183 Genomic DNA. Translation: ABN05286.1.
AC119427 Genomic DNA. No translation available.
BC002653 mRNA. Translation: AAH02653.1.
Y09626 Genomic DNA. Translation: CAA70839.1.
Y09627 Genomic DNA. Translation: CAA70840.1.
Y09628 Genomic DNA. Translation: CAA70841.1.
S71126 mRNA. Translation: AAB30956.1.
S71127, S71128 Genomic DNA. Translation: AAB30957.1.
CCDSiCCDS30968.1. [P45379-11]
CCDS30969.1. [P45379-6]
CCDS60390.1. [P45379-12]
CCDS73003.1. [P45379-1]
PIRiA54671. TPHUTC.
RefSeqiNP_000355.2. NM_000364.3. [P45379-10]
NP_001001430.1. NM_001001430.2. [P45379-6]
NP_001001431.1. NM_001001431.2. [P45379-11]
NP_001001432.1. NM_001001432.2.
NP_001263274.1. NM_001276345.1. [P45379-1]
NP_001263275.1. NM_001276346.1. [P45379-12]
NP_001263276.1. NM_001276347.1. [P45379-6]
XP_006711571.1. XM_006711508.3. [P45379-6]
XP_011508240.1. XM_011509938.2. [P45379-1]
XP_011508241.1. XM_011509939.1. [P45379-3]
XP_011508242.1. XM_011509940.2. [P45379-5]
XP_011508244.1. XM_011509942.2. [P45379-7]
XP_011508245.1. XM_011509943.2. [P45379-7]
XP_016857706.1. XM_017002217.1. [P45379-11]
UniGeneiHs.533613.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J1DX-ray2.61B/E193-298[»]
1J1EX-ray3.30B/E193-298[»]
4Y99X-ray2.00B193-298[»]
ProteinModelPortaliP45379.
SMRiP45379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112993. 8 interactors.
IntActiP45379. 3 interactors.
MINTiMINT-3015968.
STRINGi9606.ENSP00000356286.

Chemistry databases

ChEMBLiCHEMBL2095202.

PTM databases

iPTMnetiP45379.
PhosphoSitePlusiP45379.

Polymorphism and mutation databases

DMDMi21264536.

2D gel databases

UCD-2DPAGEP45379.

Proteomic databases

PaxDbiP45379.
PeptideAtlasiP45379.
PRIDEiP45379.

Protocols and materials databases

DNASUi7139.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236918; ENSP00000236918; ENSG00000118194. [P45379-1]
ENST00000360372; ENSP00000353535; ENSG00000118194. [P45379-12]
ENST00000367318; ENSP00000356287; ENSG00000118194. [P45379-6]
ENST00000367320; ENSP00000356289; ENSG00000118194. [P45379-12]
ENST00000367322; ENSP00000356291; ENSG00000118194. [P45379-11]
ENST00000509001; ENSP00000422031; ENSG00000118194. [P45379-6]
GeneIDi7139.
KEGGihsa:7139.
UCSCiuc001gwg.5. human. [P45379-1]

Organism-specific databases

CTDi7139.
DisGeNETi7139.
GeneCardsiTNNT2.
GeneReviewsiTNNT2.
HGNCiHGNC:11949. TNNT2.
HPAiCAB015371.
HPA015774.
HPA017888.
MalaCardsiTNNT2.
MIMi115195. phenotype.
191045. gene.
601494. phenotype.
612422. phenotype.
neXtProtiNX_P45379.
OpenTargetsiENSG00000118194.
Orphaneti154. Familial isolated dilated cardiomyopathy.
155. Familial isolated hypertrophic cardiomyopathy.
75249. Familial isolated restrictive cardiomyopathy.
54260. Left ventricular noncompaction.
PharmGKBiPA36638.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3634. Eukaryota.
ENOG410XS6A. LUCA.
GeneTreeiENSGT00390000013611.
HOGENOMiHOG000231049.
HOVERGENiHBG052790.
InParanoidiP45379.
KOiK12045.
OMAiAVCRQQD.
OrthoDBiEOG091G0U67.
PhylomeDBiP45379.
TreeFamiTF313321.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118194-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.
SIGNORiP45379.

Miscellaneous databases

ChiTaRSiTNNT2. human.
EvolutionaryTraceiP45379.
GeneWikiiTNNT2.
GenomeRNAii7139.
PROiP45379.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118194.
CleanExiHS_TNNT2.
ExpressionAtlasiP45379. baseline and differential.
GenevisibleiP45379. HS.

Family and domain databases

InterProiIPR027707. TNNT.
IPR001978. Troponin.
[Graphical view]
PANTHERiPTHR11521. PTHR11521. 1 hit.
PfamiPF00992. Troponin. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNT2_HUMAN
AccessioniPrimary (citable) accession number: P45379
Secondary accession number(s): A2TDB9
, A8K3K6, O60214, Q99596, Q99597, Q9BUF6, Q9UM96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 171 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.