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P45378

- TNNT3_HUMAN

UniProt

P45378 - TNNT3_HUMAN

Protein

Troponin T, fast skeletal muscle

Gene

TNNT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

    GO - Molecular functioni

    1. calcium-dependent protein binding Source: UniProtKB
    2. tropomyosin binding Source: UniProtKB
    3. troponin C binding Source: UniProtKB
    4. troponin I binding Source: UniProtKB

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. muscle filament sliding Source: Reactome
    3. regulation of ATPase activity Source: UniProtKB
    4. regulation of striated muscle contraction Source: UniProtKB
    5. skeletal muscle contraction Source: UniProtKB

    Keywords - Molecular functioni

    Muscle protein

    Enzyme and pathway databases

    ReactomeiREACT_16969. Striated Muscle Contraction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Troponin T, fast skeletal muscle
    Short name:
    TnTf
    Alternative name(s):
    Beta-TnTF
    Fast skeletal muscle troponin T
    Short name:
    fTnT
    Gene namesi
    Name:TNNT3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:11950. TNNT3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. troponin complex Source: UniProtKB

    Pathology & Biotechi

    Involvement in diseasei

    Arthrogryposis, distal, 2B (DA2B) [MIM:601680]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti74 – 741R → H in DA2B. 1 Publication
    VAR_026453

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi601680. phenotype.
    Orphaneti1146. Digitotalar dysmorphism.
    1147. Sheldon-Hall syndrome.
    PharmGKBiPA36639.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 269268Troponin T, fast skeletal musclePRO_0000186178Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei2 – 21Phosphoserine; by CK2By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP45378.
    PRIDEiP45378.

    PTM databases

    PhosphoSiteiP45378.

    Expressioni

    Tissue specificityi

    In fetal and adult fast skeletal muscles, with a higher level expression in fetal than in adult muscle.

    Gene expression databases

    BgeeiP45378.
    GenevestigatoriP45378.

    Organism-specific databases

    HPAiCAB002451.
    HPA037810.

    Interactioni

    Protein-protein interaction databases

    BioGridi112994. 10 interactions.
    IntActiP45378. 6 interactions.
    MINTiMINT-1410650.

    Structurei

    3D structure databases

    ProteinModelPortaliP45378.
    SMRiP45378. Positions 164-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the troponin T family.Curated

    Phylogenomic databases

    eggNOGiNOG299534.
    HOVERGENiHBG052790.
    KOiK12046.
    OMAiAHHEEAH.
    OrthoDBiEOG7W155J.
    PhylomeDBiP45378.
    TreeFamiTF313321.

    Family and domain databases

    InterProiIPR027707. TNNT.
    IPR027708. Tnnt3.
    IPR001978. Troponin.
    [Graphical view]
    PANTHERiPTHR11521. PTHR11521. 1 hit.
    PTHR11521:SF4. PTHR11521:SF4. 1 hit.
    PfamiPF00992. Troponin. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P45378-1) [UniParc]FASTAAdd to Basket

    Also known as: Tnt1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDEEVEQVE EQYEEEEEAQ EEAAEVHEEV HEPEEVQEDT AEEDAEEEKP    50
    RPKLTAPKIP EGEKVDFDDI QKKRQNKDLM ELQALIDSHF EARKKEEEEL 100
    VALKERIEKR RAERAEQQRI RAEKERERQN RLAEEKARRE EEDAKRRAED 150
    DLKKKKALSS MGANYSSYLA KADQKRGKKQ TAREMKKKIL AERRKPLNID 200
    HLGEDKLRDK AKELWETLHQ LEIDKFEFGE KLKRQKYDIT TLRSRIDQAQ 250
    KHSKKAGTPA KGKVGGRWK 269
    Length:269
    Mass (Da):31,825
    Last modified:January 23, 2007 - v3
    Checksum:i87B25AF8773D742F
    GO
    Isoform 2 (identifier: P45378-2) [UniParc]FASTAAdd to Basket

    Also known as: Tnt3

    The sequence of this isoform differs from the canonical sequence as follows:
         23-33: Missing.

    Show »
    Length:258
    Mass (Da):30,596
    Checksum:iF42BF2526BDC5ED9
    GO
    Isoform 3 (identifier: P45378-3) [UniParc]FASTAAdd to Basket

    Also known as: Tnt1f

    The sequence of this isoform differs from the canonical sequence as follows:
         39-46: Missing.

    Show »
    Length:261
    Mass (Da):30,964
    Checksum:i6D7AF5AF58952CD1
    GO
    Isoform 4 (identifier: P45378-4) [UniParc]FASTAAdd to Basket

    Also known as: Tnt3f

    The sequence of this isoform differs from the canonical sequence as follows:
         23-33: Missing.
         39-46: Missing.
         240-252: TTLRSRIDQAQKH → MNVRARVQMLAKF

    Show »
    Length:250
    Mass (Da):29,746
    Checksum:i3E60707FDA580499
    GO
    Isoform 5 (identifier: P45378-5) [UniParc]FASTAAdd to Basket

    Also known as: Tnt3f*

    The sequence of this isoform differs from the canonical sequence as follows:
         23-46: Missing.

    Note: Minor isoform detected in approximately 1% of cDNA clones.

    Show »
    Length:245
    Mass (Da):29,121
    Checksum:i320B367968566805
    GO
    Isoform 6 (identifier: P45378-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         34-46: Missing.

    Show »
    Length:256
    Mass (Da):30,349
    Checksum:i9522A0CA453CB492
    GO
    Isoform 7 (identifier: P45378-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         23-33: Missing.
         39-46: Missing.

    Show »
    Length:250
    Mass (Da):29,735
    Checksum:i9A9651EBDF220547
    GO

    Sequence cautioni

    The sequence AAH50446.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti149 – 1491E → G in CAE45814. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti74 – 741R → H in DA2B. 1 Publication
    VAR_026453

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei23 – 4624Missing in isoform 5. 1 PublicationVSP_009121Add
    BLAST
    Alternative sequencei23 – 3311Missing in isoform 2, isoform 4 and isoform 7. 5 PublicationsVSP_007914Add
    BLAST
    Alternative sequencei34 – 4613Missing in isoform 6. 4 PublicationsVSP_034964Add
    BLAST
    Alternative sequencei39 – 468Missing in isoform 3, isoform 4 and isoform 7. 4 PublicationsVSP_007915
    Alternative sequencei240 – 25213TTLRS…QAQKH → MNVRARVQMLAKF in isoform 4. 2 PublicationsVSP_007916Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21984 mRNA. Translation: AAA36777.1.
    AF026276 Genomic DNA. Translation: AAF21629.1.
    AK056968 mRNA. Translation: BAG51835.1.
    DQ778624 mRNA. Translation: ABG77458.1.
    BX640689 mRNA. Translation: CAE45814.1.
    BT019997 mRNA. Translation: AAV38800.1.
    CR541927 mRNA. Translation: CAG46725.1.
    AC051649 Genomic DNA. No translation available.
    BC050446 mRNA. Translation: AAH50446.1. Different initiation.
    BC117327 mRNA. Translation: AAI17328.1.
    BC171727 mRNA. Translation: AAI71727.1.
    BC143537 mRNA. Translation: AAI43538.1.
    U14641 mRNA. Translation: AAA50359.1.
    U14642 mRNA. Translation: AAA50360.1.
    U14643 mRNA. Translation: AAA50361.1.
    U14644 mRNA. Translation: AAA50362.1.
    CCDSiCCDS41594.1. [P45378-6]
    CCDS41595.1. [P45378-4]
    CCDS41596.1. [P45378-7]
    CCDS7727.1. [P45378-2]
    PIRiI53021.
    S48660.
    S74259.
    S74260.
    S74261.
    RefSeqiNP_001036245.1. NM_001042780.2. [P45378-4]
    NP_001036246.1. NM_001042781.2. [P45378-6]
    NP_001036247.1. NM_001042782.2. [P45378-7]
    NP_006748.1. NM_006757.3. [P45378-2]
    XP_006718353.1. XM_006718290.1. [P45378-1]
    XP_006718356.1. XM_006718293.1. [P45378-3]
    XP_006718363.1. XM_006718300.1. [P45378-5]
    UniGeneiHs.73454.

    Genome annotation databases

    EnsembliENST00000278317; ENSP00000278317; ENSG00000130595. [P45378-2]
    ENST00000344578; ENSP00000344870; ENSG00000130595. [P45378-5]
    ENST00000381558; ENSP00000370970; ENSG00000130595. [P45378-7]
    ENST00000381563; ENSP00000370975; ENSG00000130595. [P45378-3]
    ENST00000381579; ENSP00000370991; ENSG00000130595. [P45378-4]
    ENST00000381589; ENSP00000371001; ENSG00000130595. [P45378-6]
    ENST00000397301; ENSP00000380468; ENSG00000130595. [P45378-1]
    GeneIDi7140.
    KEGGihsa:7140.
    UCSCiuc001luo.4. human. [P45378-4]
    uc001lup.4. human. [P45378-6]
    uc001luq.4. human. [P45378-7]
    uc001luu.4. human. [P45378-2]
    uc010qxg.2. human. [P45378-1]

    Polymorphism databases

    DMDMi33518637.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21984 mRNA. Translation: AAA36777.1 .
    AF026276 Genomic DNA. Translation: AAF21629.1 .
    AK056968 mRNA. Translation: BAG51835.1 .
    DQ778624 mRNA. Translation: ABG77458.1 .
    BX640689 mRNA. Translation: CAE45814.1 .
    BT019997 mRNA. Translation: AAV38800.1 .
    CR541927 mRNA. Translation: CAG46725.1 .
    AC051649 Genomic DNA. No translation available.
    BC050446 mRNA. Translation: AAH50446.1 . Different initiation.
    BC117327 mRNA. Translation: AAI17328.1 .
    BC171727 mRNA. Translation: AAI71727.1 .
    BC143537 mRNA. Translation: AAI43538.1 .
    U14641 mRNA. Translation: AAA50359.1 .
    U14642 mRNA. Translation: AAA50360.1 .
    U14643 mRNA. Translation: AAA50361.1 .
    U14644 mRNA. Translation: AAA50362.1 .
    CCDSi CCDS41594.1. [P45378-6 ]
    CCDS41595.1. [P45378-4 ]
    CCDS41596.1. [P45378-7 ]
    CCDS7727.1. [P45378-2 ]
    PIRi I53021.
    S48660.
    S74259.
    S74260.
    S74261.
    RefSeqi NP_001036245.1. NM_001042780.2. [P45378-4 ]
    NP_001036246.1. NM_001042781.2. [P45378-6 ]
    NP_001036247.1. NM_001042782.2. [P45378-7 ]
    NP_006748.1. NM_006757.3. [P45378-2 ]
    XP_006718353.1. XM_006718290.1. [P45378-1 ]
    XP_006718356.1. XM_006718293.1. [P45378-3 ]
    XP_006718363.1. XM_006718300.1. [P45378-5 ]
    UniGenei Hs.73454.

    3D structure databases

    ProteinModelPortali P45378.
    SMRi P45378. Positions 164-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112994. 10 interactions.
    IntActi P45378. 6 interactions.
    MINTi MINT-1410650.

    PTM databases

    PhosphoSitei P45378.

    Polymorphism databases

    DMDMi 33518637.

    Proteomic databases

    PaxDbi P45378.
    PRIDEi P45378.

    Protocols and materials databases

    DNASUi 7140.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278317 ; ENSP00000278317 ; ENSG00000130595 . [P45378-2 ]
    ENST00000344578 ; ENSP00000344870 ; ENSG00000130595 . [P45378-5 ]
    ENST00000381558 ; ENSP00000370970 ; ENSG00000130595 . [P45378-7 ]
    ENST00000381563 ; ENSP00000370975 ; ENSG00000130595 . [P45378-3 ]
    ENST00000381579 ; ENSP00000370991 ; ENSG00000130595 . [P45378-4 ]
    ENST00000381589 ; ENSP00000371001 ; ENSG00000130595 . [P45378-6 ]
    ENST00000397301 ; ENSP00000380468 ; ENSG00000130595 . [P45378-1 ]
    GeneIDi 7140.
    KEGGi hsa:7140.
    UCSCi uc001luo.4. human. [P45378-4 ]
    uc001lup.4. human. [P45378-6 ]
    uc001luq.4. human. [P45378-7 ]
    uc001luu.4. human. [P45378-2 ]
    uc010qxg.2. human. [P45378-1 ]

    Organism-specific databases

    CTDi 7140.
    GeneCardsi GC11P001940.
    HGNCi HGNC:11950. TNNT3.
    HPAi CAB002451.
    HPA037810.
    MIMi 600692. gene.
    601680. phenotype.
    neXtProti NX_P45378.
    Orphaneti 1146. Digitotalar dysmorphism.
    1147. Sheldon-Hall syndrome.
    PharmGKBi PA36639.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299534.
    HOVERGENi HBG052790.
    KOi K12046.
    OMAi AHHEEAH.
    OrthoDBi EOG7W155J.
    PhylomeDBi P45378.
    TreeFami TF313321.

    Enzyme and pathway databases

    Reactomei REACT_16969. Striated Muscle Contraction.

    Miscellaneous databases

    ChiTaRSi TNNT3. human.
    GeneWikii TNNT3.
    GenomeRNAii 7140.
    NextBioi 27943.
    PROi P45378.
    SOURCEi Search...

    Gene expression databases

    Bgeei P45378.
    Genevestigatori P45378.

    Family and domain databases

    InterProi IPR027707. TNNT.
    IPR027708. Tnnt3.
    IPR001978. Troponin.
    [Graphical view ]
    PANTHERi PTHR11521. PTHR11521. 1 hit.
    PTHR11521:SF4. PTHR11521:SF4. 1 hit.
    Pfami PF00992. Troponin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of human fast skeletal beta troponin T cDNA: comparative sequence analysis of isoforms and insight into the evolution of members of a multigene family."
      Wu Q.-L., Jha P.K., Raychowdhury M.K., Du Y., Leavis P.C., Sarkar S.
      DNA Cell Biol. 13:217-233(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Fetal skeletal muscle.
    2. "Genomic structure of the fast skeletal troponin T gene (TNNT3)."
      Stefancsik R., Mao C., Randall J., Jha P.K., Sarkar S.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
      Tissue: Skeletal muscle.
    4. Li H., Nong W., Zhou G., Ke R., Shen C., Liang M., Tang Z., Huang B., Lin L., Yang S.
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
      Tissue: Liver.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 6 AND 7).
      Tissue: Lung.
    10. "Identification of a fetal exon in the human fast troponin T gene."
      Briggs M.M., Maready M., Schmidt J.M., Schachat F.
      FEBS Lett. 350:37-40(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-67 (ISOFORMS 1; 2; 3; 4 AND 5).
      Tissue: Skeletal muscle.
    11. "Mutations in TNNT3 cause multiple congenital contractures: a second locus for distal arthrogryposis type 2B."
      Sung S.S., Brassington A.-M.E., Krakowiak P.A., Carey J.C., Jorde L.B., Bamshad M.
      Am. J. Hum. Genet. 73:212-214(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT DA2B HIS-74.

    Entry informationi

    Entry nameiTNNT3_HUMAN
    AccessioniPrimary (citable) accession number: P45378
    Secondary accession number(s): A8MQ76
    , A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3