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P45377

- ALD2_MOUSE

UniProt

P45377 - ALD2_MOUSE

Protein

Aldose reductase-related protein 2

Gene

Akr1b8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Alditol + NAD(P)+ = aldose + NAD(P)H.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Proton donor
    Sitei78 – 781Lowers pKa of active site TyrBy similarity
    Binding sitei111 – 1111Substrate

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi211 – 27363NADP1 PublicationAdd
    BLAST

    GO - Molecular functioni

    1. alditol:NADP+ 1-oxidoreductase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    ReactomeiREACT_198569. Retinoid metabolism and transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldose reductase-related protein 2 (EC:1.1.1.21)
    Short name:
    AR
    Alternative name(s):
    Aldehyde reductase
    Fibroblast growth factor-regulated protein
    Protein FR-1
    Gene namesi
    Name:Akr1b8
    Synonyms:Fgfrp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:107673. Akr1b8.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Aldose reductase-related protein 2PRO_0000124631Add
    BLAST

    Proteomic databases

    MaxQBiP45377.
    PaxDbiP45377.
    PRIDEiP45377.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00273096.
    P45377.

    PTM databases

    PhosphoSiteiP45377.

    Expressioni

    Inductioni

    By FGF-1.

    Gene expression databases

    BgeeiP45377.
    GenevestigatoriP45377.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    IntActiP45377. 1 interaction.
    MINTiMINT-4087589.
    STRINGi10090.ENSMUSP00000040244.

    Structurei

    Secondary structure

    1
    316
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 63
    Beta strandi12 – 165
    Helixi25 – 3713
    Beta strandi42 – 443
    Helixi47 – 493
    Helixi52 – 6413
    Helixi70 – 723
    Beta strandi74 – 796
    Helixi81 – 833
    Helixi86 – 10015
    Beta strandi105 – 1106
    Helixi138 – 15013
    Beta strandi153 – 1619
    Helixi164 – 1718
    Beta strandi182 – 1865
    Helixi194 – 2029
    Beta strandi206 – 2116
    Turni228 – 2303
    Helixi232 – 2409
    Helixi245 – 25410
    Turni255 – 2573
    Helixi267 – 2748
    Helixi283 – 2908
    Helixi302 – 3043

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FRBX-ray1.70A2-316[»]
    ProteinModelPortaliP45377.
    SMRiP45377. Positions 2-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP45377.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG0656.
    GeneTreeiENSGT00670000097881.
    HOGENOMiHOG000250272.
    HOVERGENiHBG000020.
    InParanoidiP45377.
    KOiK00011.
    OMAiYAYCNEN.
    OrthoDBiEOG70KGQF.
    PhylomeDBiP45377.
    TreeFamiTF106492.

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000097. AKR. 1 hit.
    PRINTSiPR00069. ALDKETRDTASE.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P45377-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATFVELSTK AKMPIVGLGT WKSPPNQVKE AVKAAIDAGY RHIDCAYAYC    50
    NENEVGEAIQ EKIKEKAVQR EDLFIVSKLW PTCFEKKLLK EAFQKTLTDL 100
    KLDYLDLYLI HWPQGLQPGK ELFPKDDQGR ILTSKTTFLE AWEGMEELVD 150
    QGLVKALGVS NFNHFQIERL LNKPGLKHKP VTNQVECHPY LTQEKLIQYC 200
    HSKGISVTAY SPLGSPDRPS AKPEDPSLLE DPKIKEIAAK HEKTSAQVLI 250
    RFHIQRNVVV IPKSVTPSRI QENIQVFDFQ LSDEEMATIL SFNRNWRACL 300
    LPETVNMEEY PYDAEY 316
    Length:316
    Mass (Da):36,121
    Last modified:January 23, 2007 - v2
    Checksum:i0C6F0A7BA806497C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti242 – 2421E → K in AAH05789. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04204 mRNA. Translation: AAA16953.1.
    BC005789 mRNA. Translation: AAH05789.1.
    CCDSiCCDS19991.1.
    PIRiA53440.
    RefSeqiNP_032038.1. NM_008012.1.
    UniGeneiMm.5378.

    Genome annotation databases

    EnsembliENSMUST00000038406; ENSMUSP00000040244; ENSMUSG00000029762.
    GeneIDi14187.
    KEGGimmu:14187.
    UCSCiuc009bgz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04204 mRNA. Translation: AAA16953.1 .
    BC005789 mRNA. Translation: AAH05789.1 .
    CCDSi CCDS19991.1.
    PIRi A53440.
    RefSeqi NP_032038.1. NM_008012.1.
    UniGenei Mm.5378.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FRB X-ray 1.70 A 2-316 [» ]
    ProteinModelPortali P45377.
    SMRi P45377. Positions 2-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P45377. 1 interaction.
    MINTi MINT-4087589.
    STRINGi 10090.ENSMUSP00000040244.

    PTM databases

    PhosphoSitei P45377.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00273096.
    P45377.

    Proteomic databases

    MaxQBi P45377.
    PaxDbi P45377.
    PRIDEi P45377.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038406 ; ENSMUSP00000040244 ; ENSMUSG00000029762 .
    GeneIDi 14187.
    KEGGi mmu:14187.
    UCSCi uc009bgz.1. mouse.

    Organism-specific databases

    CTDi 14187.
    MGIi MGI:107673. Akr1b8.

    Phylogenomic databases

    eggNOGi COG0656.
    GeneTreei ENSGT00670000097881.
    HOGENOMi HOG000250272.
    HOVERGENi HBG000020.
    InParanoidi P45377.
    KOi K00011.
    OMAi YAYCNEN.
    OrthoDBi EOG70KGQF.
    PhylomeDBi P45377.
    TreeFami TF106492.

    Enzyme and pathway databases

    Reactomei REACT_198569. Retinoid metabolism and transport.

    Miscellaneous databases

    EvolutionaryTracei P45377.
    NextBioi 285402.
    PROi P45377.
    SOURCEi Search...

    Gene expression databases

    Bgeei P45377.
    Genevestigatori P45377.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000097. AKR. 1 hit.
    PRINTSi PR00069. ALDKETRDTASE.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    PROSITEi PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase."
      Donohue P.J., Alberts G.F., Hampton B.S., Winkles J.A.
      J. Biol. Chem. 269:8604-8609(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    3. "1.7-A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor."
      Wilson D.K., Nakano T., Petrash M., Quiocho F.A.
      Biochemistry 34:14323-14330(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH NADPH AND INHIBITOR.

    Entry informationi

    Entry nameiALD2_MOUSE
    AccessioniPrimary (citable) accession number: P45377
    Secondary accession number(s): Q99JN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3