Aldose reductase-related protein 2 - Mus musculus (Mouse)

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P45377 (ALD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Aldose reductase-related protein 2
Short name=AR
EC=1.1.1.21

Alternative name(s):
Aldehyde reductase
Fibroblast growth factor-regulated protein
Protein FR-1

Gene names

Name:	Akr1b8
Synonyms:	Fgfrp

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Alditol + NAD(P)⁺ = aldose + NAD(P)H.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Induction	By FGF-1.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	alditol:NADP+ 1-oxidoreductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 316

315

Aldose reductase-related protein 2

PRO_0000124631

Regions

Nucleotide binding

211 – 273

NADP

Sites

Active site

Proton donor

Binding site

111

Substrate

Site

Lowers pKa of active site Tyr By similarity

Experimental info

Sequence conflict

242

E → K in AAH05789. Ref.2

Secondary structure

316

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P45377 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 0C6F0A7BA806497C
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FASTA

316

36,121

        10         20         30         40         50         60 
MATFVELSTK AKMPIVGLGT WKSPPNQVKE AVKAAIDAGY RHIDCAYAYC NENEVGEAIQ 

        70         80         90        100        110        120 
EKIKEKAVQR EDLFIVSKLW PTCFEKKLLK EAFQKTLTDL KLDYLDLYLI HWPQGLQPGK 

       130        140        150        160        170        180 
ELFPKDDQGR ILTSKTTFLE AWEGMEELVD QGLVKALGVS NFNHFQIERL LNKPGLKHKP 

       190        200        210        220        230        240 
VTNQVECHPY LTQEKLIQYC HSKGISVTAY SPLGSPDRPS AKPEDPSLLE DPKIKEIAAK 

       250        260        270        280        290        300 
HEKTSAQVLI RFHIQRNVVV IPKSVTPSRI QENIQVFDFQ LSDEEMATIL SFNRNWRACL 

       310 
LPETVNMEEY PYDAEY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase." Donohue P.J., Alberts G.F., Hampton B.S., Winkles J.A. J. Biol. Chem. 269:8604-8609(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
[3]	"1.7-A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor." Wilson D.K., Nakano T., Petrash M., Quiocho F.A. Biochemistry 34:14323-14330(1995) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH NADPH AND INHIBITOR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U04204 mRNA. Translation: AAA16953.1.
BC005789 mRNA. Translation: AAH05789.1.

IPI

IPI00273096.

PIR

A53440.

RefSeq

NP_032038.1. NM_008012.1.

UniGene

Mm.5378.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FRB	X-ray	1.70	A	2-316	[»]

ProteinModelPortal

P45377.

SMR

P45377. Positions 2-315.

ModBase

Search...

Protein-protein interaction databases

STRING

10090.ENSMUSP00000040244.

PTM databases

PhosphoSite

P45377.

2D gel databases

REPRODUCTION-2DPAGE

IPI00273096.
P45377.

Proteomic databases

PaxDb

P45377.

PRIDE

P45377.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000038406; ENSMUSP00000040244; ENSMUSG00000029762.

GeneID

14187.

KEGG

mmu:14187.

UCSC

uc009bgz.1. mouse.

Organism-specific databases

CTD

14187.

MGI

MGI:107673. Akr1b8.

Phylogenomic databases

eggNOG

COG0656.

GeneTree

ENSGT00670000097881.

HOGENOM

HOG000250272.

HOVERGEN

HBG000020.

InParanoid

P45377.

K00011.

OMA

WTTHFAP.

OrthoDB

EOG4VMFFR.

Gene expression databases

Bgee

P45377.

Genevestigator

P45377.

GermOnline

ENSMUSG00000029762. Mus musculus.

Family and domain databases

Gene3D

3.20.20.100. 1 hit.

InterPro

IPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]

PANTHER

PTHR11732. PTHR11732. 1 hit.

Pfam

PF00248. Aldo_ket_red. 1 hit.
[Graphical view]

PIRSF

PIRSF000097. AKR. 1 hit.

PRINTS

PR00069. ALDKETRDTASE.

SUPFAM

SSF51430. Aldo/ket_red. 1 hit.

PROSITE

PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P45377.

NextBio

285402.

SOURCE

Search...

Entry information

Entry name

ALD2_MOUSE

Accession

Primary (citable) accession number: P45377
Secondary accession number(s): Q99JN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents