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Protein

Aldose reductase-related protein 2

Gene

Akr1b8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Proton donor1
Sitei78Lowers pKa of active site TyrBy similarity1
Binding sitei111Substrate1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi211 – 273NADP1 PublicationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-MMU-193144. Estrogen biosynthesis.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase-related protein 2 (EC:1.1.1.21)
Short name:
AR
Alternative name(s):
Aldehyde reductase
Fibroblast growth factor-regulated protein
Protein FR-1
Gene namesi
Name:Akr1b8
Synonyms:Fgfrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107673. Akr1b8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001246312 – 316Aldose reductase-related protein 2Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP45377.
MaxQBiP45377.
PaxDbiP45377.
PeptideAtlasiP45377.
PRIDEiP45377.

2D gel databases

REPRODUCTION-2DPAGEIPI00273096.
P45377.

PTM databases

iPTMnetiP45377.
PhosphoSitePlusiP45377.

Expressioni

Inductioni

By FGF-1.

Gene expression databases

BgeeiENSMUSG00000029762.
GenevisibleiP45377. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiP45377. 1 interactor.
MINTiMINT-4087589.
STRINGi10090.ENSMUSP00000040244.

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Beta strandi12 – 16Combined sources5
Helixi25 – 37Combined sources13
Beta strandi42 – 44Combined sources3
Helixi47 – 49Combined sources3
Helixi52 – 64Combined sources13
Helixi70 – 72Combined sources3
Beta strandi74 – 79Combined sources6
Helixi81 – 83Combined sources3
Helixi86 – 100Combined sources15
Beta strandi105 – 110Combined sources6
Helixi138 – 150Combined sources13
Beta strandi153 – 161Combined sources9
Helixi164 – 171Combined sources8
Beta strandi182 – 186Combined sources5
Helixi194 – 202Combined sources9
Beta strandi206 – 211Combined sources6
Turni228 – 230Combined sources3
Helixi232 – 240Combined sources9
Helixi245 – 254Combined sources10
Turni255 – 257Combined sources3
Helixi267 – 274Combined sources8
Helixi283 – 290Combined sources8
Helixi302 – 304Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FRBX-ray1.70A2-316[»]
ProteinModelPortaliP45377.
SMRiP45377.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45377.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
GeneTreeiENSGT00760000119041.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiP45377.
KOiK00011.
OMAiQHEVGEA.
OrthoDBiEOG091G0D69.
PhylomeDBiP45377.
TreeFamiTF106492.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFVELSTK AKMPIVGLGT WKSPPNQVKE AVKAAIDAGY RHIDCAYAYC
60 70 80 90 100
NENEVGEAIQ EKIKEKAVQR EDLFIVSKLW PTCFEKKLLK EAFQKTLTDL
110 120 130 140 150
KLDYLDLYLI HWPQGLQPGK ELFPKDDQGR ILTSKTTFLE AWEGMEELVD
160 170 180 190 200
QGLVKALGVS NFNHFQIERL LNKPGLKHKP VTNQVECHPY LTQEKLIQYC
210 220 230 240 250
HSKGISVTAY SPLGSPDRPS AKPEDPSLLE DPKIKEIAAK HEKTSAQVLI
260 270 280 290 300
RFHIQRNVVV IPKSVTPSRI QENIQVFDFQ LSDEEMATIL SFNRNWRACL
310
LPETVNMEEY PYDAEY
Length:316
Mass (Da):36,121
Last modified:January 23, 2007 - v2
Checksum:i0C6F0A7BA806497C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242E → K in AAH05789 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04204 mRNA. Translation: AAA16953.1.
BC005789 mRNA. Translation: AAH05789.1.
CCDSiCCDS19991.1.
PIRiA53440.
RefSeqiNP_032038.1. NM_008012.1.
UniGeneiMm.5378.

Genome annotation databases

EnsembliENSMUST00000038406; ENSMUSP00000040244; ENSMUSG00000029762.
GeneIDi14187.
KEGGimmu:14187.
UCSCiuc009bgz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04204 mRNA. Translation: AAA16953.1.
BC005789 mRNA. Translation: AAH05789.1.
CCDSiCCDS19991.1.
PIRiA53440.
RefSeqiNP_032038.1. NM_008012.1.
UniGeneiMm.5378.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FRBX-ray1.70A2-316[»]
ProteinModelPortaliP45377.
SMRiP45377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP45377. 1 interactor.
MINTiMINT-4087589.
STRINGi10090.ENSMUSP00000040244.

PTM databases

iPTMnetiP45377.
PhosphoSitePlusiP45377.

2D gel databases

REPRODUCTION-2DPAGEIPI00273096.
P45377.

Proteomic databases

EPDiP45377.
MaxQBiP45377.
PaxDbiP45377.
PeptideAtlasiP45377.
PRIDEiP45377.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038406; ENSMUSP00000040244; ENSMUSG00000029762.
GeneIDi14187.
KEGGimmu:14187.
UCSCiuc009bgz.1. mouse.

Organism-specific databases

CTDi14187.
MGIiMGI:107673. Akr1b8.

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
GeneTreeiENSGT00760000119041.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiP45377.
KOiK00011.
OMAiQHEVGEA.
OrthoDBiEOG091G0D69.
PhylomeDBiP45377.
TreeFamiTF106492.

Enzyme and pathway databases

ReactomeiR-MMU-193144. Estrogen biosynthesis.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

EvolutionaryTraceiP45377.
PROiP45377.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029762.
GenevisibleiP45377. MM.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALD2_MOUSE
AccessioniPrimary (citable) accession number: P45377
Secondary accession number(s): Q99JN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.