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P45377 (ALD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldose reductase-related protein 2

Short name=AR
EC=1.1.1.21
Alternative name(s):
Aldehyde reductase
Fibroblast growth factor-regulated protein
Protein FR-1
Gene names
Name:Akr1b8
Synonyms:Fgfrp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Alditol + NAD(P)+ = aldose + NAD(P)H.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Induction

By FGF-1.

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionalditol:NADP+ 1-oxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Aldose reductase-related protein 2
PRO_0000124631

Regions

Nucleotide binding211 – 27363NADP

Sites

Active site491Proton donor
Binding site1111Substrate
Site781Lowers pKa of active site Tyr By similarity

Experimental info

Sequence conflict2421E → K in AAH05789. Ref.2

Secondary structure

................................................ 316
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P45377 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 0C6F0A7BA806497C

FASTA31636,121
        10         20         30         40         50         60 
MATFVELSTK AKMPIVGLGT WKSPPNQVKE AVKAAIDAGY RHIDCAYAYC NENEVGEAIQ 

        70         80         90        100        110        120 
EKIKEKAVQR EDLFIVSKLW PTCFEKKLLK EAFQKTLTDL KLDYLDLYLI HWPQGLQPGK 

       130        140        150        160        170        180 
ELFPKDDQGR ILTSKTTFLE AWEGMEELVD QGLVKALGVS NFNHFQIERL LNKPGLKHKP 

       190        200        210        220        230        240 
VTNQVECHPY LTQEKLIQYC HSKGISVTAY SPLGSPDRPS AKPEDPSLLE DPKIKEIAAK 

       250        260        270        280        290        300 
HEKTSAQVLI RFHIQRNVVV IPKSVTPSRI QENIQVFDFQ LSDEEMATIL SFNRNWRACL 

       310 
LPETVNMEEY PYDAEY 

« Hide

References

« Hide 'large scale' references
[1]"A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase."
Donohue P.J., Alberts G.F., Hampton B.S., Winkles J.A.
J. Biol. Chem. 269:8604-8609(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
[3]"1.7-A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor."
Wilson D.K., Nakano T., Petrash M., Quiocho F.A.
Biochemistry 34:14323-14330(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH NADPH AND INHIBITOR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U04204 mRNA. Translation: AAA16953.1.
BC005789 mRNA. Translation: AAH05789.1.
PIRA53440.
RefSeqNP_032038.1. NM_008012.1.
UniGeneMm.5378.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FRBX-ray1.70A2-316[»]
ProteinModelPortalP45377.
SMRP45377. Positions 2-315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP45377. 1 interaction.
MINTMINT-4087589.
STRING10090.ENSMUSP00000040244.

PTM databases

PhosphoSiteP45377.

2D gel databases

REPRODUCTION-2DPAGEIPI00273096.
P45377.

Proteomic databases

PaxDbP45377.
PRIDEP45377.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038406; ENSMUSP00000040244; ENSMUSG00000029762.
GeneID14187.
KEGGmmu:14187.
UCSCuc009bgz.1. mouse.

Organism-specific databases

CTD14187.
MGIMGI:107673. Akr1b8.

Phylogenomic databases

eggNOGCOG0656.
GeneTreeENSGT00670000097881.
HOGENOMHOG000250272.
HOVERGENHBG000020.
InParanoidP45377.
KOK00011.
OMAYPFDAEY.
OrthoDBEOG70KGQF.
PhylomeDBP45377.
TreeFamTF106492.

Gene expression databases

BgeeP45377.
GenevestigatorP45377.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFPIRSF000097. AKR. 1 hit.
PRINTSPR00069. ALDKETRDTASE.
SUPFAMSSF51430. SSF51430. 1 hit.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP45377.
NextBio285402.
PROP45377.
SOURCESearch...

Entry information

Entry nameALD2_MOUSE
AccessionPrimary (citable) accession number: P45377
Secondary accession number(s): Q99JN4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot