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P45376

- ALDR_MOUSE

UniProt

P45376 - ALDR_MOUSE

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Protein
Aldose reductase
Gene
Akr1b1, Akr1b3, Aldor1, Aldr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton donor By similarity
Sitei78 – 781Lowers pKa of active site Tyr By similarity
Binding sitei111 – 1111Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 1910NADP Reviewed prediction
Nucleotide bindingi211 – 27363NADP By similarity
Add
BLAST

GO - Molecular functioni

  1. alditol:NADP+ 1-oxidoreductase activity Source: MGI
  2. glyceraldehyde oxidoreductase activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. daunorubicin metabolic process Source: Ensembl
  2. doxorubicin metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_223561. Pregnenolone biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase (EC:1.1.1.21)
Short name:
AR
Alternative name(s):
Aldehyde reductase
Gene namesi
Name:Akr1b1
Synonyms:Akr1b3, Aldor1, Aldr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1353494. Akr1b3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 316315Aldose reductase
PRO_0000124624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei95 – 951N6-acetyllysine By similarity
Modified residuei222 – 2221N6-acetyllysine By similarity
Modified residuei263 – 2631N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP45376.
PaxDbiP45376.
PRIDEiP45376.

2D gel databases

COMPLUYEAST-2DPAGEP45376.
REPRODUCTION-2DPAGEIPI00223757.
P45376.
SWISS-2DPAGEP45376.

PTM databases

PhosphoSiteiP45376.

Expressioni

Tissue specificityi

Abundant in the testis, skeletal muscle and kidney.

Gene expression databases

BgeeiP45376.
GenevestigatoriP45376.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi198069. 2 interactions.
IntActiP45376. 6 interactions.
MINTiMINT-1869603.

Structurei

3D structure databases

ProteinModelPortaliP45376.
SMRiP45376. Positions 2-315.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0656.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiP45376.
KOiK00011.
OMAiDFLDTWT.
OrthoDBiEOG70KGQF.
PhylomeDBiP45376.
TreeFamiTF106492.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45376-1 [UniParc]FASTAAdd to Basket

« Hide

MASHLELNNG TKMPTLGLGT WKSPPGQVTE AVKVAIDLGY RHIDCAQVYQ    50
NEKEVGVALQ EKLKEQVVKR QDLFIVSKLW CTFHDKSMVK GAFQKTLSDL 100
QLDYLDLYLI HWPTGFKPGP DYFPLDASGN VIPSDTDFVD TWTAMEQLVD 150
EGLVKTIGVS NFNPLQIERI LNKPGLKYKP AVNQIECHPY LTQEKLIEYC 200
HSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK YNKTTAQVLI 250
RFPIQRNLVV IPKSVTPVRI AENLKVFDFE VSSEDMATLL SYNRNWRVCA 300
LMSCAKHKDY PFHAEV 316
Length:316
Mass (Da):35,732
Last modified:January 23, 2007 - v3
Checksum:iE18759AD160B4A0E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461A → S in BAA06980. 1 Publication
Sequence conflicti221 – 2211A → G in AAC13358. 1 Publication
Sequence conflicti281 – 2811V → L in AAH04725. 1 Publication
Sequence conflicti281 – 2811V → L in AAH21655. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D32250 mRNA. Translation: BAA06980.1.
L39795 mRNA. Translation: AAA62176.1.
U29152 mRNA. Translation: AAA69958.1.
U89150
, U89140, U89142, U89143, U89144, U89145, U89146, U89147, U89148, U89149 Genomic DNA. Translation: AAC13358.1.
U93231, U93230 Genomic DNA. Translation: AAD32300.1.
AB016665 Genomic DNA. Translation: BAA76413.1.
BC004725 mRNA. Translation: AAH04725.1.
BC021655 mRNA. Translation: AAH21655.1.
CCDSiCCDS19990.1.
PIRiI49484.
RefSeqiNP_033788.3. NM_009658.3.
UniGeneiMm.389126.
Mm.451.

Genome annotation databases

EnsembliENSMUST00000102980; ENSMUSP00000100045; ENSMUSG00000001642.
GeneIDi11677.
KEGGimmu:11677.
UCSCiuc009bgy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D32250 mRNA. Translation: BAA06980.1 .
L39795 mRNA. Translation: AAA62176.1 .
U29152 mRNA. Translation: AAA69958.1 .
U89150
, U89140 , U89142 , U89143 , U89144 , U89145 , U89146 , U89147 , U89148 , U89149 Genomic DNA. Translation: AAC13358.1 .
U93231 , U93230 Genomic DNA. Translation: AAD32300.1 .
AB016665 Genomic DNA. Translation: BAA76413.1 .
BC004725 mRNA. Translation: AAH04725.1 .
BC021655 mRNA. Translation: AAH21655.1 .
CCDSi CCDS19990.1.
PIRi I49484.
RefSeqi NP_033788.3. NM_009658.3.
UniGenei Mm.389126.
Mm.451.

3D structure databases

ProteinModelPortali P45376.
SMRi P45376. Positions 2-315.
ModBasei Search...

Protein-protein interaction databases

BioGridi 198069. 2 interactions.
IntActi P45376. 6 interactions.
MINTi MINT-1869603.

PTM databases

PhosphoSitei P45376.

2D gel databases

COMPLUYEAST-2DPAGE P45376.
REPRODUCTION-2DPAGE IPI00223757.
P45376.
SWISS-2DPAGE P45376.

Proteomic databases

MaxQBi P45376.
PaxDbi P45376.
PRIDEi P45376.

Protocols and materials databases

DNASUi 11677.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102980 ; ENSMUSP00000100045 ; ENSMUSG00000001642 .
GeneIDi 11677.
KEGGi mmu:11677.
UCSCi uc009bgy.2. mouse.

Organism-specific databases

CTDi 11677.
MGIi MGI:1353494. Akr1b3.

Phylogenomic databases

eggNOGi COG0656.
HOGENOMi HOG000250272.
HOVERGENi HBG000020.
InParanoidi P45376.
KOi K00011.
OMAi DFLDTWT.
OrthoDBi EOG70KGQF.
PhylomeDBi P45376.
TreeFami TF106492.

Enzyme and pathway databases

Reactomei REACT_223561. Pregnenolone biosynthesis.

Miscellaneous databases

NextBioi 279311.
PROi P45376.
SOURCEi Search...

Gene expression databases

Bgeei P45376.
Genevestigatori P45376.

Family and domain databases

Gene3Di 3.20.20.100. 1 hit.
InterProi IPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view ]
PANTHERi PTHR11732. PTHR11732. 1 hit.
Pfami PF00248. Aldo_ket_red. 1 hit.
[Graphical view ]
PIRSFi PIRSF000097. AKR. 1 hit.
PRINTSi PR00069. ALDKETRDTASE.
SUPFAMi SSF51430. SSF51430. 1 hit.
PROSITEi PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Presence of a closely related subgroup in the aldo-ketoreductase family of the mouse."
    Gui T., Tanimoto T., Kokai Y., Nishimura C.
    Eur. J. Biochem. 227:448-453(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Kidney.
  2. Iwata T., Carper D.
    Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR X Swiss Webster.
    Tissue: Liver.
  3. Daoudal S., Berger M., Pailhoux E., Tournaire C., Veyssiere G., Jean C.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Kidney.
  4. "Characterization of the mouse aldose reductase gene and promoter in a lens epithelial cell line."
    McGowan M.H., Iwata T., Carper D.A.
    Mol. Vis. 4:2-2(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Ola.
  5. "Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes."
    Ho H.T.B., Jenkins N.A., Copeland N.G., Gilbert D.J., Winkles J.A., Louie H.W.Y., Lee F.K., Chung S.S.M., Chung S.K.
    Eur. J. Biochem. 259:726-730(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  6. "Characterization of genomic regions directing the cell-specific expression of the mouse aldose reductase gene."
    Li H., Nobukuni Y., Gui T., Yabe-Nishimura C.
    Biochem. Biophys. Res. Commun. 255:759-764(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  8. Lubec G., Yang J.W., Zigmond M.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 156-169.
    Tissue: Brain.

Entry informationi

Entry nameiALDR_MOUSE
AccessioniPrimary (citable) accession number: P45376
Secondary accession number(s): O70130, Q99KC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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