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Protein

Aldose reductase

Gene

Akr1b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Proton donorBy similarity1
Sitei78Lowers pKa of active site TyrBy similarity1
Binding sitei111SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 19NADPSequence analysis10
Nucleotide bindingi211 – 273NADPBy similarityAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.1.1.21. 3474.
ReactomeiR-MMU-196108. Pregnenolone biosynthesis.
R-MMU-5652227. Fructose biosynthesis.

Chemistry databases

SwissLipidsiSLP:000001113.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase (EC:1.1.1.21)
Short name:
AR
Alternative name(s):
Aldehyde reductase
Gene namesi
Name:Akr1b1
Synonyms:Akr1b3, Aldor1, Aldr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1353494. Akr1b3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3108653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001246242 – 316Aldose reductaseAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei95N6-acetyllysineBy similarity1
Modified residuei222N6-acetyllysineBy similarity1
Modified residuei263N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP45376.
PaxDbiP45376.
PeptideAtlasiP45376.
PRIDEiP45376.

2D gel databases

COMPLUYEAST-2DPAGEP45376.
REPRODUCTION-2DPAGEIPI00223757.
P45376.
SWISS-2DPAGEP45376.

PTM databases

iPTMnetiP45376.
PhosphoSitePlusiP45376.

Expressioni

Tissue specificityi

Abundant in the testis, skeletal muscle and kidney.

Gene expression databases

BgeeiENSMUSG00000001642.
ExpressionAtlasiP45376. baseline and differential.
GenevisibleiP45376. MM.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi198069. 2 interactors.
IntActiP45376. 6 interactors.
MINTiMINT-1869603.
STRINGi10090.ENSMUSP00000100045.

Structurei

3D structure databases

ProteinModelPortaliP45376.
SMRiP45376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
GeneTreeiENSGT00760000119041.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiP45376.
KOiK00011.
OMAiCALMSCA.
OrthoDBiEOG091G0D69.
PhylomeDBiP45376.
TreeFamiTF106492.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASHLELNNG TKMPTLGLGT WKSPPGQVTE AVKVAIDLGY RHIDCAQVYQ
60 70 80 90 100
NEKEVGVALQ EKLKEQVVKR QDLFIVSKLW CTFHDKSMVK GAFQKTLSDL
110 120 130 140 150
QLDYLDLYLI HWPTGFKPGP DYFPLDASGN VIPSDTDFVD TWTAMEQLVD
160 170 180 190 200
EGLVKTIGVS NFNPLQIERI LNKPGLKYKP AVNQIECHPY LTQEKLIEYC
210 220 230 240 250
HSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK YNKTTAQVLI
260 270 280 290 300
RFPIQRNLVV IPKSVTPVRI AENLKVFDFE VSSEDMATLL SYNRNWRVCA
310
LMSCAKHKDY PFHAEV
Length:316
Mass (Da):35,732
Last modified:January 23, 2007 - v3
Checksum:iE18759AD160B4A0E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46A → S in BAA06980 (PubMed:7851421).Curated1
Sequence conflicti221A → G in AAC13358 (PubMed:9485485).Curated1
Sequence conflicti281V → L in AAH04725 (PubMed:15489334).Curated1
Sequence conflicti281V → L in AAH21655 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32250 mRNA. Translation: BAA06980.1.
L39795 mRNA. Translation: AAA62176.1.
U29152 mRNA. Translation: AAA69958.1.
U89150
, U89140, U89142, U89143, U89144, U89145, U89146, U89147, U89148, U89149 Genomic DNA. Translation: AAC13358.1.
U93231, U93230 Genomic DNA. Translation: AAD32300.1.
AB016665 Genomic DNA. Translation: BAA76413.1.
BC004725 mRNA. Translation: AAH04725.1.
BC021655 mRNA. Translation: AAH21655.1.
CCDSiCCDS19990.1.
PIRiI49484.
RefSeqiNP_033788.3. NM_009658.3.
UniGeneiMm.389126.
Mm.451.

Genome annotation databases

EnsembliENSMUST00000102980; ENSMUSP00000100045; ENSMUSG00000001642.
GeneIDi11677.
KEGGimmu:11677.
UCSCiuc009bgy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32250 mRNA. Translation: BAA06980.1.
L39795 mRNA. Translation: AAA62176.1.
U29152 mRNA. Translation: AAA69958.1.
U89150
, U89140, U89142, U89143, U89144, U89145, U89146, U89147, U89148, U89149 Genomic DNA. Translation: AAC13358.1.
U93231, U93230 Genomic DNA. Translation: AAD32300.1.
AB016665 Genomic DNA. Translation: BAA76413.1.
BC004725 mRNA. Translation: AAH04725.1.
BC021655 mRNA. Translation: AAH21655.1.
CCDSiCCDS19990.1.
PIRiI49484.
RefSeqiNP_033788.3. NM_009658.3.
UniGeneiMm.389126.
Mm.451.

3D structure databases

ProteinModelPortaliP45376.
SMRiP45376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198069. 2 interactors.
IntActiP45376. 6 interactors.
MINTiMINT-1869603.
STRINGi10090.ENSMUSP00000100045.

Chemistry databases

ChEMBLiCHEMBL3108653.
SwissLipidsiSLP:000001113.

PTM databases

iPTMnetiP45376.
PhosphoSitePlusiP45376.

2D gel databases

COMPLUYEAST-2DPAGEP45376.
REPRODUCTION-2DPAGEIPI00223757.
P45376.
SWISS-2DPAGEP45376.

Proteomic databases

EPDiP45376.
PaxDbiP45376.
PeptideAtlasiP45376.
PRIDEiP45376.

Protocols and materials databases

DNASUi11677.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102980; ENSMUSP00000100045; ENSMUSG00000001642.
GeneIDi11677.
KEGGimmu:11677.
UCSCiuc009bgy.2. mouse.

Organism-specific databases

CTDi11677.
MGIiMGI:1353494. Akr1b3.

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
GeneTreeiENSGT00760000119041.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiP45376.
KOiK00011.
OMAiCALMSCA.
OrthoDBiEOG091G0D69.
PhylomeDBiP45376.
TreeFamiTF106492.

Enzyme and pathway databases

BRENDAi1.1.1.21. 3474.
ReactomeiR-MMU-196108. Pregnenolone biosynthesis.
R-MMU-5652227. Fructose biosynthesis.

Miscellaneous databases

PROiP45376.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001642.
ExpressionAtlasiP45376. baseline and differential.
GenevisibleiP45376. MM.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALDR_MOUSE
AccessioniPrimary (citable) accession number: P45376
Secondary accession number(s): O70130, Q99KC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.