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Protein

Aldose reductase

Gene

Akr1b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Proton donorBy similarity1
Sitei78Lowers pKa of active site TyrBy similarity1
Binding sitei111SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 19NADPSequence analysis10
Nucleotide bindingi211 – 273NADPBy similarityAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BRENDAi1.1.1.21 3474
ReactomeiR-MMU-196108 Pregnenolone biosynthesis
R-MMU-5652227 Fructose biosynthesis

Chemistry databases

SwissLipidsiSLP:000001113

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase (EC:1.1.1.21)
Short name:
AR
Alternative name(s):
Aldehyde reductase
Gene namesi
Name:Akr1b1
Synonyms:Akr1b3, Aldor1, Aldr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1353494 Akr1b3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3108653

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001246242 – 316Aldose reductaseAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei95N6-acetyllysineBy similarity1
Modified residuei222N6-acetyllysineBy similarity1
Modified residuei263N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP45376
PaxDbiP45376
PeptideAtlasiP45376
PRIDEiP45376

2D gel databases

COMPLUYEAST-2DPAGEiP45376
REPRODUCTION-2DPAGEiIPI00223757
P45376
SWISS-2DPAGEiP45376

PTM databases

iPTMnetiP45376
PhosphoSitePlusiP45376
SwissPalmiP45376

Expressioni

Tissue specificityi

Abundant in the testis, skeletal muscle and kidney.

Gene expression databases

BgeeiENSMUSG00000001642
ExpressionAtlasiP45376 baseline and differential
GenevisibleiP45376 MM

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi198069, 4 interactors
IntActiP45376, 6 interactors
MINTiP45376
STRINGi10090.ENSMUSP00000100045

Structurei

3D structure databases

ProteinModelPortaliP45376
SMRiP45376
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
GeneTreeiENSGT00760000119041
HOGENOMiHOG000250272
HOVERGENiHBG000020
InParanoidiP45376
KOiK00011
OMAiFNDSSAD
OrthoDBiEOG091G0D69
PhylomeDBiP45376
TreeFamiTF106492

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASHLELNNG TKMPTLGLGT WKSPPGQVTE AVKVAIDLGY RHIDCAQVYQ
60 70 80 90 100
NEKEVGVALQ EKLKEQVVKR QDLFIVSKLW CTFHDKSMVK GAFQKTLSDL
110 120 130 140 150
QLDYLDLYLI HWPTGFKPGP DYFPLDASGN VIPSDTDFVD TWTAMEQLVD
160 170 180 190 200
EGLVKTIGVS NFNPLQIERI LNKPGLKYKP AVNQIECHPY LTQEKLIEYC
210 220 230 240 250
HSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK YNKTTAQVLI
260 270 280 290 300
RFPIQRNLVV IPKSVTPVRI AENLKVFDFE VSSEDMATLL SYNRNWRVCA
310
LMSCAKHKDY PFHAEV
Length:316
Mass (Da):35,732
Last modified:January 23, 2007 - v3
Checksum:iE18759AD160B4A0E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46A → S in BAA06980 (PubMed:7851421).Curated1
Sequence conflicti221A → G in AAC13358 (PubMed:9485485).Curated1
Sequence conflicti281V → L in AAH04725 (PubMed:15489334).Curated1
Sequence conflicti281V → L in AAH21655 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32250 mRNA Translation: BAA06980.1
L39795 mRNA Translation: AAA62176.1
U29152 mRNA Translation: AAA69958.1
U89150
, U89140, U89142, U89143, U89144, U89145, U89146, U89147, U89148, U89149 Genomic DNA Translation: AAC13358.1
U93231, U93230 Genomic DNA Translation: AAD32300.1
AB016665 Genomic DNA Translation: BAA76413.1
BC004725 mRNA Translation: AAH04725.1
BC021655 mRNA Translation: AAH21655.1
CCDSiCCDS19990.1
PIRiI49484
RefSeqiNP_033788.3, NM_009658.3
UniGeneiMm.389126
Mm.451

Genome annotation databases

EnsembliENSMUST00000102980; ENSMUSP00000100045; ENSMUSG00000001642
GeneIDi11677
KEGGimmu:11677
UCSCiuc009bgy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiALDR_MOUSE
AccessioniPrimary (citable) accession number: P45376
Secondary accession number(s): O70130, Q99KC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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