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P45375 (PHBB_ALLVD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetoacetyl-CoA reductase
EC=1.1.1.36
Gene names
Name:phbB
Ordered Locus Names:Alvin_0066
OrganismAllochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum) [Complete proteome] [HAMAP]
Taxonomic identifier572477 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Allochromatium

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH.

Pathway

Biopolymer metabolism; poly-(R)-3-hydroxybutanoate biosynthesis.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Biological processPHB biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpoly-hydroxybutyrate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacetoacetyl-CoA reductase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Acetoacetyl-CoA reductase
PRO_0000054749

Regions

Nucleotide binding7 – 3125NADP By similarity

Sites

Active site1531Proton acceptor By similarity
Binding site1401Substrate By similarity

Experimental info

Sequence conflict2151D → N in AAA23325. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P45375 [UniParc].

Last modified June 15, 2010. Version 2.
Checksum: C7FED7450A1F54E3

FASTA24626,124
        10         20         30         40         50         60 
MARIALVTGG IGGIGTSICT RLAKDGCTVV ANCHPSEAAA AEEWKQARAA EGFDIAVFTA 

        70         80         90        100        110        120 
DVSSFDDSAR MVREITEQVG PIDILVNCAG ITRDKTFKKM EQAHWEAVIN VNLNSVFNVT 

       130        140        150        160        170        180 
RQVWDGMLER GFGRIINISS VNGQRGQFGQ ANYSAAKAGM HGFTMALAQE GASKGVTVNT 

       190        200        210        220        230        240 
ISPGYVETAM TLAMNDDVRN SIISGIPMRR MAQPDEIAAA IAFLAGDESG YMTGANLPVN 


GGLFMH

« Hide

References

« Hide 'large scale' references
[1]"Cloning and nucleotide sequences of genes relevant for biosynthesis of poly(3-hydroxybutyric acid) in Chromatium vinosum strain D."
Liebergesell M., Steinbuechel A.
Eur. J. Biochem. 209:135-150(1992) [PubMed: 1396692] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of chromosome of Allochromatium vinosum DSM 180."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L01112 Genomic DNA. Translation: AAA23325.1.
CP001896 Genomic DNA. Translation: ADC61038.1.
PIRS29279.
RefSeqYP_003442070.1. NC_013851.1.

3D structure databases

ProteinModelPortalP45375.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8785393.
GenomeReviewsGene locus Alvin_0066 in contig CP001896_GR.
KEGGalv:Alvin_0066.
PATRIC31919873. VBIAllVin64954_0068.

Organism-specific databases

CMRSearch...

Phylogenomic databases

ProtClustDBCLSK2806977.

Family and domain databases

InterProIPR011283. Acetoacetyl-CoA_reductase.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00023.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01829. AcAcCoA_reduct. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHBB_ALLVD
AccessionPrimary (citable) accession number: P45375
Secondary accession number(s): D3RUY9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 15, 2010
Last modified: January 25, 2012
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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