SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P45369

- THIL_ALLVD

UniProt

P45369 - THIL_ALLVD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Acetyl-CoA acetyltransferase
Gene
phbA, Alvin_0063
Organism
Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Acyl-thioester intermediate By similarity
Active sitei350 – 3501Proton acceptor By similarity
Active sitei380 – 3801Proton acceptor By similarity

GO - Molecular functioni

  1. acetyl-CoA C-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. poly-hydroxybutyrate biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

PHB biosynthesis

Enzyme and pathway databases

BioCyciAVIN572477:GCJK-63-MONOMER.
UniPathwayiUPA00058; UER00101.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA acetyltransferase (EC:2.3.1.9)
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene namesi
Name:phbA
Ordered Locus Names:Alvin_0063
OrganismiAllochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Taxonomic identifieri572477 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeAllochromatium
ProteomesiUP000001441: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Acetyl-CoA acetyltransferase
PRO_0000206419Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP45369.

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.

Phylogenomic databases

HOGENOMiHOG000012238.
KOiK00626.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45369-1 [UniParc]FASTAAdd to Basket

« Hide

MNENIVIVDA GRSAIGTFSG SLSSLSATEI GTAVLKGLLA RTGLAPEQID    50
EVILGQVLTA GVGQNPARQT TLKAGLPHSV PAMTINKVCG SGLKAVHLAM 100
QAIACGDADI VIAGGQESMS QSSHVLPRSR DGQRMGDWSM KDTMIVDGLW 150
DAFNNYHMGT TAENIAQKYG FTREQQDAFA AASQQKTEAA QKAGRFQDEI 200
IPIEIPQRKG DPKVFDADEF PRHGTTAESL GKLRPAFSRD GSVTAGNASG 250
INDGAAMVVV MKESKAKELG LKPMARLVAF ASAGVDPAIM GTGPIPASTK 300
CLEKAGWTPA DLDLIEANEA FAAQAMSVNQ DMGWDLSKVN VNGGAIAIGH 350
PIGASGARVL VTLLYEMQKR DAKKGLATLC IGGGQGVALA VERM 394
Length:394
Mass (Da):41,129
Last modified:June 15, 2010 - v2
Checksum:i8AECC7EB26B29344
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21N → S in AAA23322. 1 Publication
Sequence conflicti19 – 191S → G in AAA23322. 1 Publication
Sequence conflicti73 – 731K → H in AAA23322. 1 Publication
Sequence conflicti239 – 2391R → K in AAA23322. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01112 Genomic DNA. Translation: AAA23322.1.
CP001896 Genomic DNA. Translation: ADC61035.1.
PIRiS29276.
RefSeqiWP_012969311.1. NC_013851.1.
YP_003442067.1. NC_013851.1.

Genome annotation databases

EnsemblBacteriaiADC61035; ADC61035; Alvin_0063.
GeneIDi8785390.
KEGGialv:Alvin_0063.
PATRICi31919867. VBIAllVin64954_0065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01112 Genomic DNA. Translation: AAA23322.1 .
CP001896 Genomic DNA. Translation: ADC61035.1 .
PIRi S29276.
RefSeqi WP_012969311.1. NC_013851.1.
YP_003442067.1. NC_013851.1.

3D structure databases

ProteinModelPortali P45369.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC61035 ; ADC61035 ; Alvin_0063 .
GeneIDi 8785390.
KEGGi alv:Alvin_0063.
PATRICi 31919867. VBIAllVin64954_0065.

Phylogenomic databases

HOGENOMi HOG000012238.
KOi K00626.

Enzyme and pathway databases

UniPathwayi UPA00058 ; UER00101 .
BioCyci AVIN572477:GCJK-63-MONOMER.

Family and domain databases

Gene3Di 3.40.47.10. 4 hits.
InterProi IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view ]
Pfami PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
TIGRFAMsi TIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEi PS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and nucleotide sequences of genes relevant for biosynthesis of poly(3-hydroxybutyric acid) in Chromatium vinosum strain D."
    Liebergesell M., Steinbuechel A.
    Eur. J. Biochem. 209:135-150(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome of Allochromatium vinosum DSM 180."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.

Entry informationi

Entry nameiTHIL_ALLVD
AccessioniPrimary (citable) accession number: P45369
Secondary accession number(s): D3RUY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 15, 2010
Last modified: September 3, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi