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Reviewed, UniProtKB/Swiss-Prot P45369 (THIL_CHRVI)

Last modified September 22, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Acetyl-CoA acetyltransferase
    EC=2.3.1.9
Alternative name(s):
    Acetoacetyl-CoA thiolase
Gene names
Name: phbA
OrganismChromatium vinosum (Allochromatium vinosum)
Taxonomic identifier1049 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeAllochromatium

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.

Subunit structure

Homotetramer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the thiolase family.

Ontologies

Keywords
   Biological processPHB biosynthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological processpoly-hydroxybutyrate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacetyl-CoA C-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Acetyl-CoA acetyltransferase
PRO_0000206419

Sites

Active site891Acyl-thioester intermediate By similarity
Active site3501Proton acceptor By similarity
Active site3801Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P45369-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 95AC363A270F414A

FASTA39441,053
        10         20         30         40         50         60 
MSENIVIVDA GRSAIGTFGG SLSSLSATEI GTAVLKGLLA RTGLAPEQID EVILGQVLTA 

        70         80         90        100        110        120 
GVGQNPARQT TLHAGLPHSV PAMTINKVCG SGLKAVHLAM QAIACGDADI VIAGGQESMS 

       130        140        150        160        170        180 
QSSHVLPRSR DGQRMGDWSM KDTMIVDGLW DAFNNYHMGT TAENIAQKYG FTREQQDAFA 

       190        200        210        220        230        240 
AASQQKTEAA QKAGRFQDEI IPIEIPQRKG DPKVFDADEF PRHGTTAESL GKLRPAFSKD 

       250        260        270        280        290        300 
GSVTAGNASG INDGAAMVVV MKESKAKELG LKPMARLVAF ASAGVDPAIM GTGPIPASTK 

       310        320        330        340        350        360 
CLEKAGWTPA DLDLIEANEA FAAQAMSVNQ DMGWDLSKVN VNGGAIAIGH PIGASGARVL 

       370        380        390 
VTLLYEMQKR DAKKGLATLC IGGGQGVALA VERM 

« Hide

References

[1]"Cloning and nucleotide sequences of genes relevant for biosynthesis of poly(3-hydroxybutyric acid) in Chromatium vinosum strain D."
Liebergesell M., Steinbuechel A.
Eur. J. Biochem. 209:135-150(1992) [PubMed: 1396692] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 17899 / DSM 180 / D.

Cross-references

Sequence databases

L01112 Genomic DNA. Translation: AAA23322.1.
PIRS29276.

3D structure databases

HSSPHSSP built from PDB template 1M4T based on UniProtKB P07097.
ModBaseSearch...

Enzyme and pathway databases

BRENDA2.3.1.9. 2799.

Family and domain databases

InterProIPR002155. Thiolase.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 1 hit.
PANTHERPTHR18919. Thiolase. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHIL_CHRVI
AccessionPrimary (citable) accession number: P45369
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 22, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents