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P45363

- THIL_THIVI

UniProt

P45363 - THIL_THIVI

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Protein

Acetyl-CoA acetyltransferase

Gene
phbA
Organism
Thiocystis violacea
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Acyl-thioester intermediate By similarity
Active sitei350 – 3501Proton acceptor By similarity
Active sitei380 – 3801Proton acceptor By similarity

GO - Molecular functioni

  1. acetyl-CoA C-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. poly-hydroxybutyrate biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

PHB biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00058; UER00101.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA acetyltransferase (EC:2.3.1.9)
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene namesi
Name:phbA
OrganismiThiocystis violacea
Taxonomic identifieri13725 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeThiocystis

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Acetyl-CoA acetyltransferasePRO_0000206462Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP45363.
SMRiP45363. Positions 4-394.

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45363-1 [UniParc]FASTAAdd to Basket

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MSDTIVIVDA GRTAIGTFGG ALSALQATDI GTTVLKALIE RTGIAPEQVS    50
EVILGQVLTA GCGQNPARQT TLMAGLPHTV PAMTINKVCG SGLKAVHLAM 100
QAVACGDAEI VIAGGQESMS QSSHVLPRSR EGQRMGDWPM KDTMIVDGLW 150
DAFNQCHMGV TAENIAKKYA FTREAQDAFA AASQQKAEAA IQSGRFADEI 200
IPVSIPQRKG DPLVFDTDEF PRPGTTAETL GRLRPAFDKQ GTVTAGNASG 250
INDGAAMVVV MKESKAKELG LTPMARLVAF SSAGVDPAIM GTGPIPASTD 300
CLKKAGWAPA DLDLVEANEA FAAQAMSVNQ EMGWDLSKVN VNGGAIAIGH 350
PIGASGARVL VTLLYEMQKR DAKKGLATLC IGGGQGVALA VERL 394
Length:394
Mass (Da):40,897
Last modified:November 1, 1995 - v1
Checksum:iD51EAAE97F55E3F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01113 Genomic DNA. Translation: AAB02860.1.
S54369 Genomic DNA. Translation: AAC60428.2.
PIRiB48376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01113 Genomic DNA. Translation: AAB02860.1 .
S54369 Genomic DNA. Translation: AAC60428.2 .
PIRi B48376.

3D structure databases

ProteinModelPortali P45363.
SMRi P45363. Positions 4-394.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00058 ; UER00101 .

Family and domain databases

Gene3Di 3.40.47.10. 4 hits.
InterProi IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view ]
Pfami PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
TIGRFAMsi TIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEi PS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and molecular analysis of the poly(3-hydroxybutyric acid) biosynthetic genes of Thiocystis violacea."
    Liebergesell M., Steinbuechel A.
    Appl. Microbiol. Biotechnol. 38:493-501(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 2311 / DSM 208.

Entry informationi

Entry nameiTHIL_THIVI
AccessioniPrimary (citable) accession number: P45363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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