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P45363

- THIL_THIVI

UniProt

P45363 - THIL_THIVI

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Protein

Acetyl-CoA acetyltransferase

Gene

phbA

Organism
Thiocystis violacea
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Acyl-thioester intermediateBy similarity
Active sitei350 – 3501Proton acceptorPROSITE-ProRule annotation
Active sitei380 – 3801Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. acetyl-CoA C-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. poly-hydroxybutyrate biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

PHB biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00058; UER00101.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA acetyltransferase (EC:2.3.1.9)
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene namesi
Name:phbA
OrganismiThiocystis violacea
Taxonomic identifieri13725 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeThiocystis

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Acetyl-CoA acetyltransferasePRO_0000206462Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP45363.
SMRiP45363. Positions 4-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45363-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDTIVIVDA GRTAIGTFGG ALSALQATDI GTTVLKALIE RTGIAPEQVS
60 70 80 90 100
EVILGQVLTA GCGQNPARQT TLMAGLPHTV PAMTINKVCG SGLKAVHLAM
110 120 130 140 150
QAVACGDAEI VIAGGQESMS QSSHVLPRSR EGQRMGDWPM KDTMIVDGLW
160 170 180 190 200
DAFNQCHMGV TAENIAKKYA FTREAQDAFA AASQQKAEAA IQSGRFADEI
210 220 230 240 250
IPVSIPQRKG DPLVFDTDEF PRPGTTAETL GRLRPAFDKQ GTVTAGNASG
260 270 280 290 300
INDGAAMVVV MKESKAKELG LTPMARLVAF SSAGVDPAIM GTGPIPASTD
310 320 330 340 350
CLKKAGWAPA DLDLVEANEA FAAQAMSVNQ EMGWDLSKVN VNGGAIAIGH
360 370 380 390
PIGASGARVL VTLLYEMQKR DAKKGLATLC IGGGQGVALA VERL
Length:394
Mass (Da):40,897
Last modified:November 1, 1995 - v1
Checksum:iD51EAAE97F55E3F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01113 Genomic DNA. Translation: AAB02860.1.
S54369 Genomic DNA. Translation: AAC60428.2.
PIRiB48376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01113 Genomic DNA. Translation: AAB02860.1 .
S54369 Genomic DNA. Translation: AAC60428.2 .
PIRi B48376.

3D structure databases

ProteinModelPortali P45363.
SMRi P45363. Positions 4-394.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00058 ; UER00101 .

Family and domain databases

Gene3Di 3.40.47.10. 4 hits.
InterProi IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view ]
Pfami PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
TIGRFAMsi TIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEi PS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and molecular analysis of the poly(3-hydroxybutyric acid) biosynthetic genes of Thiocystis violacea."
    Liebergesell M., Steinbuechel A.
    Appl. Microbiol. Biotechnol. 38:493-501(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 2311 / DSM 208.

Entry informationi

Entry nameiTHIL_THIVI
AccessioniPrimary (citable) accession number: P45363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3