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P45363 (THIL_THIVI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetyl-CoA acetyltransferase

EC=2.3.1.9
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene names
Name:phbA
OrganismThiocystis violacea
Taxonomic identifier13725 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeThiocystis

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the thiolase family.

Ontologies

Keywords
   Biological processPHB biosynthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processpoly-hydroxybutyrate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacetyl-CoA C-acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Acetyl-CoA acetyltransferase
PRO_0000206462

Sites

Active site891Acyl-thioester intermediate By similarity
Active site3501Proton acceptor By similarity
Active site3801Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P45363 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D51EAAE97F55E3F2

FASTA39440,897
        10         20         30         40         50         60 
MSDTIVIVDA GRTAIGTFGG ALSALQATDI GTTVLKALIE RTGIAPEQVS EVILGQVLTA 

        70         80         90        100        110        120 
GCGQNPARQT TLMAGLPHTV PAMTINKVCG SGLKAVHLAM QAVACGDAEI VIAGGQESMS 

       130        140        150        160        170        180 
QSSHVLPRSR EGQRMGDWPM KDTMIVDGLW DAFNQCHMGV TAENIAKKYA FTREAQDAFA 

       190        200        210        220        230        240 
AASQQKAEAA IQSGRFADEI IPVSIPQRKG DPLVFDTDEF PRPGTTAETL GRLRPAFDKQ 

       250        260        270        280        290        300 
GTVTAGNASG INDGAAMVVV MKESKAKELG LTPMARLVAF SSAGVDPAIM GTGPIPASTD 

       310        320        330        340        350        360 
CLKKAGWAPA DLDLVEANEA FAAQAMSVNQ EMGWDLSKVN VNGGAIAIGH PIGASGARVL 

       370        380        390 
VTLLYEMQKR DAKKGLATLC IGGGQGVALA VERL 

« Hide

References

[1]"Cloning and molecular analysis of the poly(3-hydroxybutyric acid) biosynthetic genes of Thiocystis violacea."
Liebergesell M., Steinbuechel A.
Appl. Microbiol. Biotechnol. 38:493-501(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 2311 / DSM 208.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L01113 Genomic DNA. Translation: AAB02860.1.
S54369 Genomic DNA. Translation: AAC60428.2.
PIRB48376.

3D structure databases

ProteinModelPortalP45363.
SMRP45363. Positions 4-394.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00058; UER00101.

Family and domain databases

Gene3D3.40.47.10. 4 hits.
InterProIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PANTHERPTHR18919. PTHR18919. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHIL_THIVI
AccessionPrimary (citable) accession number: P45363
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways