Reviewed, UniProtKB/Swiss-Prot P45358 (HIS8_ACEPA)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Synonyms:	his1

Organism

Acetobacter pasteurianus (Acetobacter turbidans)

Taxonomic identifier

438 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acetobacter

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_0000153290
Amino acid modifications
	Modified residue	210	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45358-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 8926199C5242DF51	FASTA	356	39,136
	10 20 30 40 50 60 MSRFWSPLVH KLTPYVPGEQ PKMTDLIKLN TNESPYGPSP RALEAIRAAD NDTLRLYPDP 70 80 90 100 110 120 EALALRKALG ARIGLGPEYV FVGNGSDEVL AHAFQAFFAH GEPLLFPDVT YSFYKVYCGL 130 140 150 160 170 180 YSLPFRNVPL TDDMQVNVAD YAGPCSGVVV ANPNAPTGIA LDLADVRKLL ELQPNRVVLI 190 200 210 220 230 240 DEAYVDFGAE SAVSLIKEYP NLLVVQTFSK SRALAGLRVG FAFGQPELIE GLVRIKDSFN 250 260 270 280 290 300 SYPLDRLAQV GATAAVEDEA WLATSVQKVM ASRTVLTEGL QKLGFDVLPS KANFVYTRHP 310 320 330 340 350 NRNAAELATQ LRERAIIVRH LRGERTAAWL RITVGTDQQC ETLLSALRDI LCSNSL

References

[1]	"Suppression of an ethanol-sensitive mutation of Acetobacter pasteurianus by overexpression of the his1 gene encoding histidinol phosphate aminotransferase." Takemura H., Horinouchi S., Beppu T. J. Ferment. Bioeng. 76:224-228(1993) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NCI 1452.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D14440 Genomic DNA. Translation: BAA03332.1.
PIR	I39488.
3D structure databases
HSSP	HSSP built from PDB template 1GEW based on UniProtKB P06986.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.6.1.9. 66798.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_ACEPA

Accession

Primary (citable) accession number: P45358

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	September 22, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)