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P45331 (METE_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:HI_1702
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length756 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7567565-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_0000098633

Sites

Metal binding6421Zinc By similarity
Metal binding6441Zinc By similarity
Metal binding7271Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P45331 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: FD48C9033E51BDE8

FASTA75685,239
        10         20         30         40         50         60 
MTTSHILGFP RVGAKRELKF AQERYWRKEL AEQDLLDLAK ALREKNWKHQ AAANADFVAV 

        70         80         90        100        110        120 
GDFTFYDHIL DLQVATGAIP ARFGFDSQNL TLDQYFQLAR GNKDQFAIEM TKWFDTNYHY 

       130        140        150        160        170        180 
LVPEFQKSTA FKANPAHYVN QIREAKALGL NFKPVIVGPL TFLWLGKEKG EAFNRFDLLN 

       190        200        210        220        230        240 
QLVPVYVEIL NALVAEGAEW IQIDEPALAL DLPAEWVEAY KSVYTELSKV NAKLLLATYF 

       250        260        270        280        290        300 
GSVAEHAELL KALPVAGLHL DLVRAPEQLA AFEDYSKVLS AGVIEGRNIW RANLNKVLDV 

       310        320        330        340        350        360 
LEPLKAKLGE RLWIAPSCSL LHTPFDLEVE VQLKEKNTAL YSWLSFTLQK VEELNVLKQA 

       370        380        390        400        410        420 
LNNGRASVQA ALDASQVAAD ARATSKEIHR PEVAERLANL PKGADQRKSP FAERIVKQNA 

       430        440        450        460        470        480 
WLNLPLLPTT NIGSFPQTTE IRHARASFKK GELSLADYEA AMKKEIEYVV RRQEELDLDV 

       490        500        510        520        530        540 
LVHGEAERND MVEYFGELLD GFAFTKFGWV QSYGSRCVKP PVIYGDVTRP EPMTVRWSQY 

       550        560        570        580        590        600 
AQSLTNRVMK GMLTGPVTIL QWSFVRNDIP RSTVCKQIGV ALSDEVLDLE AAGIKVIQID 

       610        620        630        640        650        660 
EPAIREGLPL KRADWDAYLQ WAGEAFRLSS MGVQDDTQIH THMCYSEFND ILPAIAALDA 

       670        680        690        700        710        720 
DVITIETSRS DMELLTAFAD FKYPNDIGPG VYDIHSPRVP TATEVEHLLR KALNVIPKER 

       730        740        750 
LWVNPDCGLK TRGWTETIDQ LKVMVDVTKK LRAELA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC23348.1.
PIRB64137.
RefSeqNP_439844.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45331.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID949942.
GenomeReviewsGene locus HI_1702 in contig L42023_GR.
KEGGhin:HI1702.
NMPDRfig|71421.1.peg.1615.
PATRIC20192155. VBIHaeInf48452_1781.
TIGRHI_1702.

Phylogenomic databases

HOGENOMHBG287495.
OMARNIWRAN.
PhylomeDBP45331.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycHINF71421:HI_1702-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_HAEIN
AccessionPrimary (citable) accession number: P45331
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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