ID   SOHB_HAEIN              Reviewed;         353 AA.
AC   P45315;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   27-MAR-2024, entry version 117.
DE   RecName: Full=Probable protease SohB;
DE            EC=3.4.21.-;
GN   Name=sohB; OrderedLocusNames=HI_1682;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Possible protease. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S49 family. {ECO:0000305}.
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DR   EMBL; L42023; AAC23328.1; -; Genomic_DNA.
DR   PIR; D64136; D64136.
DR   RefSeq; NP_439824.1; NC_000907.1.
DR   AlphaFoldDB; P45315; -.
DR   SMR; P45315; -.
DR   STRING; 71421.HI_1682; -.
DR   EnsemblBacteria; AAC23328; AAC23328; HI_1682.
DR   KEGG; hin:HI_1682; -.
DR   PATRIC; fig|71421.8.peg.1761; -.
DR   eggNOG; COG0616; Bacteria.
DR   HOGENOM; CLU_070316_0_0_6; -.
DR   OrthoDB; 5614232at2; -.
DR   PhylomeDB; P45315; -.
DR   BioCyc; HINF71421:G1GJ1-1698-MONOMER; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd07023; S49_Sppa_N_C; 1.
DR   Gene3D; 6.20.330.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR002142; Peptidase_S49.
DR   InterPro; IPR013703; Peptidase_S49_N_proteobac.
DR   InterPro; IPR047272; S49_SppA_C.
DR   PANTHER; PTHR42987; PEPTIDASE S49; 1.
DR   PANTHER; PTHR42987:SF1; PROTEASE SOHB-RELATED; 1.
DR   Pfam; PF01343; Peptidase_S49; 1.
DR   Pfam; PF08496; Peptidase_S49_N; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Reference proteome;
KW   Serine protease; Transmembrane; Transmembrane helix.
FT   CHAIN           1..353
FT                   /note="Probable protease SohB"
FT                   /id="PRO_0000171449"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          70..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        181
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        233
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   353 AA;  39872 MW;  4C2E6D75B0F88070 CRC64;
     MLNDILTGYG IFILEILTIL LLILAVVGLI ISYRQHNKSK VGELEIKDLS EEFNEQVRLL
     RDFNLSEEEQ KQRTKAEKKA EKQNAKKRKE KLKKGETLED EKKACVYVLD FCGDISASET
     TALREEISAI LNVAKSEDEV LLRLESPGGI VHNYGFAASQ LSRLKQKGIK LTVAVDKVAA
     SGGYMMACVA DKIVSAPFAV IGSIGVVAQI PNVHRLLKKH DVDVDVMTAG EFKRTVTVLG
     ENTEKGKQKF QQELEETHKL FKQFVSQNRP CLDIDKIATG EHWFGQQAIA LQLVDEISTS
     DDLILEKMKE KQVLNVKYRL KKSLIKKFGR QAEESAINII HRYSTKQSRD FMY
//