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Protein

Probable protease SohB

Gene

sohB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Possible protease.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei181 – 1811NucleophileBy similarity
Active sitei233 – 2331Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS49.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protease SohB (EC:3.4.21.-)
Gene namesi
Name:sohB
Ordered Locus Names:HI_1682
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Probable protease SohBPRO_0000171449Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1682.

Structurei

3D structure databases

ProteinModelPortaliP45315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S49 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0616.
KOiK04774.
OMAiMMACIGE.
OrthoDBiEOG6P5ZHQ.
PhylomeDBiP45315.

Family and domain databases

Gene3Di3.90.226.10. 2 hits.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR002142. Peptidase_S49.
IPR013703. Peptidase_S49_N_proteobac.
[Graphical view]
PfamiPF01343. Peptidase_S49. 1 hit.
PF08496. Peptidase_S49_N. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.

Sequencei

Sequence statusi: Complete.

P45315-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNDILTGYG IFILEILTIL LLILAVVGLI ISYRQHNKSK VGELEIKDLS
60 70 80 90 100
EEFNEQVRLL RDFNLSEEEQ KQRTKAEKKA EKQNAKKRKE KLKKGETLED
110 120 130 140 150
EKKACVYVLD FCGDISASET TALREEISAI LNVAKSEDEV LLRLESPGGI
160 170 180 190 200
VHNYGFAASQ LSRLKQKGIK LTVAVDKVAA SGGYMMACVA DKIVSAPFAV
210 220 230 240 250
IGSIGVVAQI PNVHRLLKKH DVDVDVMTAG EFKRTVTVLG ENTEKGKQKF
260 270 280 290 300
QQELEETHKL FKQFVSQNRP CLDIDKIATG EHWFGQQAIA LQLVDEISTS
310 320 330 340 350
DDLILEKMKE KQVLNVKYRL KKSLIKKFGR QAEESAINII HRYSTKQSRD

FMY
Length:353
Mass (Da):39,872
Last modified:November 1, 1995 - v1
Checksum:i4C2E6D75B0F88070
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23328.1.
PIRiD64136.
RefSeqiNP_439824.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23328; AAC23328; HI_1682.
GeneIDi950509.
KEGGihin:HI1682.
PATRICi20192115. VBIHaeInf48452_1761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23328.1.
PIRiD64136.
RefSeqiNP_439824.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP45315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1682.

Protein family/group databases

MEROPSiS49.002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23328; AAC23328; HI_1682.
GeneIDi950509.
KEGGihin:HI1682.
PATRICi20192115. VBIHaeInf48452_1761.

Phylogenomic databases

eggNOGiCOG0616.
KOiK04774.
OMAiMMACIGE.
OrthoDBiEOG6P5ZHQ.
PhylomeDBiP45315.

Family and domain databases

Gene3Di3.90.226.10. 2 hits.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR002142. Peptidase_S49.
IPR013703. Peptidase_S49_N_proteobac.
[Graphical view]
PfamiPF01343. Peptidase_S49. 1 hit.
PF08496. Peptidase_S49_N. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiSOHB_HAEIN
AccessioniPrimary (citable) accession number: P45315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.