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P45311 (MOAA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cyclic pyranopterin monophosphate synthase

EC=4.1.99.18
Alternative name(s):
Molybdenum cofactor biosynthesis protein A
Gene names
Name:moaA
Ordered Locus Names:HI_1676
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) By similarity. HAMAP-Rule MF_01225

Catalytic activity

GTP = cyclic pyranopterin phosphate + diphosphate. HAMAP-Rule MF_01225

Cofactor

Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate By similarity.

Binds 1 S-adenosyl-L-methionine per subunit By similarity.

Pathway

Cofactor biosynthesis; molybdopterin biosynthesis. HAMAP-Rule MF_01225

Subunit structure

Monomer and homodimer By similarity. HAMAP-Rule MF_01225

Sequence similarities

Belongs to the radical SAM superfamily. MoaA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Cyclic pyranopterin monophosphate synthase HAMAP-Rule MF_01225
PRO_0000152966

Regions

Region270 – 2723GTP binding By similarity

Sites

Metal binding331Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Metal binding371Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Metal binding401Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Metal binding2651Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal binding2681Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal binding2821Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Binding site261GTP By similarity
Binding site391S-adenosyl-L-methionine By similarity
Binding site761GTP By similarity
Binding site801S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site1071GTP By similarity
Binding site1311S-adenosyl-L-methionine By similarity
Binding site1681GTP By similarity
Binding site2021S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P45311 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 1D47939FBBB2D0DE

FASTA33738,305
        10         20         30         40         50         60 
MQSIPIKNVG ESRLVDPFQR QYYYLRLSIT DQCNFRCTYC LPDGYQPEAN KPSFLTLKEI 

        70         80         90        100        110        120 
THLAQAFAEM GTEKIRLTGG EPTLRKDFIS IAESITNIDG IRQLAVTTNG YRMAKDVADW 

       130        140        150        160        170        180 
KKAGITSINV SVDSLDPKMF HQITGINKFD DVMRGIDRAF EVGYNKVKVN SVLMKNLNDK 

       190        200        210        220        230        240 
EFEQFLAWVK DRPIQMRFIE LMQTGEMDSF FDKFHLSGQV LADKLLKNGW TLQHKSHTDG 

       250        260        270        280        290        300 
PAKVFTHPDY AGEIGLIMPY EKNFCASCNR LRVSAKGKLH LCLFGEEGIE LRDLLQSHEQ 

       310        320        330 
QGILQARIFA ALQGKREHHY LHIGDTGVRN HLASIGG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23321.1.
PIRB64136.
RefSeqNP_439818.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1676.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23321; AAC23321; HI_1676.
GeneID950505.
KEGGhin:HI1676.
PATRIC20192103. VBIHaeInf48452_1755.

Phylogenomic databases

eggNOGCOG2896.
KOK03639.
OMAMFHQITG.
OrthoDBEOG64XXNN.
ProtClustDBPRK00164.

Enzyme and pathway databases

UniPathwayUPA00344.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01225_B. MoaA_B.
InterProIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR013483. MoaA.
IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
IPR010505. Mob_synth_C.
IPR007197. rSAM.
[Graphical view]
PfamPF06463. Mob_synth_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsTIGR02666. moaA. 1 hit.
PROSITEPS01305. MOAA_NIFB_PQQE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMOAA_HAEIN
AccessionPrimary (citable) accession number: P45311
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names