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P45311

- MOAA_HAEIN

UniProt

P45311 - MOAA_HAEIN

Protein

Cyclic pyranopterin monophosphate synthase

Gene

moaA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z).UniRule annotation

    Catalytic activityi

    GTP = cyclic pyranopterin phosphate + diphosphate.UniRule annotation

    Cofactori

    Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate.UniRule annotation
    Binds 1 S-adenosyl-L-methionine per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei26 – 261GTPUniRule annotation
    Metal bindingi33 – 331Iron-sulfur 1 (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi37 – 371Iron-sulfur 1 (4Fe-4S-S-AdoMet)UniRule annotation
    Binding sitei39 – 391S-adenosyl-L-methionineUniRule annotation
    Metal bindingi40 – 401Iron-sulfur 1 (4Fe-4S-S-AdoMet)UniRule annotation
    Binding sitei76 – 761GTPUniRule annotation
    Binding sitei80 – 801S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei107 – 1071GTPUniRule annotation
    Binding sitei131 – 1311S-adenosyl-L-methionineUniRule annotation
    Binding sitei168 – 1681GTPUniRule annotation
    Binding sitei202 – 2021S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenUniRule annotation
    Metal bindingi265 – 2651Iron-sulfur 2 (4Fe-4S-substrate)UniRule annotation
    Metal bindingi268 – 2681Iron-sulfur 2 (4Fe-4S-substrate)UniRule annotation
    Metal bindingi282 – 2821Iron-sulfur 2 (4Fe-4S-substrate)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. cyclic pyranopterin monophosphate synthase activity Source: UniProtKB-EC
    3. GTP binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Molybdenum cofactor biosynthesis

    Keywords - Ligandi

    4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00344.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic pyranopterin monophosphate synthaseUniRule annotation (EC:4.1.99.18UniRule annotation)
    Alternative name(s):
    Molybdenum cofactor biosynthesis protein AUniRule annotation
    Gene namesi
    Name:moaAUniRule annotation
    Ordered Locus Names:HI_1676
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. molybdopterin synthase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Cyclic pyranopterin monophosphate synthasePRO_0000152966Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer and homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi71421.HI1676.

    Structurei

    3D structure databases

    ProteinModelPortaliP45311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni270 – 2723GTP bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the radical SAM superfamily. MoaA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2896.
    KOiK03639.
    OMAiMFHQITG.
    OrthoDBiEOG64XXNN.
    PhylomeDBiP45311.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01225_B. MoaA_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR013483. MoaA.
    IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
    IPR010505. Mob_synth_C.
    IPR007197. rSAM.
    [Graphical view]
    PfamiPF06463. Mob_synth_C. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02666. moaA. 1 hit.
    PROSITEiPS01305. MOAA_NIFB_PQQE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P45311-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSIPIKNVG ESRLVDPFQR QYYYLRLSIT DQCNFRCTYC LPDGYQPEAN    50
    KPSFLTLKEI THLAQAFAEM GTEKIRLTGG EPTLRKDFIS IAESITNIDG 100
    IRQLAVTTNG YRMAKDVADW KKAGITSINV SVDSLDPKMF HQITGINKFD 150
    DVMRGIDRAF EVGYNKVKVN SVLMKNLNDK EFEQFLAWVK DRPIQMRFIE 200
    LMQTGEMDSF FDKFHLSGQV LADKLLKNGW TLQHKSHTDG PAKVFTHPDY 250
    AGEIGLIMPY EKNFCASCNR LRVSAKGKLH LCLFGEEGIE LRDLLQSHEQ 300
    QGILQARIFA ALQGKREHHY LHIGDTGVRN HLASIGG 337
    Length:337
    Mass (Da):38,305
    Last modified:November 1, 1995 - v1
    Checksum:i1D47939FBBB2D0DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23321.1.
    PIRiB64136.
    RefSeqiNP_439818.1. NC_000907.1.
    WP_005694398.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC23321; AAC23321; HI_1676.
    GeneIDi950505.
    KEGGihin:HI1676.
    PATRICi20192103. VBIHaeInf48452_1755.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23321.1 .
    PIRi B64136.
    RefSeqi NP_439818.1. NC_000907.1.
    WP_005694398.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P45311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1676.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC23321 ; AAC23321 ; HI_1676 .
    GeneIDi 950505.
    KEGGi hin:HI1676.
    PATRICi 20192103. VBIHaeInf48452_1755.

    Phylogenomic databases

    eggNOGi COG2896.
    KOi K03639.
    OMAi MFHQITG.
    OrthoDBi EOG64XXNN.
    PhylomeDBi P45311.

    Enzyme and pathway databases

    UniPathwayi UPA00344 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01225_B. MoaA_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR013483. MoaA.
    IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
    IPR010505. Mob_synth_C.
    IPR007197. rSAM.
    [Graphical view ]
    Pfami PF06463. Mob_synth_C. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02666. moaA. 1 hit.
    PROSITEi PS01305. MOAA_NIFB_PQQE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiMOAA_HAEIN
    AccessioniPrimary (citable) accession number: P45311
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3