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P45311

- MOAA_HAEIN

UniProt

P45311 - MOAA_HAEIN

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Protein
Cyclic pyranopterin monophosphate synthase
Gene
moaA, HI_1676
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) By similarity.UniRule annotation

Catalytic activityi

GTP = cyclic pyranopterin phosphate + diphosphate.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate By similarity.
Binds 1 S-adenosyl-L-methionine per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei26 – 261GTP By similarity
Metal bindingi33 – 331Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi37 – 371Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Binding sitei39 – 391S-adenosyl-L-methionine By similarity
Metal bindingi40 – 401Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Binding sitei76 – 761GTP By similarity
Binding sitei80 – 801S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei107 – 1071GTP By similarity
Binding sitei131 – 1311S-adenosyl-L-methionine By similarity
Binding sitei168 – 1681GTP By similarity
Binding sitei202 – 2021S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen By similarity
Metal bindingi265 – 2651Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal bindingi268 – 2681Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal bindingi282 – 2821Iron-sulfur 2 (4Fe-4S-substrate) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. cyclic pyranopterin monophosphate synthase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Keywords - Ligandi

4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00344.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic pyranopterin monophosphate synthase (EC:4.1.99.18)
Alternative name(s):
Molybdenum cofactor biosynthesis protein A
Gene namesi
Name:moaA
Ordered Locus Names:HI_1676
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. molybdopterin synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Cyclic pyranopterin monophosphate synthaseUniRule annotation
PRO_0000152966Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI1676.

Structurei

3D structure databases

ProteinModelPortaliP45311.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni270 – 2723GTP binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2896.
KOiK03639.
OMAiMFHQITG.
OrthoDBiEOG64XXNN.
PhylomeDBiP45311.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01225_B. MoaA_B.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR013483. MoaA.
IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
IPR010505. Mob_synth_C.
IPR007197. rSAM.
[Graphical view]
PfamiPF06463. Mob_synth_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02666. moaA. 1 hit.
PROSITEiPS01305. MOAA_NIFB_PQQE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45311-1 [UniParc]FASTAAdd to Basket

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MQSIPIKNVG ESRLVDPFQR QYYYLRLSIT DQCNFRCTYC LPDGYQPEAN    50
KPSFLTLKEI THLAQAFAEM GTEKIRLTGG EPTLRKDFIS IAESITNIDG 100
IRQLAVTTNG YRMAKDVADW KKAGITSINV SVDSLDPKMF HQITGINKFD 150
DVMRGIDRAF EVGYNKVKVN SVLMKNLNDK EFEQFLAWVK DRPIQMRFIE 200
LMQTGEMDSF FDKFHLSGQV LADKLLKNGW TLQHKSHTDG PAKVFTHPDY 250
AGEIGLIMPY EKNFCASCNR LRVSAKGKLH LCLFGEEGIE LRDLLQSHEQ 300
QGILQARIFA ALQGKREHHY LHIGDTGVRN HLASIGG 337
Length:337
Mass (Da):38,305
Last modified:November 1, 1995 - v1
Checksum:i1D47939FBBB2D0DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23321.1.
PIRiB64136.
RefSeqiNP_439818.1. NC_000907.1.
WP_005694398.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23321; AAC23321; HI_1676.
GeneIDi950505.
KEGGihin:HI1676.
PATRICi20192103. VBIHaeInf48452_1755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23321.1 .
PIRi B64136.
RefSeqi NP_439818.1. NC_000907.1.
WP_005694398.1. NC_000907.1.

3D structure databases

ProteinModelPortali P45311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1676.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23321 ; AAC23321 ; HI_1676 .
GeneIDi 950505.
KEGGi hin:HI1676.
PATRICi 20192103. VBIHaeInf48452_1755.

Phylogenomic databases

eggNOGi COG2896.
KOi K03639.
OMAi MFHQITG.
OrthoDBi EOG64XXNN.
PhylomeDBi P45311.

Enzyme and pathway databases

UniPathwayi UPA00344 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01225_B. MoaA_B.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR013483. MoaA.
IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
IPR010505. Mob_synth_C.
IPR007197. rSAM.
[Graphical view ]
Pfami PF06463. Mob_synth_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02666. moaA. 1 hit.
PROSITEi PS01305. MOAA_NIFB_PQQE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiMOAA_HAEIN
AccessioniPrimary (citable) accession number: P45311
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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