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Protein

Molybdopterin synthase sulfur carrier subunit

Gene

moaD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin.By similarity

Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Keywords - Ligandi

Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00344.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdopterin synthase sulfur carrier subunit
Alternative name(s):
MPT synthase subunit 1
Molybdenum cofactor biosynthesis protein D
Molybdopterin-converting factor small subunit
Molybdopterin-converting factor subunit 1
Sulfur carrier protein MoaD
Gene namesi
Name:moaD
Ordered Locus Names:HI_1674
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002091321 – 81Molybdopterin synthase sulfur carrier subunitAdd BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei811-thioglycine; alternateBy similarity1
Modified residuei81Glycyl adenylate; alternateBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Forms a stable heterotetrameric complex of 2 MoaD and 2 MoeB during adenylation of MoaD by MoeB. During catalysis MoaD shuttles between the two heterotetrameric complexes (By similarity).By similarity

Protein-protein interaction databases

STRINGi71421.HI1674.

Structurei

3D structure databases

ProteinModelPortaliP45309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MoaD family.Curated

Phylogenomic databases

eggNOGiENOG4105M00. Bacteria.
COG1977. LUCA.
KOiK03636.
OMAiRELVACD.
PhylomeDBiP45309.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR012675. Beta-grasp_dom.
IPR010034. Mopterin_su_1.
IPR016155. Mopterin_synth/thiamin_S_b.
IPR003749. ThiS/MoaD.
[Graphical view]
PfamiPF02597. ThiS. 1 hit.
[Graphical view]
SUPFAMiSSF54285. SSF54285. 1 hit.
TIGRFAMsiTIGR01682. moaD. 1 hit.

Sequencei

Sequence statusi: Complete.

P45309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNVLFFAQT RELIGVDAIQ LEDDFATAEA VREHLAQKGD KWALALEKGK
60 70 80
LLVAINQTLM PLESAVKNGD EIAFFPPVTG G
Length:81
Mass (Da):8,826
Last modified:November 1, 1997 - v2
Checksum:i35D1440F82456F22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23319.1.
PIRiA59368.
RefSeqiNP_439816.1. NC_000907.1.
WP_005654167.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23319; AAC23319; HI_1674.
GeneIDi950503.
KEGGihin:HI1674.
PATRICi20192099. VBIHaeInf48452_1753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23319.1.
PIRiA59368.
RefSeqiNP_439816.1. NC_000907.1.
WP_005654167.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP45309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1674.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23319; AAC23319; HI_1674.
GeneIDi950503.
KEGGihin:HI1674.
PATRICi20192099. VBIHaeInf48452_1753.

Phylogenomic databases

eggNOGiENOG4105M00. Bacteria.
COG1977. LUCA.
KOiK03636.
OMAiRELVACD.
PhylomeDBiP45309.

Enzyme and pathway databases

UniPathwayiUPA00344.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR012675. Beta-grasp_dom.
IPR010034. Mopterin_su_1.
IPR016155. Mopterin_synth/thiamin_S_b.
IPR003749. ThiS/MoaD.
[Graphical view]
PfamiPF02597. ThiS. 1 hit.
[Graphical view]
SUPFAMiSSF54285. SSF54285. 1 hit.
TIGRFAMsiTIGR01682. moaD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOAD_HAEIN
AccessioniPrimary (citable) accession number: P45309
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.