P45309 (MOAD_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Molybdopterin synthase sulfur carrier subunit

Alternative name(s):
MPT synthase subunit 1
Molybdenum cofactor biosynthesis protein D
Molybdopterin-converting factor small subunit
Molybdopterin-converting factor subunit 1
Sulfur carrier protein MoaD

Gene names

Name:	moaD
Ordered Locus Names:	HI_1674

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	81 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin By similarity.
Pathway	Cofactor biosynthesis; molybdopterin biosynthesis.
Subunit structure	Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Forms a stable heterotetrameric complex of 2 MoaD and 2 MoeB during adenylation of MoaD by MoeB. During catalysis MoaD shuttles between the two heterotetrameric complexes By similarity.
Sequence similarities	Belongs to the MoaD family.

Ontologies

Keywords
Biological process	Molybdenum cofactor biosynthesis
Ligand	Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Mo-molybdopterin cofactor biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 81	81	Molybdopterin synthase sulfur carrier subunit		PRO_0000209132
Amino acid modifications
	Modified residue	81	1	1-thioglycine; alternate By similarity
	Modified residue	81	1	Glycyl adenylate; alternate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45309 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 35D1440F82456F22	FASTA	81	8,826
	10 20 30 40 50 60 MLNVLFFAQT RELIGVDAIQ LEDDFATAEA VREHLAQKGD KWALALEKGK LLVAINQTLM 70 80 PLESAVKNGD EIAFFPPVTG G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC23319.1.
PIR	A59368.
RefSeq	NP_439816.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P45309.
SMR	P45309. Positions 1-81.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI1674.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC23319; AAC23319; HI_1674.
GeneID	950503.
KEGG	hin:HI1674.
PATRIC	20192099. VBIHaeInf48452_1753.
Phylogenomic databases
eggNOG	COG1977.
KO	K03636.
OMA	AEQNLMC.
ProtClustDB	PRK11130.
Enzyme and pathway databases
UniPathway	UPA00344.
Family and domain databases
Gene3D	3.10.20.30. 1 hit.
InterPro	IPR012675. Beta-grasp_dom. IPR010034. Mopterin_su_1. IPR016155. Mopterin_synth/thiamin_S_b. IPR003749. ThiS/MoaD. [Graphical view]
Pfam	PF02597. ThiS. 1 hit. [Graphical view]
SUPFAM	SSF54285. Mo_synth/thiamin_syn_S_b-grasp. 1 hit.
TIGRFAMs	TIGR01682. moaD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MOAD_HAEIN

Accession

Primary (citable) accession number: P45309

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program