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P45303

- ODO1_HAEIN

UniProt

P45303 - ODO1_HAEIN

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
sucA, HI_1662
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:HI_1662
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9359352-oxoglutarate dehydrogenase E1 component
PRO_0000162194Add
BLAST

Proteomic databases

PRIDEiP45303.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi71421.HI1662.

Structurei

3D structure databases

ProteinModelPortaliP45303.
SMRiP45303. Positions 88-934.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.
PhylomeDBiP45303.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

P45303-1 [UniParc]FASTAAdd to Basket

« Hide

MQQNKAFDDW LASTALGGAN QSYIEELYES YLSDPQSVEE SWRKTFDSLP    50
KTTALEQPHT PVRDYFRRLA RENHNEAVTV IDPAAGAKLV KVLQFINAYR 100
FRGHLEANLD PLNYYRWKVS FVPELDYRHH GFTEQDLNET FNINHYVYKR 150
DTIKLGELAQ MLKETYCGSI GLEFMHVQDM EQKMWLQSKM ESLLDKPLFT 200
SEERVNFLRE LTAADGLERY LGAKFPGAKR FSLEGSDAFI PLMKEIIRHS 250
SRQGVNDVVM GMAHRGRLNM LVNVLGKKPE NLFDEFAGKH SSERTGDVKY 300
HQGFSSDFAV DDKRVHLTLA FNPSHLEIVS PVVIGSVRSR QTRMNDTEHS 350
KVLAITVHGD SAVAGQGVVQ ETLNMSNTRG YSVGGTIRIV INNQIGFTTS 400
NPNDTRSTEY CTDIAKMIQA PIIHVNGDDP EAVAFAARMA VEYRNLFKRD 450
IFIDLISYRR HGHNEADEPL ATQPMMYSII KKHPTPRKVY ADRLVSEGVM 500
TEEQVTEMAN DYRDALDNGD RVVSEWREMD TAKMDWLQYL NYDWTAPYES 550
KFSQERFLTL AKRVCEYPES LRAHPRVEKI YNDRKAMYQG EKLLDWGMAE 600
TMAYATLLDE GVNVRLSGED AGRGTFFHRH AVVHNQNDGT GYVPLTHLHA 650
NQGRFEVWDS VLSEESVLAF EYGYATTDPK TLTIWEAQFG DFANGAQIVI 700
DQFISSGEQK WGRMCGLVML LPHGYEGQGP EHSSARLERY LQLCAEQNMQ 750
VCVPSTPAQV YHMLRRQSLR KMRRPLIAIS PKSLLRHPLA VSSLDELING 800
TFQTVIGEID ELDPKDVKRV VMCSGKVYYD LLEQRRANNQ KDVAIIRIEQ 850
LYPFPHEDVK KALEPYAHVT DYVWCQEEPL NQGAWYCSKH NFESAIPESV 900
KLKYAGRPAS ASPAVGYMSL HTKQQKQLVE DALSF 935
Length:935
Mass (Da):106,806
Last modified:November 1, 1995 - v1
Checksum:i33607F3C3AFDDC78
GO

Sequence cautioni

The sequence AAC23308.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23308.1. Different initiation.
PIRiE64135.
RefSeqiNP_439804.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23308; AAC23308; HI_1662.
GeneIDi950496.
KEGGihin:HI1662.
PATRICi20192073. VBIHaeInf48452_1740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23308.1 . Different initiation.
PIRi E64135.
RefSeqi NP_439804.2. NC_000907.1.

3D structure databases

ProteinModelPortali P45303.
SMRi P45303. Positions 88-934.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1662.

Proteomic databases

PRIDEi P45303.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23308 ; AAC23308 ; HI_1662 .
GeneIDi 950496.
KEGGi hin:HI1662.
PATRICi 20192073. VBIHaeInf48452_1740.

Phylogenomic databases

eggNOGi COG0567.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.
PhylomeDBi P45303.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiODO1_HAEIN
AccessioniPrimary (citable) accession number: P45303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi