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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:HI_1662
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9359352-oxoglutarate dehydrogenase E1 componentPRO_0000162194Add
BLAST

Proteomic databases

PRIDEiP45303.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1662.

Structurei

3D structure databases

ProteinModelPortaliP45303.
SMRiP45303. Positions 88-934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.
PhylomeDBiP45303.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

P45303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQNKAFDDW LASTALGGAN QSYIEELYES YLSDPQSVEE SWRKTFDSLP
60 70 80 90 100
KTTALEQPHT PVRDYFRRLA RENHNEAVTV IDPAAGAKLV KVLQFINAYR
110 120 130 140 150
FRGHLEANLD PLNYYRWKVS FVPELDYRHH GFTEQDLNET FNINHYVYKR
160 170 180 190 200
DTIKLGELAQ MLKETYCGSI GLEFMHVQDM EQKMWLQSKM ESLLDKPLFT
210 220 230 240 250
SEERVNFLRE LTAADGLERY LGAKFPGAKR FSLEGSDAFI PLMKEIIRHS
260 270 280 290 300
SRQGVNDVVM GMAHRGRLNM LVNVLGKKPE NLFDEFAGKH SSERTGDVKY
310 320 330 340 350
HQGFSSDFAV DDKRVHLTLA FNPSHLEIVS PVVIGSVRSR QTRMNDTEHS
360 370 380 390 400
KVLAITVHGD SAVAGQGVVQ ETLNMSNTRG YSVGGTIRIV INNQIGFTTS
410 420 430 440 450
NPNDTRSTEY CTDIAKMIQA PIIHVNGDDP EAVAFAARMA VEYRNLFKRD
460 470 480 490 500
IFIDLISYRR HGHNEADEPL ATQPMMYSII KKHPTPRKVY ADRLVSEGVM
510 520 530 540 550
TEEQVTEMAN DYRDALDNGD RVVSEWREMD TAKMDWLQYL NYDWTAPYES
560 570 580 590 600
KFSQERFLTL AKRVCEYPES LRAHPRVEKI YNDRKAMYQG EKLLDWGMAE
610 620 630 640 650
TMAYATLLDE GVNVRLSGED AGRGTFFHRH AVVHNQNDGT GYVPLTHLHA
660 670 680 690 700
NQGRFEVWDS VLSEESVLAF EYGYATTDPK TLTIWEAQFG DFANGAQIVI
710 720 730 740 750
DQFISSGEQK WGRMCGLVML LPHGYEGQGP EHSSARLERY LQLCAEQNMQ
760 770 780 790 800
VCVPSTPAQV YHMLRRQSLR KMRRPLIAIS PKSLLRHPLA VSSLDELING
810 820 830 840 850
TFQTVIGEID ELDPKDVKRV VMCSGKVYYD LLEQRRANNQ KDVAIIRIEQ
860 870 880 890 900
LYPFPHEDVK KALEPYAHVT DYVWCQEEPL NQGAWYCSKH NFESAIPESV
910 920 930
KLKYAGRPAS ASPAVGYMSL HTKQQKQLVE DALSF
Length:935
Mass (Da):106,806
Last modified:November 1, 1995 - v1
Checksum:i33607F3C3AFDDC78
GO

Sequence cautioni

The sequence AAC23308.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23308.1. Different initiation.
PIRiE64135.
RefSeqiNP_439804.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23308; AAC23308; HI_1662.
GeneIDi950496.
KEGGihin:HI1662.
PATRICi20192073. VBIHaeInf48452_1740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23308.1. Different initiation.
PIRiE64135.
RefSeqiNP_439804.2. NC_000907.1.

3D structure databases

ProteinModelPortaliP45303.
SMRiP45303. Positions 88-934.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1662.

Proteomic databases

PRIDEiP45303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23308; AAC23308; HI_1662.
GeneIDi950496.
KEGGihin:HI1662.
PATRICi20192073. VBIHaeInf48452_1740.

Phylogenomic databases

eggNOGiCOG0567.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.
PhylomeDBiP45303.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiODO1_HAEIN
AccessioniPrimary (citable) accession number: P45303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.