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P45303 (ODO1_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:sucA
Ordered Locus Names:HI_1662
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length935 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Sequence caution

The sequence AAC23308.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9359352-oxoglutarate dehydrogenase E1 component
PRO_0000162194

Sequences

Sequence LengthMass (Da)Tools
P45303 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 33607F3C3AFDDC78

FASTA935106,806
        10         20         30         40         50         60 
MQQNKAFDDW LASTALGGAN QSYIEELYES YLSDPQSVEE SWRKTFDSLP KTTALEQPHT 

        70         80         90        100        110        120 
PVRDYFRRLA RENHNEAVTV IDPAAGAKLV KVLQFINAYR FRGHLEANLD PLNYYRWKVS 

       130        140        150        160        170        180 
FVPELDYRHH GFTEQDLNET FNINHYVYKR DTIKLGELAQ MLKETYCGSI GLEFMHVQDM 

       190        200        210        220        230        240 
EQKMWLQSKM ESLLDKPLFT SEERVNFLRE LTAADGLERY LGAKFPGAKR FSLEGSDAFI 

       250        260        270        280        290        300 
PLMKEIIRHS SRQGVNDVVM GMAHRGRLNM LVNVLGKKPE NLFDEFAGKH SSERTGDVKY 

       310        320        330        340        350        360 
HQGFSSDFAV DDKRVHLTLA FNPSHLEIVS PVVIGSVRSR QTRMNDTEHS KVLAITVHGD 

       370        380        390        400        410        420 
SAVAGQGVVQ ETLNMSNTRG YSVGGTIRIV INNQIGFTTS NPNDTRSTEY CTDIAKMIQA 

       430        440        450        460        470        480 
PIIHVNGDDP EAVAFAARMA VEYRNLFKRD IFIDLISYRR HGHNEADEPL ATQPMMYSII 

       490        500        510        520        530        540 
KKHPTPRKVY ADRLVSEGVM TEEQVTEMAN DYRDALDNGD RVVSEWREMD TAKMDWLQYL 

       550        560        570        580        590        600 
NYDWTAPYES KFSQERFLTL AKRVCEYPES LRAHPRVEKI YNDRKAMYQG EKLLDWGMAE 

       610        620        630        640        650        660 
TMAYATLLDE GVNVRLSGED AGRGTFFHRH AVVHNQNDGT GYVPLTHLHA NQGRFEVWDS 

       670        680        690        700        710        720 
VLSEESVLAF EYGYATTDPK TLTIWEAQFG DFANGAQIVI DQFISSGEQK WGRMCGLVML 

       730        740        750        760        770        780 
LPHGYEGQGP EHSSARLERY LQLCAEQNMQ VCVPSTPAQV YHMLRRQSLR KMRRPLIAIS 

       790        800        810        820        830        840 
PKSLLRHPLA VSSLDELING TFQTVIGEID ELDPKDVKRV VMCSGKVYYD LLEQRRANNQ 

       850        860        870        880        890        900 
KDVAIIRIEQ LYPFPHEDVK KALEPYAHVT DYVWCQEEPL NQGAWYCSKH NFESAIPESV 

       910        920        930 
KLKYAGRPAS ASPAVGYMSL HTKQQKQLVE DALSF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23308.1. Different initiation.
PIRE64135.
RefSeqNP_439804.2. NC_000907.1.

3D structure databases

ProteinModelPortalP45303.
SMRP45303. Positions 88-934.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1662.

Proteomic databases

PRIDEP45303.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23308; AAC23308; HI_1662.
GeneID950496.
KEGGhin:HI1662.
PATRIC20192073. VBIHaeInf48452_1740.

Phylogenomic databases

eggNOGCOG0567.
KOK00164.
OMAGHQNANL.
OrthoDBEOG6V1M1F.
PhylomeDBP45303.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_HAEIN
AccessionPrimary (citable) accession number: P45303
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names