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Protein

Penicillin-binding protein activator LpoA

Gene

lpoA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell shape, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein activator LpoA
Short name:
PBP activator LpoA
Gene namesi
Name:lpoA
Ordered Locus Names:HI_1655
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000016945326 – 575Penicillin-binding protein activator LpoAAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi26N-palmitoyl cysteineSequence analysis1
Lipidationi26S-diacylglycerol cysteineSequence analysis1
Disulfide bondi356 ↔ 5541 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts with PBP1a.By similarity

Protein-protein interaction databases

STRINGi71421.HI1655.

Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 39Combined sources6
Helixi46 – 51Combined sources6
Helixi53 – 55Combined sources3
Helixi59 – 75Combined sources17
Helixi79 – 87Combined sources9
Helixi94 – 110Combined sources17
Helixi114 – 122Combined sources9
Helixi126 – 128Combined sources3
Helixi131 – 147Combined sources17
Helixi151 – 164Combined sources14
Helixi168 – 184Combined sources17
Helixi187 – 192Combined sources6
Helixi199 – 214Combined sources16
Helixi218 – 231Combined sources14
Helixi236 – 239Combined sources4
Helixi243 – 247Combined sources5
Beta strandi259 – 263Combined sources5
Helixi270 – 284Combined sources15
Beta strandi291 – 295Combined sources5
Turni296 – 298Combined sources3
Helixi301 – 310Combined sources10
Beta strandi315 – 317Combined sources3
Helixi322 – 330Combined sources9
Helixi332 – 335Combined sources4
Beta strandi339 – 343Combined sources5
Beta strandi355 – 357Combined sources3
Helixi362 – 375Combined sources14
Beta strandi382 – 388Combined sources7
Helixi389 – 406Combined sources18
Beta strandi411 – 417Combined sources7
Helixi420 – 427Combined sources8
Beta strandi434 – 437Combined sources4
Helixi441 – 451Combined sources11
Turni452 – 454Combined sources3
Beta strandi459 – 462Combined sources4
Helixi464 – 466Combined sources3
Helixi469 – 472Combined sources4
Helixi475 – 480Combined sources6
Turni481 – 483Combined sources3
Beta strandi485 – 488Combined sources4
Helixi490 – 493Combined sources4
Helixi498 – 506Combined sources9
Turni507 – 509Combined sources3
Helixi511 – 528Combined sources18
Helixi530 – 535Combined sources6
Beta strandi541 – 543Combined sources3
Beta strandi546 – 550Combined sources5
Beta strandi555 – 559Combined sources5
Beta strandi561 – 566Combined sources6
Beta strandi569 – 572Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CKMX-ray1.35A256-573[»]
4P29X-ray1.95A/B33-253[»]
ProteinModelPortaliP45299.
SMRiP45299.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45299.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpoA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105E1C. Bacteria.
COG3107. LUCA.
KOiK07121.
OMAiFCETPWL.
PhylomeDBiP45299.

Family and domain databases

HAMAPiMF_01890. LpoA. 1 hit.
InterProiIPR007443. LpoA.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF04348. LppC. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILLQGERF KKRLMPILLS MALAGCSNLL GSNFTQTLQK DANASSEFYI
60 70 80 90 100
NKLGQTQELE DQQTYKLLAA RVLIRENKVE QSAALLRELG ELNDAQKLDR
110 120 130 140 150
ALIEARISAA KNANEVAQNQ LRALDLNKLS PSQKSRYYET LAIVAENRKD
160 170 180 190 200
MIEAVKARIE MDKNLTDVQR HQDNIDKTWA LLRSANTGVI NNASDEGNAA
210 220 230 240 250
LGGWLTLIKA YNDYIRQPVQ LSQALQSWKN AYPNHAAATL FPKELLTLLN
260 270 280 290 300
FQQTNVSQIG LLLPLSGDGQ ILGTTIQSGF NDAKGNSTIP VQVFDTSMNS
310 320 330 340 350
VQDIIAQAKQ AGIKTLVGPL LKQNLDVILA DPAQIQGMDV LALNATPNSR
360 370 380 390 400
AIPQLCYYGL SPEDEAESAA NKMWNDGVRN PLVAMPQNDL GQRVGNAFNV
410 420 430 440 450
RWQQLAGTDA NIRYYNLPAD VTYFVQENNS NTTALYAVAS PTELAEMKGY
460 470 480 490 500
LTNIVPNLAI YASSRASASA TNTNTDFIAQ MNGVQFSDIP FFKDTNSPQY
510 520 530 540 550
QKLAKSTGGE YQLMRLYAMG ADAWLLINQF NELRQVPGYR LSGLTGILSA
560 570
DTNCNVERDM TWYQYQDGAI VPVAN
Length:575
Mass (Da):63,437
Last modified:November 1, 1995 - v1
Checksum:i3FCF093B22C56326
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23299.1.
PIRiB64174.
RefSeqiNP_439797.1. NC_000907.1.
WP_005694381.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23299; AAC23299; HI_1655.
GeneIDi950219.
KEGGihin:HI1655.
PATRICi20192059. VBIHaeInf48452_1733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23299.1.
PIRiB64174.
RefSeqiNP_439797.1. NC_000907.1.
WP_005694381.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CKMX-ray1.35A256-573[»]
4P29X-ray1.95A/B33-253[»]
ProteinModelPortaliP45299.
SMRiP45299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23299; AAC23299; HI_1655.
GeneIDi950219.
KEGGihin:HI1655.
PATRICi20192059. VBIHaeInf48452_1733.

Phylogenomic databases

eggNOGiENOG4105E1C. Bacteria.
COG3107. LUCA.
KOiK07121.
OMAiFCETPWL.
PhylomeDBiP45299.

Miscellaneous databases

EvolutionaryTraceiP45299.

Family and domain databases

HAMAPiMF_01890. LpoA. 1 hit.
InterProiIPR007443. LpoA.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF04348. LppC. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLPOA_HAEIN
AccessioniPrimary (citable) accession number: P45299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.