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Protein

Penicillin-binding protein activator LpoA

Gene

lpoA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell shape, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein activator LpoA
Short name:
PBP activator LpoA
Gene namesi
Name:lpoA
Ordered Locus Names:HI_1655
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 575550Penicillin-binding protein activator LpoAPRO_0000169453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi26 – 261N-palmitoyl cysteineSequence analysis
Lipidationi26 – 261S-diacylglycerol cysteineSequence analysis
Disulfide bondi356 ↔ 5541 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts with PBP1a.By similarity

Protein-protein interaction databases

STRINGi71421.HI1655.

Structurei

Secondary structure

1
575
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi34 – 396Combined sources
Helixi46 – 516Combined sources
Helixi53 – 553Combined sources
Helixi59 – 7517Combined sources
Helixi79 – 879Combined sources
Helixi94 – 11017Combined sources
Helixi114 – 1229Combined sources
Helixi126 – 1283Combined sources
Helixi131 – 14717Combined sources
Helixi151 – 16414Combined sources
Helixi168 – 18417Combined sources
Helixi187 – 1926Combined sources
Helixi199 – 21416Combined sources
Helixi218 – 23114Combined sources
Helixi236 – 2394Combined sources
Helixi243 – 2475Combined sources
Beta strandi259 – 2635Combined sources
Helixi270 – 28415Combined sources
Beta strandi291 – 2955Combined sources
Turni296 – 2983Combined sources
Helixi301 – 31010Combined sources
Beta strandi315 – 3173Combined sources
Helixi322 – 3309Combined sources
Helixi332 – 3354Combined sources
Beta strandi339 – 3435Combined sources
Beta strandi355 – 3573Combined sources
Helixi362 – 37514Combined sources
Beta strandi382 – 3887Combined sources
Helixi389 – 40618Combined sources
Beta strandi411 – 4177Combined sources
Helixi420 – 4278Combined sources
Beta strandi434 – 4374Combined sources
Helixi441 – 45111Combined sources
Turni452 – 4543Combined sources
Beta strandi459 – 4624Combined sources
Helixi464 – 4663Combined sources
Helixi469 – 4724Combined sources
Helixi475 – 4806Combined sources
Turni481 – 4833Combined sources
Beta strandi485 – 4884Combined sources
Helixi490 – 4934Combined sources
Helixi498 – 5069Combined sources
Turni507 – 5093Combined sources
Helixi511 – 52818Combined sources
Helixi530 – 5356Combined sources
Beta strandi541 – 5433Combined sources
Beta strandi546 – 5505Combined sources
Beta strandi555 – 5595Combined sources
Beta strandi561 – 5666Combined sources
Beta strandi569 – 5724Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CKMX-ray1.35A256-573[»]
4P29X-ray1.95A/B33-253[»]
ProteinModelPortaliP45299.
SMRiP45299. Positions 257-573.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45299.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpoA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105E1C. Bacteria.
COG3107. LUCA.
KOiK07121.
OMAiFCETPWL.
OrthoDBiEOG66MQQ3.
PhylomeDBiP45299.

Family and domain databases

HAMAPiMF_01890. LpoA.
InterProiIPR007443. LpoA.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF04348. LppC. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILLQGERF KKRLMPILLS MALAGCSNLL GSNFTQTLQK DANASSEFYI
60 70 80 90 100
NKLGQTQELE DQQTYKLLAA RVLIRENKVE QSAALLRELG ELNDAQKLDR
110 120 130 140 150
ALIEARISAA KNANEVAQNQ LRALDLNKLS PSQKSRYYET LAIVAENRKD
160 170 180 190 200
MIEAVKARIE MDKNLTDVQR HQDNIDKTWA LLRSANTGVI NNASDEGNAA
210 220 230 240 250
LGGWLTLIKA YNDYIRQPVQ LSQALQSWKN AYPNHAAATL FPKELLTLLN
260 270 280 290 300
FQQTNVSQIG LLLPLSGDGQ ILGTTIQSGF NDAKGNSTIP VQVFDTSMNS
310 320 330 340 350
VQDIIAQAKQ AGIKTLVGPL LKQNLDVILA DPAQIQGMDV LALNATPNSR
360 370 380 390 400
AIPQLCYYGL SPEDEAESAA NKMWNDGVRN PLVAMPQNDL GQRVGNAFNV
410 420 430 440 450
RWQQLAGTDA NIRYYNLPAD VTYFVQENNS NTTALYAVAS PTELAEMKGY
460 470 480 490 500
LTNIVPNLAI YASSRASASA TNTNTDFIAQ MNGVQFSDIP FFKDTNSPQY
510 520 530 540 550
QKLAKSTGGE YQLMRLYAMG ADAWLLINQF NELRQVPGYR LSGLTGILSA
560 570
DTNCNVERDM TWYQYQDGAI VPVAN
Length:575
Mass (Da):63,437
Last modified:November 1, 1995 - v1
Checksum:i3FCF093B22C56326
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23299.1.
PIRiB64174.
RefSeqiNP_439797.1. NC_000907.1.
WP_005694381.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23299; AAC23299; HI_1655.
GeneIDi950219.
KEGGihin:HI1655.
PATRICi20192059. VBIHaeInf48452_1733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23299.1.
PIRiB64174.
RefSeqiNP_439797.1. NC_000907.1.
WP_005694381.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CKMX-ray1.35A256-573[»]
4P29X-ray1.95A/B33-253[»]
ProteinModelPortaliP45299.
SMRiP45299. Positions 257-573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23299; AAC23299; HI_1655.
GeneIDi950219.
KEGGihin:HI1655.
PATRICi20192059. VBIHaeInf48452_1733.

Phylogenomic databases

eggNOGiENOG4105E1C. Bacteria.
COG3107. LUCA.
KOiK07121.
OMAiFCETPWL.
OrthoDBiEOG66MQQ3.
PhylomeDBiP45299.

Miscellaneous databases

EvolutionaryTraceiP45299.

Family and domain databases

HAMAPiMF_01890. LpoA.
InterProiIPR007443. LpoA.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF04348. LppC. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Structure of YraM, a protein essential for growth of Haemophilus influenzae."
    Vijayalakshmi J., Akerley B.J., Saper M.A.
    Proteins 73:204-217(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 256-573, DISULFIDE BOND.

Entry informationi

Entry nameiLPOA_HAEIN
AccessioniPrimary (citable) accession number: P45299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 11, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.