P45294 (PDXT_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamine amidotransferase subunit PdxT
EC=2.6.-.-

Alternative name(s):
Glutamine amidotransferase glutaminase subunit PdxT

Gene names

Name:	pdxT
Ordered Locus Names:	HI_1648

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS By similarity. HAMAP-Rule MF_01615
Pathway	Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. HAMAP-Rule MF_01615
Subunit structure	Forms a complex with PdxS By similarity.
Sequence similarities	Belongs to the glutamine amidotransferase PdxT/SNO family.
Sequence caution	The sequence AAC23295.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Glutamine amidotransferase
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutamine catabolic process Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	transferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Glutamine amidotransferase subunit PdxT HAMAP-Rule MF_01615		PRO_0000135641
Sites
	Active site	82	1	Nucleophile By similarity
	Active site	172	1	By similarity
	Active site	174	1	By similarity
	Binding site	109	1	Glutamine Potential

Sequences

	Sequence		Length	Mass (Da)
	P45294 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: 52297D26C0EE5579	FASTA	192	21,070
	10 20 30 40 50 60 MKIGILALQG AFAEHARMLE KLGIESVELR NLKNFQQHYS DLSGLILPGG ESTAIGKLLR 70 80 90 100 110 120 ELYMLEPIKQ AISSGFPVFG TCAGLILLAK EITSQKESHF GTMDIVVERN AYGRQLGSFY 130 140 150 160 170 180 TEADCKGVGK IPMTFIRGPI ISSVGKKVNI LATVNNKIVA AQEKNMLVTS FHPELTNNLS 190 LHKYFIDICK VA

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC23295.1. Different initiation.
PIR	G64173.
RefSeq	NP_439790.2. NC_000907.1.
3D structure databases
ProteinModelPortal	P45294.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI1648.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC23295; AAC23295; HI_1648.
GeneID	950854.
KEGG	hin:HI1648.
PATRIC	20192041. VBIHaeInf48452_1724.
Phylogenomic databases
eggNOG	COG0311.
KO	K08681.
OMA	TCAGMVL.
ProtClustDB	PRK13525.
Enzyme and pathway databases
UniPathway	UPA00245.
Family and domain databases
HAMAP	MF_01615. PdxT.
InterPro	IPR002161. Glutamine_amidoTferase_suPdxT. IPR021196. PdxT/SNO_CS. [Graphical view]
Pfam	PF01174. SNO. 1 hit. [Graphical view]
PIRSF	PIRSF005639. Glut_amidoT_SNO. 1 hit.
TIGRFAMs	TIGR03800. PLP_synth_Pdx2. 1 hit.
PROSITE	PS01236. PDXT_SNO_1. 1 hit. PS51130. PDXT_SNO_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDXT_HAEIN

Accession

Primary (citable) accession number: P45294

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program