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Protein

Riboflavin synthase

Gene

ribE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.By similarity

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi: riboflavin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. Riboflavin synthase (ribE)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137Substrate 2 bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processRiboflavin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Short name:
RS
Gene namesi
Name:ribE
Synonyms:ribC
Ordered Locus Names:HI_1613
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681671 – 204Riboflavin synthaseAdd BLAST204

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1613.

Structurei

3D structure databases

ProteinModelPortaliP45273.
SMRiP45273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 97Lumazine-binding 1Add BLAST97
Repeati98 – 195Lumazine-binding 2Add BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 6Substrate 1 bindingBy similarity3
Regioni48 – 50Substrate 2 binding; shared with one trimeric partnerBy similarity3
Regioni62 – 67Substrate 2 binding; shared with one trimeric partnerBy similarity6
Regioni101 – 103Substrate 2 binding; shared with one trimeric partnerBy similarity3
Regioni146 – 148Substrate 1 bindingBy similarity3
Regioni160 – 165Substrate 1 bindingBy similarity6

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108R6K. Bacteria.
COG0307. LUCA.
KOiK00793.
OMAiHILSGHV.
PhylomeDBiP45273.

Family and domain databases

Gene3Di2.40.30.20. 2 hits.
InterProiView protein in InterPro
IPR023366. ATP_synth_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
PANTHERiPTHR21098. PTHR21098. 1 hit.
PfamiView protein in Pfam
PF00677. Lum_binding. 2 hits.
PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMiSSF63380. SSF63380. 2 hits.
TIGRFAMsiTIGR00187. ribE. 1 hit.
PROSITEiView protein in PROSITE
PS51177. LUMAZINE_BIND. 2 hits.

Sequencei

Sequence statusi: Complete.

P45273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTGIVQGTA PIHSIKEKAN FRTQVVKLLP EMRKDLEIGA SIANNGVCLT
60 70 80 90 100
VTEINGDLVS FDLMQETLKI TNLGTVKVGD YVNIERAMQM GTEIGGHLLS
110 120 130 140 150
GHIYCTAKIS DIIASENNRQ IWFELPSADV MKYILTKGFV AVDGISLTIG
160 170 180 190 200
EVRDTQFCVN LIPETLQRTL MGRRKVGDIV NIEIDPQTQA IVDTVENYLQ

SKNF
Length:204
Mass (Da):22,590
Last modified:November 1, 1995 - v1
Checksum:iB7C2172F88BC1DA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23257.1.
PIRiE64132.
RefSeqiNP_439755.1. NC_000907.1.
WP_005693624.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23257; AAC23257; HI_1613.
GeneIDi950465.
KEGGihin:HI1613.
PATRICi20191957. VBIHaeInf48452_1686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23257.1.
PIRiE64132.
RefSeqiNP_439755.1. NC_000907.1.
WP_005693624.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP45273.
SMRiP45273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23257; AAC23257; HI_1613.
GeneIDi950465.
KEGGihin:HI1613.
PATRICi20191957. VBIHaeInf48452_1686.

Phylogenomic databases

eggNOGiENOG4108R6K. Bacteria.
COG0307. LUCA.
KOiK00793.
OMAiHILSGHV.
PhylomeDBiP45273.

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405.

Family and domain databases

Gene3Di2.40.30.20. 2 hits.
InterProiView protein in InterPro
IPR023366. ATP_synth_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
PANTHERiPTHR21098. PTHR21098. 1 hit.
PfamiView protein in Pfam
PF00677. Lum_binding. 2 hits.
PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMiSSF63380. SSF63380. 2 hits.
TIGRFAMsiTIGR00187. ribE. 1 hit.
PROSITEiView protein in PROSITE
PS51177. LUMAZINE_BIND. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRISA_HAEIN
AccessioniPrimary (citable) accession number: P45273
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 15, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.