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Reviewed, UniProtKB/Swiss-Prot P45261 (ILVI_HAEIN)

Last modified June 16, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Acetolactate synthase large subunit
      Short name=AHAS
    EC=2.2.1.6
Alternative name(s):
    Acetohydroxy-acid synthase large subunit
      Short name=ALS
Gene names
Name: ilvI
Ordered Locus Names: HI1585
OrganismHaemophilus influenzae [Complete proteome] [HAMAP]
Taxonomic identifier727 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

2 pyruvate = 2-acetolactate + CO2.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.

Subunit structure

Dimer of large and small chains By similarity.

Miscellaneous

Contains 1 molecule of FAD per monomer. The role of this cofactor is not clear considering that the reaction does not involve redox chemistry By similarity.

Sequence similarities

Belongs to the TPP enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573Acetolactate synthase large subunit
PRO_0000090795

Regions

Nucleotide binding261 – 28222FAD By similarity
Nucleotide binding304 – 32320FAD By similarity
Region396 – 47681Thiamine pyrophosphate binding

Sites

Metal binding4471Magnesium By similarity
Metal binding4741Magnesium By similarity
Binding site511Thiamine pyrophosphate By similarity
Binding site1531FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P45261-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: CA055388605F60BE

FASTA57362,620
        10         20         30         40         50         60 
MKKLSGAEMV VQSLRDEGVE YVFGYPGGAV LDIYDAIHTL GGIEHILVRH EQAAVHMADG 

        70         80         90        100        110        120 
YARSTGKVGC VLVTSGPGAT NAITGILTAY TDSVPMVIIS GQVMSNLIGS DAFQECDMLG 

       130        140        150        160        170        180 
ISRPVVKHSF IVKKAEDIPS TLKKAFYIAS TGRPGPVVVD IPKDTVNPNF KYPYEYPEYV 

       190        200        210        220        230        240 
ELRSYNPTVN GHKGQIKKAL KALLVAKKPI LFVGGGAITA ECSEQLIQFA QRLNLPVTSS 

       250        260        270        280        290        300 
LMGLGAYPST DKQFLGMLGM HGTLEANTAM HESDLILGIG VRFDDRTTNN LEKYCPNAKV 

       310        320        330        340        350        360 
IHIDIDPTSI SKNVPVAIPI VGNAKNVLEE FLGLLNEEGL KSQTDLESWW QEINQWKAKK 

       370        380        390        400        410        420 
CLEFDRTSGV IKPQQVVEAV YRLTKGQAYV ASDVGQHQMF AALHYPFDEP RHWINSGGAG 

       430        440        450        460        470        480 
TMGFGFPAAL GVKLAHPEGT VVCVTGDGSI QMNIQELSTA TQYGIPVVII CLNNHFLGMV 

       490        500        510        520        530        540 
KQWQDLIYSG RHSQTYMNSL PDFAKLAESY GHVGIKIATP DELESKLQEA FSIKNKLVFV 

       550        560        570 
DINVDESEHV YPMQIRGGAM NEMILSKPQE ETN 

« Hide

Cross-references

Sequence databases

L42023 Genomic DNA. Translation: AAC23233.1.
PIRC64131.
RefSeqNP_439730.1.

3D structure databases

HSSPHSSP built from PDB template 1N0H based on UniProtKB P07342.
ModBaseSearch...

Genome annotation databases

GeneID950449.
GenomeReviewsGene locus HI1585 in contig L42023_GR.
KEGGhin:HI1585.
NMPDRfig|71421.1.peg.1505.
TIGRHI1585.

Phylogenomic databases

HOGENOMP45261.
OMAP45261. QFRLPVK.

Enzyme and pathway databases

BioCycHINF71421:HI_1585-MON.
BRENDA2.2.1.6. 109.

Family and domain databases

InterProIPR012846. Acetolactate_synth_lsu.
IPR000399. TPP_bd_CS.
IPR012001. TPP_bd_enzyme_N.
IPR011766. TPP_enzyme_bd_C.
IPR012000. TPP_enzyme_M.
[Graphical view]
PfamPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00118. acolac_lg. 1 hit.
PROSITEPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVI_HAEIN
AccessionPrimary (citable) accession number: P45261
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents