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Protein

Acetolactate synthase small subunit

Gene

ilvH

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 pyruvate = 2-acetolactate + CO2.

Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase small subunit (ilvH), Acetolactate synthase large subunit (ilvI)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-valine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-valine from pyruvate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase small subunit (ilvH), Acetolactate synthase large subunit (ilvI)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1600-MONOMER
UniPathwayiUPA00047; UER00055
UPA00049; UER00059

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthase small subunit (EC:2.2.1.6)
Alternative name(s):
Acetohydroxy-acid synthase small subunit
Short name:
AHAS
Short name:
ALS
Gene namesi
Name:ilvH
Ordered Locus Names:HI_1584
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001514121 – 163Acetolactate synthase small subunitAdd BLAST163

Proteomic databases

PRIDEiP45260

Interactioni

Subunit structurei

Dimer of large and small chains.By similarity

Protein-protein interaction databases

STRINGi71421.HI1584

Structurei

3D structure databases

ProteinModelPortaliP45260
SMRiP45260
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 79ACTPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108ZP8 Bacteria
COG0440 LUCA
KOiK01653
OMAiRTGKIAM
PhylomeDBiP45260

Family and domain databases

Gene3Di3.30.70.1150, 1 hit
InterProiView protein in InterPro
IPR004789 Acetalactate_synth_ssu
IPR027271 Acetolactate_synth/TF_NikR_C
IPR019455 Acetolactate_synth_ssu_C
IPR002912 ACT_dom
PANTHERiPTHR30239 PTHR30239, 1 hit
PfamiView protein in Pfam
PF10369 ALS_ss_C, 1 hit
TIGRFAMsiTIGR00119 acolac_sm, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit

Sequencei

Sequence statusi: Complete.

P45260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRILSVLLE NESGALSRVV GLFSQRAFNI ESLTVAPTDD PTLSRMTIEA
60 70 80 90 100
VGDAQALEQI EKQLHKLVDV FKVVNLSEQE HIEREIVLAK VRAVGSSRDE
110 120 130 140 150
IKRLADIFRG QIVDVTPKSY TIQLSGTNDK VDAFISALKE ETTLLEIVRS
160
GLISVSRGEK NIL
Length:163
Mass (Da):18,087
Last modified:November 1, 1995 - v1
Checksum:i4F6AFBE71FDD8A32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC23232.1
PIRiB64131
RefSeqiNP_439729.1, NC_000907.1
WP_005647229.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC23232; AAC23232; HI_1584
GeneIDi950447
KEGGihin:HI1584
PATRICifig|71421.8.peg.1658

Similar proteinsi

Entry informationi

Entry nameiILVH_HAEIN
AccessioniPrimary (citable) accession number: P45260
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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