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Protein

2-dehydro-3-deoxyphosphooctonate aldolase

Gene

kdsA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate.

Pathwayi: 3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-dehydro-3-deoxyphosphooctonate aldolase (kdsA)
  3. no protein annotated in this organism
This subpathway is part of the pathway 3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate, the pathway 3-deoxy-D-manno-octulosonate biosynthesis and in Carbohydrate biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BRENDAi2.5.1.55. 2529.
UniPathwayiUPA00030.
UPA00357; UER00474.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolase (EC:2.5.1.55)
Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name:
KDO 8-P synthase
Short name:
KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase
Gene namesi
Name:kdsA
Ordered Locus Names:HI_1557
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001871311 – 2842-dehydro-3-deoxyphosphooctonate aldolaseAdd BLAST284

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1557.

Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 8Combined sources3
Beta strandi11 – 13Combined sources3
Beta strandi20 – 27Combined sources8
Helixi31 – 48Combined sources18
Beta strandi52 – 58Combined sources7
Helixi74 – 88Combined sources15
Beta strandi91 – 95Combined sources5
Helixi99 – 101Combined sources3
Helixi102 – 106Combined sources5
Beta strandi110 – 114Combined sources5
Helixi116 – 118Combined sources3
Helixi122 – 130Combined sources9
Beta strandi134 – 138Combined sources5
Helixi145 – 147Combined sources3
Helixi148 – 157Combined sources10
Beta strandi163 – 167Combined sources5
Helixi183 – 190Combined sources8
Beta strandi196 – 199Combined sources4
Helixi200 – 203Combined sources4
Helixi221 – 231Combined sources11
Beta strandi234 – 243Combined sources10
Helixi244 – 246Combined sources3
Helixi257 – 259Combined sources3
Helixi260 – 276Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O60X-ray1.80A/B/C/D1-284[»]
ProteinModelPortaliP45251.
SMRiP45251.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45251.

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsA family.Curated

Phylogenomic databases

eggNOGiENOG4105CXR. Bacteria.
COG2877. LUCA.
KOiK01627.
OMAiFRGIPTM.
PhylomeDBiP45251.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00056. KDO8P_synth. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01362. KDO8P_synth. 1 hit.

Sequencei

Sequence statusi: Complete.

P45251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNKIVKIGN IDVANDKPFV LFGGMNVLES RDMAMQVCEA YVKVTEKLGV
60 70 80 90 100
PYVFKASFDK ANRSSIHSYR GPGMEEGLKI FQELKDTFGV KIITDVHEIY
110 120 130 140 150
QCQPVADVVD IIQLPAFLAR QTDLVEAMAK TGAVINVKKP QFLSPSQMGN
160 170 180 190 200
IVEKIEECGN DKIILCDRGT NFGYDNLIVD MLGFSVMKKA SKGSPVIFDV
210 220 230 240 250
THSLQCRDPF GAASSGRRAQ VTELARSGLA VGIAGLFLEA HPNPNQAKCD
260 270 280
GPSALPLSAL EGFVSQMKAI DDLVKSFPEL DTSI
Length:284
Mass (Da):30,921
Last modified:November 1, 1995 - v1
Checksum:i7A3D2076A9B011B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23206.1.
PIRiG64129.
RefSeqiNP_439706.1. NC_000907.1.
WP_005693586.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23206; AAC23206; HI_1557.
GeneIDi950417.
KEGGihin:HI1557.
PATRICi20191839. VBIHaeInf48452_1628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23206.1.
PIRiG64129.
RefSeqiNP_439706.1. NC_000907.1.
WP_005693586.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O60X-ray1.80A/B/C/D1-284[»]
ProteinModelPortaliP45251.
SMRiP45251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1557.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23206; AAC23206; HI_1557.
GeneIDi950417.
KEGGihin:HI1557.
PATRICi20191839. VBIHaeInf48452_1628.

Phylogenomic databases

eggNOGiENOG4105CXR. Bacteria.
COG2877. LUCA.
KOiK01627.
OMAiFRGIPTM.
PhylomeDBiP45251.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00357; UER00474.
BRENDAi2.5.1.55. 2529.

Miscellaneous databases

EvolutionaryTraceiP45251.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00056. KDO8P_synth. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01362. KDO8P_synth. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKDSA_HAEIN
AccessioniPrimary (citable) accession number: P45251
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.