Skip Header

Contribute Send feedback
Read comments (?) or add your own

P45248 (BIOD2_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent dethiobiotin synthetase BioD 2
EC=6.3.3.3
Alternative name(s):
DTB synthetase 2
Short name=DTBS 2
Dethiobiotin synthase 2
Gene names
Name:bioD2
Synonyms:bioD-B
Ordered Locus Names:HI_1550
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring By similarity. HAMAP MF_00336

Catalytic activity

ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336

Cofactor

Magnesium By similarity. HAMAP MF_00336

Pathway

Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. HAMAP MF_00336

Subcellular location

Cytoplasm By similarity HAMAP MF_00336.

Sequence similarities

Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
   Biological processBiotin biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processbiotin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

dethiobiotin synthase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191ATP-dependent dethiobiotin synthetase BioD 2 HAMAP MF_00336
PRO_0000187970

Regions

Nucleotide binding13 – 186ATP By similarity
Nucleotide binding115 – 1184ATP By similarity

Sites

Metal binding131Magnesium 1 By similarity
Metal binding171Magnesium 2 By similarity
Metal binding501Magnesium 2 By similarity
Metal binding1151Magnesium 2 By similarity
Binding site421Substrate By similarity
Binding site501ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P45248 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 7C899BEC3FE60406

FASTA19121,097
        10         20         30         40         50         60 
MGKVIFISGI DTDVGKTIAT GIYAKKLMEQ GCSVITQKMI QTGCKNIADD LLVHRKIQGI 

        70         80         90        100        110        120 
DLTEEDLQGK TCPYVFEYPC SPHLAAKRES RKIEAKIIEK STALLAEKYD YVLLEGAGGL 

       130        140        150        160        170        180 
MVPYCEEATT LDYIQLNNYP LILVTSGKLG SINHTLLSLE ACRTRGISVL SVMYNGYPEY 

       190 
DLLLVKKPNA I

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC23200.1.
PIRB64129.
RefSeqNP_439699.1. NC_000907.1.

3D structure databases

ProteinModelPortalP45248.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID950414.
GenomeReviewsGene locus HI_1550 in contig L42023_GR.
KEGGhin:HI1550.
NMPDRfig|71421.1.peg.1477.
PATRIC20191825. VBIHaeInf48452_1621.
TIGRHI_1550.

Phylogenomic databases

HOGENOMHBG650065.
OMAIDTGIGK.
ProtClustDBPRK00090.

Enzyme and pathway databases

BioCycHINF71421:HI_1550-MONOMER.

Family and domain databases

HAMAPMF_00336. BioD.
[Tree]
InterProIPR002586. CbiA_P_synth.
IPR004472. DTB_synth_BioD.
[Graphical view]
KOK01935.
PfamPF01656. CbiA. 1 hit.
[Graphical view]
PIRSFPIRSF006755. DTB_synth. 1 hit.
TIGRFAMsTIGR00347. BioD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBIOD2_HAEIN
AccessionPrimary (citable) accession number: P45248
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents