Reviewed, UniProtKB/Swiss-Prot P45248 (BIOD2_HAEIN)

Names and origin

Protein names

Recommended name:
    Probable dethiobiotin synthetase 2
      Short name=Dethiobiotin synthase 2
      Short name=DTB synthetase 2
      Short name=DTBS 2
    EC=6.3.3.3

Gene names

Name:	bioD-B
Ordered Locus Names:	HI1550

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336
Cofactor	Magnesium By similarity.
Pathway	Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. HAMAP MF_00336
Sequence similarities	Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dethiobiotin synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Probable dethiobiotin synthetase 2 HAMAP MF_00336		PRO_0000187970
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45248-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 7C899BEC3FE60406	FASTA	191	21,097
	10 20 30 40 50 60 MGKVIFISGI DTDVGKTIAT GIYAKKLMEQ GCSVITQKMI QTGCKNIADD LLVHRKIQGI 70 80 90 100 110 120 DLTEEDLQGK TCPYVFEYPC SPHLAAKRES RKIEAKIIEK STALLAEKYD YVLLEGAGGL 130 140 150 160 170 180 MVPYCEEATT LDYIQLNNYP LILVTSGKLG SINHTLLSLE ACRTRGISVL SVMYNGYPEY 190 DLLLVKKPNA I

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC23200.1.
PIR	B64129.
RefSeq	NP_439699.1.
3D structure databases
HSSP	HSSP built from PDB template 1BYI based on UniProtKB P13000.
ModBase	Search...
Genome annotation databases
GeneID	950414.
GenomeReviews	Gene locus HI1550 in contig L42023_GR.
KEGG	hin:HI1550.
NMPDR	fig|71421.1.peg.1477.
TIGR	HI1550.
Phylogenomic databases
HOGENOM	P45248.
OMA	IDTGIGK.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1550-MON.
BRENDA	6.3.3.3. 109.
Family and domain databases
HAMAP	MF_00336. [Tree]
InterPro	IPR004472. BioD_synth. [Graphical view]
PIRSF	PIRSF006755. DTB_synth. 1 hit.
TIGRFAMs	TIGR00347. bioD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BIOD2_HAEIN

Accession

Primary (citable) accession number: P45248

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)