ID   Y1542_HAEIN             Reviewed;         184 AA.
AC   P45244;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   RecName: Full=Putative NAD(P)H nitroreductase HI_1542;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=HI_1542;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC       Note=Binds 1 FMN per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nitroreductase family. {ECO:0000305}.
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DR   EMBL; L42023; AAC23192.1; -; Genomic_DNA.
DR   PIR; D64172; D64172.
DR   RefSeq; NP_439691.1; NC_000907.1.
DR   AlphaFoldDB; P45244; -.
DR   SMR; P45244; -.
DR   STRING; 71421.HI_1542; -.
DR   DNASU; 950405; -.
DR   EnsemblBacteria; AAC23192; AAC23192; HI_1542.
DR   KEGG; hin:HI_1542; -.
DR   PATRIC; fig|71421.8.peg.1613; -.
DR   eggNOG; COG0778; Bacteria.
DR   HOGENOM; CLU_070764_5_0_6; -.
DR   OrthoDB; 9804207at2; -.
DR   PhylomeDB; P45244; -.
DR   BioCyc; HINF71421:G1GJ1-1562-MONOMER; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02135; YdjA-like; 1.
DR   Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   InterPro; IPR026021; YdjA-like.
DR   PANTHER; PTHR43821; NAD(P)H NITROREDUCTASE YDJA-RELATED; 1.
DR   PANTHER; PTHR43821:SF1; NAD(P)H NITROREDUCTASE YDJA-RELATED; 1.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   PIRSF; PIRSF000232; YdjA; 1.
DR   SUPFAM; SSF55469; FMN-dependent nitroreductase-like; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NAD; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..184
FT                   /note="Putative NAD(P)H nitroreductase HI_1542"
FT                   /id="PRO_0000169004"
FT   BINDING         10..12
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         35
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250"
FT   BINDING         39
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250"
FT   BINDING         122..127
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255"
FT   BINDING         132..134
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   184 AA;  20400 MW;  F2EBDC99020C1025 CRC64;
     MDALTLLTTR KSNKKLTAPA PNAEQLERIF EAAMRAPDHG KLHPYHFIVM ENESLNKLET
     LLKAAVVEFD LGEEKLMKAE NLAHRAPMVI GVVAKIDPTI AKVPGWEQML SAGCATYGLQ
     LAAQAQGFDN VWISGKWVNG TALREAFGCR EQDRVIALVM IGTGMEKAER ECRVIDTKDF
     VTYL
//