ID   Y1459_HAEIN             Reviewed;         194 AA.
AC   P45215;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   27-MAR-2024, entry version 127.
DE   RecName: Full=Probable RNA polymerase sigma factor HI_1459;
GN   OrderedLocusNames=HI_1459;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. ECF subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC23107.1; -; Genomic_DNA.
DR   PIR; G64124; G64124.
DR   RefSeq; NP_439610.2; NC_000907.1.
DR   AlphaFoldDB; P45215; -.
DR   SMR; P45215; -.
DR   STRING; 71421.HI_1459; -.
DR   EnsemblBacteria; AAC23107; AAC23107; HI_1459.
DR   KEGG; hin:HI_1459; -.
DR   PATRIC; fig|71421.8.peg.1522; -.
DR   eggNOG; COG1595; Bacteria.
DR   HOGENOM; CLU_047691_2_0_6; -.
DR   OrthoDB; 9782108at2; -.
DR   PhylomeDB; P45215; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IBA:GO_Central.
DR   GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd06171; Sigma70_r4; 1.
DR   Gene3D; 1.10.1740.10; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR014289; RNA_pol_sigma-24-rel.
DR   InterPro; IPR039425; RNA_pol_sigma-70-like.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000838; RNA_pol_sigma70_ECF_CS.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR013249; RNA_pol_sigma70_r4_t2.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   NCBIfam; TIGR02943; Sig70_famx1; 1.
DR   NCBIfam; TIGR02937; sigma70-ECF; 1.
DR   PANTHER; PTHR43133; RNA POLYMERASE ECF-TYPE SIGMA FACTO; 1.
DR   PANTHER; PTHR43133:SF62; RNA POLYMERASE SIGMA FACTOR HI_1459-RELATED; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF08281; Sigma70_r4_2; 1.
DR   SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR   SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 1.
DR   PROSITE; PS01063; SIGMA70_ECF; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Sigma factor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..194
FT                   /note="Probable RNA polymerase sigma factor HI_1459"
FT                   /id="PRO_0000094020"
FT   DNA_BIND        161..180
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOTIF           45..58
FT                   /note="Polymerase core binding"
SQ   SEQUENCE   194 AA;  22843 MW;  9E55F57235B43CE1 CRC64;
     MSFISYISFK GIKMNVISDL ELQQIRTQML TFAQLQVNQA DLAEDLVQEA FLSAFKNLAN
     FKRQSAFKTW IFAILKNKII DYLRQKGRFV LESELEDENT NNSFFDEKGH WKPEYHPSEL
     QGEEETVYSD EFWLIFETCL NCLPAKQAKI FMMREFLELS SEEICQETHL TSSNLHTTLY
     RARLQLQNCL SKKL
//